Indoleamine 2,3-dioxygenase in cancer: targeting pathological immune tolerance with small-molecule inhibitors

The Hallmarks of Cancer

2000 • 27,569 citations

Inflammation and cancer

2002 • 14,174 citations

Cancer immunoediting: from immunosurveillance to tumor escape

2002 • 4,911 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity

2001 • 2,658 citations

Prevention of Allogeneic Fetal Rejection by Tryptophan Catabolism

1998 • 2,538 citations

Heme-Containing Oxygenases

1996 • 2,346 citations

Ido expression by dendritic cells: tolerance and tryptophan catabolism

2004 • 2,235 citations

Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

2003 • 2,177 citations

The B7–CD28 superfamily

2002 • 1,646 citations

Inhibition of T Cell Proliferation by Macrophage Tryptophan Catabolism

1999 • 1,560 citations

Modulation of tryptophan catabolism by regulatory T cells

2003 • 1,323 citations

Escape of Human Solid Tumors from T–Cell Recognition: Molecular Mechanisms and Functional Significance

1999 • 1,168 citations

Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg

1992 • 1,156 citations

CTLA-4–Ig regulates tryptophan catabolism in vivo

2002 • 1,150 citations

Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients

1999 • 1,131 citations

Tryptophan-derived Catabolites Are Responsible for Inhibition of T and Natural Killer Cell Proliferation Induced by Indoleamine 2,3-Dioxygenase

2002 • 1,060 citations

Potential Regulatory Function of Human Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase

2002 • 1,035 citations

Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy

2005 • 1,021 citations

Relationship between interferon‐γ, indoleamine 2,3‐dioxygenase, and tryptophan catabolism

1991 • 1,018 citations

T cell apoptosis by tryptophan catabolism

2002 • 960 citations

Inhibition of Allogeneic T Cell Proliferation by Indoleamine 2,3-Dioxygenase–expressing Dendritic Cells

2002 • 917 citations

Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan.

1984 • 847 citations

Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes

2004 • 834 citations

Tolerance, DCs and tryptophan: much ado about IDO

2003 • 752 citations

Indoleamine 2,3-Dioxygenase Production by Human Dendritic Cells Results in the Inhibition of T Cell Proliferation

2000 • 733 citations

Tryptophan and the immune response

2003 • 725 citations

Immunotherapy and chemotherapy — a practical partnership

2005 • 639 citations

Neopterin as a marker for activated cell-mediated immunity: Application in HIV infection

1988 • 573 citations

T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo.

1992 • 558 citations

Urinary and brain beta-carboline-3-carboxylates as potent inhibitors of brain benzodiazepine receptors.

1980 • 542 citations

Ex Vivo Staining of Metastatic Lymph Nodes by Class I Major Histocompatibility Complex Tetramers Reveals High Numbers of Antigen-experienced Tumor-specific Cytolytic T Lymphocytes

1998 • 534 citations

Cutting Edge: Induced Indoleamine 2,3 Dioxygenase Expression in Dendritic Cell Subsets Suppresses T Cell Clonal Expansion

2003 • 460 citations

Ligation of B7-1/B7-2 by Human CD4+ T Cells Triggers Indoleamine 2,3-Dioxygenase Activity in Dendritic Cells

2004 • 459 citations

Cyclophosphamide, doxorubicin, and paclitaxel enhance the antitumor immune response of granulocyte/macrophage-colony stimulating factor-secreting whole-cell vaccines in HER-2/neu tolerized mice.

2001 • 454 citations

Sinks, suppressors and antigen presenters: how lymphodepletion enhances T cell-mediated tumor immunotherapy

2004 • 439 citations

Simultaneous Measurement of Serum Tryptophan and Kynurenine by HPLC,

1997 • 410 citations

Synergy between chemotherapy and immunotherapy in the treatment of established murine solid tumors.

2003 • 401 citations

Tryptophan degradation in mice initiated by indoleamine 2,3-dioxygenase.

1986 • 372 citations

Spinning molecular immunology into successful immunotherapy

2002 • 364 citations

Indoleamine 2,3‐dioxygenase contributes to tumor cell evasion of T cell‐mediated rejection

2002 • 364 citations

Indoleamine 2,3-dioxygenase. Purification and some properties

1978 • 362 citations

Eradication of Established Tumors by CD8+ T Cell Adoptive Immunotherapy

2000 • 349 citations

Cells Expressing Indoleamine 2,3-Dioxygenase Inhibit T Cell Responses

2002 • 344 citations

SOME VIRUS ISOLATIONS FROM COMMON COLDS

1960 • 334 citations

4-1BB-mediated immunotherapy of rheumatoid arthritis

2004 • 324 citations

In Vitro and in Vivo Formation of Two New Metabolites of Melatonin

1974 • 323 citations

end5, end6, and end7: mutations that cause actin delocalization and block the internalization step of endocytosis in Saccharomyces cerevisiae.

