Induction of indoleamine 2,3-dioxygenase: a mechanism of the antitumor activity of interferon gamma.

Quinolinic Acid: An Endogenous Metabolite That Produces Axon-Sparing Lesions in Rat Brain

1983 • 1,247 citations

Biochemistry of Interferons and Their Actions

1982 • 868 citations

Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan.

1984 • 847 citations

pppA2'p5'A2'p5'A: an inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells.

1978 • 787 citations

Interferon-induced enzymatic activities and their role in the antiviral state

1979 • 392 citations

Induction of tryptophan catabolism is the mechanism for gamma-interferon-mediated inhibition of intracellular Chlamydia psittaci replication in T24 cells

1986 • 389 citations

THE CONVERSION OF TRYPTOPHAN TO KYNURENINE IN LIVER

1950 • 383 citations

Antitumor effects of interferon

1978 • 346 citations

Induction of pulmonary indoleamine 2,3-dioxygenase by interferon.

1981 • 285 citations

Tryptophan Pyrrolase of Rabbit Intestine

1967 • 284 citations

Inhibition of interferon action by actinomycin

1964 • 256 citations

Regulation of cell proliferation and differentiation by interferons

1985 • 241 citations

Human indolylamine 2,3-dioxygenase. Its tissue distribution, and characterization of the placental enzyme

1985 • 237 citations

Purified human immune interferon has more potent anticellular activity than fibroblast or leukocyte interferon

1980 • 221 citations

Interferon action: two distinct pathways for inhibition of protein synthesis by double-stranded RNA.

1978 • 216 citations

Nature of inhibitor of cell-free protein synthesis formed in response to interferon and double-stranded RNA

1977 • 198 citations

Isolation of two interferon-induced translational inhibitors: a protein kinase and an oligo-isoadenylate synthetase.

1978 • 194 citations

Biology of the interferon system

1983 • 192 citations

Interferon enhances tryptophan metabolism by inducing pulmonary indoleamine 2,3-dioxygenase: its possible occurrence in cancer patients.

1986 • 191 citations

Isoleucine-mediated regulation of genome repliction in various mammalian cell lines.

1971 • 188 citations

L-Asparaginase and L-Asparagine Metabolism

1970 • 160 citations

The Enzymatic Conversion of Quinolinate to Nicotinic Acid Mononucleotide in Mammalian Liver

1964 • 138 citations

METHANOL POISONING: ROLE OF FORMATE METABOLISM IN THE MONKEY

1977 • 132 citations

The Purification and Properties of Liver Tryptophan Pyrrolase

1962 • 128 citations

Enzymic formation of d-kynurenine from d-tryptophan

1967 • 120 citations

Interferon action: induction of specific proteins in mouse and human cells by homologous interferons.

1979 • 118 citations

Regulation of indoleamine 2,3-dioxygenase activity in the small intestine and the epididymis of mice

1980 • 112 citations

Role of amino acid supply in regulating ribosome function.

1968 • 112 citations

Oxidative reactivity of the tryptophan metabolites 3-hydroxyanthranilate, cinnabarinate, quinolinate and picolinate

1987 • 100 citations

The actions of interferon and antiinflammatory agents on induction of indoleamine 2,3-dioxygenase in human peripheral blood monocytes

1987 • 97 citations

QUINOLINIC ACID METABOLISM

1949 • 92 citations

Indoleamine 2,3-dioxygenase: incorporation of 18O2-- and 18O2 into the reaction products.

1977 • 86 citations

Interferon-dependent induction of mRNA activity for (2′–5′)oligo-isoadenylate synthetase

1980 • 74 citations

Control of messenger RNA translation by minor species of leucyl-transfer RNA in extracts from interferon-treated L cells

1976 • 73 citations

How does interferon inhibit tumor growth?

1985 • 71 citations

Synthesis of (2'-5')(A)n from ATP. Characteristics of the reaction catalyzed by (2'-5')(A)n synthetase purified from mouse Ehrlich ascites tumor cells treated with interferon.

1980 • 64 citations

Effect of actinomycin D and puromycin dihydrochloride on action of interferon

1964 • 64 citations

Induction of unique mRNAs by human interferons.

1982 • 59 citations

Impairment of reovirus mRNA methylation in extracts of interferon-treated Ehrilich ascites tumor cells: further characteristics of the phenomenon

1977 • 58 citations

Inhibition of Interferon Action by Puromycin

1965 • 57 citations

Indoleamine 2,3-dioxygenase. A new, rapid, sensitive radiometric assay and its application to the study of the enzyme in rat tissues

1980 • 54 citations

Cofactor activity of dihydroflavin mononucleotide and tetrahydrobiopterin for murine epididymal indoleamine 2,3-dioxygenase

1986 • 40 citations

Utilization of dihydroflavin mononucleotide and superoxide anion for the decyclization of l-tryptophan by murine epididymal indoleamine 2,3-dioxygenase

1987 • 39 citations

Regulation of DNA synthesis by amino acid limitation.

1973 • 33 citations

Interferon and Interferon Inducers. Clinical Applications

1981 • 31 citations

Sensitivity of various human lymphoblastoid cells to the antiviral and anticellular activity of human leukocyte interferon

1977 • 29 citations

Effects of tryptophan deprivation on L1210 cells in culture.

1974 • 28 citations

Accumulation of newly synthesized mRNAs in response to human fibroblast (beta) interferon.

1981 • 27 citations

Increase in S-adenosylhomocysteine concentration in interferon-treated HeLa cells and inhibition of methylation of vesicular stomatitis virus mRNA.

1983 • 27 citations

Cytocidal effect of purified human fibroblast interferon on tumor cells in vitro.

1981 • 24 citations

Growth Inhibition of Human Lymphoblastoid Cells by Interferon Preparations, Obtained from Human Leukocytes

1974 • 18 citations

Antiproliferative Activity of Highly Purified Mouse Interferon: Brief Communication 2

1978 • 18 citations