1995 • 305 citations

CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86

2004 • 296 citations

Quantitative Drug Design

2010 • 294 citations

Specific subsets of murine dendritic cells acquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine 2,3 dioxygenase

2004 • 290 citations

1-methyl-dl-tryptophan, β-(3-benzofuranyl)-dl-alanine (the oxygen analog of tryptophan), and β-[3-benzo(b)thienyl]-dl-alanine (the sulfur analog of tryptophan) are competitive inhibitors for indoleamine 2,3-dioxygenase

1991 • 279 citations

IDO and tolerance to tumors

2003 • 262 citations

Physical organic chemistry : reaction rates, equilibria, and mechanisms

1940 • 260 citations

The comparative pathology of human and mouse mammary glands.

1999 • 243 citations

Induction of indoleamine 2,3-dioxygenase: a mechanism of the antitumor activity of interferon gamma.

1988 • 241 citations

Human indolylamine 2,3-dioxygenase. Its tissue distribution, and characterization of the placental enzyme

1985 • 237 citations

Overexpression of c-erbB-2/neu in breast cancer cells confers increased resistance to Taxol via mdr-1-independent mechanisms.

1996 • 222 citations

Murine Plasmacytoid Dendritic Cells Initiate the Immunosuppressive Pathway of Tryptophan Catabolism in Response to CD200 Receptor Engagement

2004 • 218 citations

Reversal of immunological tolerance by cyclophosphamide through inhibition of suppressor cell activity

1974 • 209 citations

Tryptophan Catabolism and Regulation of Adaptive Immunity

2003 • 198 citations

More Rapid Method for Simultaneous Measurement of Tryptophan and Kynurenine by HPLC

2002 • 194 citations

β-Carboline-3-carboxylic acid ethyl ester antagonizes diazepam activity

1980 • 193 citations

Interferon-lnduced Indoleamine 2,3-Dioxygenase Activity in Human Mononuclear Phagocytes

1989 • 187 citations

The Role of IFN-γ and TNF-α-Responsive Regulatory Elements in the Synergistic Induction of Indoleamine Dioxygenase

2005 • 186 citations

Mechanism for elimination of a tumor suppressor: Aberrant splicing of a brain-specific exon causes loss of function of Bin1 in melanoma

1999 • 181 citations

The metabolism of tryptophan. 2. The metabolism of tryptophan in patients suffering from cancer of the bladder

1956 • 177 citations

[26] Indoleamine 2,3-dioxygenase

1987 • 176 citations

Convergence of TNF and IFN signalling pathways through synergistic induction of IRF-1/ISGF-2 is mediated by a composite GAS/ B promoter element

1997 • 165 citations

Cooperative Role of Interferon Regulatory Factor 1 and p91 (STAT1) Response Elements in Interferon-γ-inducible Expression of Human Indoleamine 2,3-Dioxygenase Gene

1996 • 155 citations

Biologic-response-modifier-induced indoleamine 2,3-dioxygenase activity in human peripheral blood mononuclear cell cultures.

1987 • 151 citations

Localization of indoleamine 2,3-dioxygenase in human female reproductive organs and the placenta

2002 • 140 citations

Interferons and indoleamine 2,3-dioxygenase: Role in antimicrobial and antitumor effects

1989 • 139 citations

Increased endogenous interferon-gamma and neopterin correlate with increased degradation of tryptophan in human immunodeficiency virus type 1 infection

1991 • 139 citations

Indoleamine 2,3-dioxygenase: distribution and function in the developing human placenta

2004 • 134 citations

Indoleamine 2,3-dioxygenase (IDO) expression in invasive extravillous trophoblast supports role of the enzyme for materno-fetal tolerance

2004 • 134 citations

Studien über den intermediären Stoffwechsel des Tryptophans XVIII—XXIV.

1936 • 122 citations

.beta.-Carbolines as benzodiazepine receptor ligands. 1. Synthesis and benzodiazepine receptor interaction of esters of .beta.-carboline-3-carboxylic acid

1983 • 120 citations

Enzymic formation of d-kynurenine from d-tryptophan

1967 • 120 citations

Cyclophosphamide (Cy)-facilitated adoptive immunotherapy of a Cy-resistant tumour. Evidence that Cy permits the expression of adoptive T-cell mediated immunity by removing suppressor T cells rather than by reducing tumour burden.

1988 • 119 citations

Characterisation of L‐tryptophan transporters in human placenta: a comparison of brush border and basal membrane vesicles

2001 • 118 citations

Antioxidants Inhibit Indoleamine 2,3-Dioxygenase in IFN-γ-Activated Human Macrophages: Posttranslational Regulation by Pyrrolidine Dithiocarbamate

2001 • 115 citations

Indoleamine 2,3-dioxygenase. Equilibrium studies of the tryptophan binding to the ferric, ferrous, and CO-bound enzymes.

1980 • 113 citations

Regulation of indoleamine 2,3-dioxygenase activity in the small intestine and the epididymis of mice

1980 • 112 citations

New degradative routes of 5-hydroxytryptophan and serotonin by intestinal tryptophan 2,3-dioxygenase

1972 • 112 citations

Functional Plasticity of Dendritic Cell Subsets as Mediated by CD40 Versus B7 Activation

2003 • 108 citations

Selective activation-induced apoptosis of peripheral T cells imposed by macrophages. A potential mechanism of antigen-specific peripheral lymphocyte deletion.

1996 • 106 citations

The effects of a novel and selective inhibitor of tryptophan 2,3-dioxygenase on tryptophan and serotonin metabolism in the rat

1995 • 105 citations

Importance of the Two Interferon-stimulated Response Element (ISRE) Sequences in the Regulation of the Human Indoleamine 2,3-Dioxygenase Gene

1996 • 100 citations

The Heme Environment of Recombinant Human Indoleamine 2,3-Dioxygenase

2002 • 95 citations

THE role of indoleamine 2,3‐dioxygenase in the anti‐tumour activity of human interferon‐γ in vivo

1995 • 93 citations

Molecular mechanisms underlying IFN-_γ-mediated tumor growth inhibition induced during tumor growth inhibition induced during tumor immunotherapy with rIL-12

1996 • 92 citations

Loss of heterozygosity and tumor suppressor activity ofBin1 in prostate carcinoma

2000 • 91 citations

Constitutive Expression of Functional 4-1BB (CD137) Ligand on Carcinoma Cells

2000 • 90 citations

Interferon-Gamma-Dependent/Independent Expression of Indoleamine 2,3-Dioxygenase

1999 • 89 citations

Farnesyltransferase Inhibitors Induce DNA Damage via Reactive Oxygen Species in Human Cancer Cells

2005 • 87 citations

Losses of the tumor suppressor BIN1 in breast carcinoma are frequent and reflect deficits in programmed cell death capacity

2000 • 86 citations

Enzyme kinetic and spectroscopic studies of inhibitor and effector interactions with indoleamine 2,3-dioxygenase. 1. Norharman and 4-phenylimidazole binding to the enzyme as inhibitors and heme ligands

1989 • 83 citations

The CTLA-4 gene is expressed in placental fibroblasts

1999 • 80 citations

Tuning tumor-specific T-cell activation: a matter of costimulation?

2002 • 78 citations

The preferred route of kynurenine metabolism in the rat

1982 • 74 citations

Inhibition of indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase by β-carboline and indole derivatives

1984 • 73 citations

TRYPTOPHAN METABOLISM IN CARCINOMA OF THE BREAST

1967 • 73 citations

Asp274 and His346 Are Essential for Heme Binding and Catalytic Function of Human Indoleamine 2,3-Dioxygenase

2003 • 73 citations

Involvement of Two Regulatory Elements in Interferon-γ-Regulated Expression of Human Indoleamine 2,3-Dioxygenase Gene

1995 • 73 citations

IFN-gamma is the inducer of indoleamine 2,3-dioxygenase in allografted tumor cells undergoing rejection.

1990 • 72 citations

Dependence of the in vitro antiproliferative activity of recombinant human gamma-interferon on the concentration of tryptophan in culture media.

1988 • 71 citations

Analysis of Transcription Factors Regulating Induction of Indoleamine 2,3-Dioxygenase by IFN-gamma

2000 • 62 citations

Simultaneous determination of tryptophan and kynurenine in serum by HPLC with UV and fluorescence detection

2004 • 62 citations

Extensive studies of the heme coordination structure of indoleamine 2,3-dioxygenase and of tryptophan binding with magnetic and natural circular dichroism and electron paramagnetic resonance spectroscopy

1984 • 60 citations

Expression of a MYCN-interacting isoform of the tumor suppressor BIN1 is reduced in neuroblastomas with unfavorable biological features.

2003 • 58 citations

The role of <scp>l</scp>‐tryptophan transport in <scp>l</scp>‐tryptophan degradation by indoleamine 2,3‐dioxygenase in human placental explants

2001 • 56 citations

Specific induction of indoleamine 2,3-dioxygenase by bacterial lipopolysaccharide in the mouse lung

1981 • 54 citations

Cytotoxic response of ovarian cancer cell lines to IFN-γ is associated with sustained induction of IRF-1 and p21 mRNA

1999 • 53 citations

Enhancement of tumor radioresponse by docetaxel: Involvement of immune system

2001 • 53 citations

Enzyme kinetic and spectroscopic studies of inhibitor and effector interactions with indoleamine 2,3-dioxygenase. 2. Evidence for the existence of another binding site in the enzyme for indole derivative effectors

1989 • 52 citations

Gene structure of human indoleamine 2,3-dioxygenase

1992 • 51 citations

Abnormalities of Tryptophan Metabolism and Plasma Pyridoxal Phosphate in Hodgkin's Disease

1970 • 49 citations

Direct and indirect effects of interferon on in vivo murine tumor cell growth.

1985 • 49 citations

T-Cell Adoptive Therapy of Tumors: Mechanisms of Improved Therapeutic Performance

2001 • 48 citations

Biomimetic approach to potential benzodiazepine receptor agonists and antagonists

1984 • 48 citations

Escape mechanisms in tumor immunity: a year 2000 update.

2000 • 47 citations

Cytokine regulation of human monocyte differentiation in vitro: the tumor-cytotoxic phenotype induced by macrophage colony-stimulating factor is developmentally regulated by gamma-interferon.

1993 • 43 citations

COSTIMULATION BLOCKADE PROMOTES THE APOPTOTIC DEATH OF GRAFT-INFILTRATING T CELLS AND PROLONGS SURVIVAL OF HEPATIC ALLOGRAFTS FROM FLT3L-TREATED DONORS1

2001 • 42 citations

Antitumor activity of gamma-interferon in ascitic and solid tumor models of human ovarian cancer.

1991 • 39 citations

Tumor Expression of 4-1BB Ligand Sustains Tumor Lytic T Cells

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Immunomodulating Anticancer Alkylating Drugs: Targets and Mechanisms of Activity

2001 • 34 citations

The metabolism of tryptophan

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Immunohistochemical localization of indoleamine 2,3-dioxygenase in the argyrophilic cells of rabbit duodenum and thyroid gland.

1981 • 29 citations

Neopterin Production and Tryptophan Degradation in Acute Lyme Neuroborreliosis Versus Late Lyme Encephalopathy

1994 • 28 citations

Structural requirements of the competitive binding site of recombinant human indoleamine 2,3-dioxygenase

1996 • 27 citations

Localization of indoleamine 2,3-dioxygenase gene (INDO) to chromosome 8p12→p11 by fluorescent in situ hybridization

1993 • 26 citations

Studies on the Metabolism of Tryptophan in Patients with Benign Prostatic Hypertrophy or Cancer of the Prostate

1968 • 20 citations

2,5-dihydro-L-phenylalanine: A competitive inhibitor of indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase

1978 • 17 citations

ChemInform Abstract: Evaluation of Substituted β‐Carbolines as Noncompetitive Indolamine 2,3‐Dioxygenase Inhibitors.

1994 • 15 citations

Interferon gamma regulates a unique set of proteins in fresh human bladder transitional cell carcinomas

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Some aspects of tryptophan--nicotinic acid chain in Hodgkin's disease. Relative roles of tryptophan loading and vitamin supplementation on urinary excretion of metabolites.

1962 • 14 citations

DISORDERS OF TRYPTOPHAN METABOLISM IN LEUKAEMIA.

1964 • 11 citations

Comparative Studies of the Indoleamine Dioxygenase-like Myoglobin from the Abalone Sulculus diversicolor

1997 • 11 citations

ENZYMATIC FORMATION OF D-KYNURENINE

1963 • 10 citations

Studies on tryptophan metabolites in the blood and urine of patients with leukemia

1959 • 4 citations