Abnormal T-Cell Reactivity against Paternal Antigens in Spontaneous Abortion

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

Prevention of Allogeneic Fetal Rejection by Tryptophan Catabolism

1998 • 2,538 citations

Regulatory T cells mediate maternal tolerance to the fetus

2004 • 1,568 citations

Regulatory T cells in transplantation tolerance

2003 • 1,323 citations

Regulatory T cells in the control of immune pathology

2001 • 1,197 citations

Th 1-type immunity is incompatible with successful pregnancy

1997 • 1,008 citations

Synthesis of T helper 2-type cytokines at the maternal-fetal interface.

1993 • 911 citations

Some immunological and endocrinological problems raised by the evolution of viviparity in verte- brates

1953 • 838 citations

IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In Vivo

2001 • 799 citations

CD25+CD4+ Regulatory T Cells Prevent Graft Rejection: CTLA-4- and IL-10-Dependent Immunoregulation of Alloresponses

2002 • 766 citations

Normal human pregnancy is associated with an elevation in the immune suppressive CD25⁺ CD4⁺ regulatory T‐cell subset

2004 • 727 citations

Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases

2004 • 727 citations

Direct evidence to support the role of HLA-G in protecting the fetus from maternal uterine natural killer cytolysis

1997 • 691 citations

Defective production of both leukemia inhibitory factor and type 2 T-helper cytokines by decidual T cells in unexplained recurrent abortions

1998 • 670 citations

Cd4+Cd25+ Immune Regulatory Cells Are Required for Induction of Tolerance to Alloantigen via Costimulatory Blockade

2001 • 580 citations

T Cell Awareness of Paternal Alloantigens During Pregnancy

1995 • 568 citations

IL-10 prevents naturally occurring fetal loss in the CBA x DBA/2 mating combination, and local defect in IL-10 production in this abortion-prone combination is corrected by in vivo injection of IFN-τ

2005 • 463 citations

Cytokine network at the feto-maternal interface

2000 • 393 citations

T helper 1 response against Leishmania major in pregnant C57BL/6 mice increases implantation failure and fetal resorptions. Correlation with increased IFN-gamma and TNF and reduced IL-10 production by placental cells.

1996 • 345 citations

Maternal Th1- and Th2-Type Reactivity to Placental Antigens in Normal Human Pregnancy and Unexplained Recurrent Spontaneous Abortions

1999 • 331 citations

Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. III. Further characterization of the CD4+ suppressor cell and its mechanisms of action.

1990 • 302 citations

A brief review of recent data on some cytokine expressions at the materno-foetal interface which might challenge the classical Th1/Th2 dichotomy

2002 • 270 citations

Corticotropin-releasing hormone promotes blastocyst implantation and early maternal tolerance

2001 • 222 citations

Why Did Your Mother Reject You? Immunogenetic Determinants of the Response to Environmental Selective Pressure Expressed at the Uterine Level

1999 • 198 citations

Antigen Barrier of the Mouse Placenta

1964 • 186 citations

Regulatory T cells and organ transplantation

2004 • 177 citations

Th2 cells are less susceptible than Th1 cells to the suppressive activity of CD25+ regulatory thymocytes because of their responsiveness to different cytokines

2003 • 172 citations

Murine pregnancy decidua produces a unique immunosuppressive molecule related to transforming growth factor beta-2.

1990 • 157 citations

The Th2 Cytokine Environment of the Placenta

2000 • 153 citations

Early Pregnancy Loss: Mechanisms and Treatment

1989 • 149 citations

Impairment of host-versus-graft reaction in pregnant mice. II. Selective suppression of cytotoxic T-cell generation correlates with soluble suppressor activity and with successful allogeneic pregnancy.

1980 • 149 citations

Vaccination against spontaneous abortion in mice

1983 • 140 citations

The Murine Placenta as an Immunological Barrier Between the Mother and the Fetus

1983 • 139 citations

The Th2 cytokines IL-4 and IL-10 are not crucial for the completion of allogeneic pregnancy in mice

2001 • 134 citations

Impairment of host-versus-graft reaction in pregnant mice

1980 • 131 citations

The progesterone derivative dydrogesterone abrogates murine stress-triggered abortion by inducing a Th2 biased local immune response

2003 • 121 citations

The role of CD4⁺ T‐cell subsets in determining transplantation rejection or tolerance

2001 • 120 citations

Tgfß2 -/- Tgfß3 -/- double knockout mice display severe midline fusion defects and early embryonic lethality

2002 • 116 citations

Ovarian insufficiency and early pregnancy loss induced by activation of the innate immune system

2004 • 108 citations

Regulation of Progesterone Receptors and Decidualization in Uterine Stroma of the Estrogen Receptor-α Knockout Mouse1

2001 • 104 citations

Maternal anti-placental reactivity in natural, immunologically-mediated fetal resorptions.

1994 • 102 citations

Ovarian insufficiency and early pregnancy loss induced by activation of the innate immune system

2004 • 102 citations

Localization of the Th2 Cytokines IL‐3, IL‐4, IL‐10 at the Fetomaternal Interface During Human and Murine Pregnancy and Lack of Requirement for Fas/Fas Ligand Interaction for a Successful Allogeneic Pregnancy

1999 • 95 citations

IL-2 and IL-4 Double Knockout Mice Reject Islet Allografts: A Role for Novel T Cell Growth Factors in Allograft Rejection

1998 • 94 citations

Effect of Interleukin-10 Null Mutation on Maternal Immune Response and Reproductive Outcome in Mice1

2004 • 90 citations

Extinguishing maternal immune responses during pregnancy: implications for immunosuppression

2001 • 84 citations

The adoptive transfer of pregnancy-induced unresponsiveness to male skin grafts with thymus-dependent cells.

1977 • 82 citations

Murine abortion is associated with enhanced interleukin-6 levels at the feto-maternal interface

2003 • 82 citations

Questioning the Th1/Th2 Paradigm in Reproduction: Peripheral Levels of IL‐12 are Down‐Regulated in Miscarriage Patients

2002 • 81 citations

Murine Stress‐triggered Abortion is Mediated by Increase of CD8⁺ TNF‐α⁺ Decidual Cells via Substance P

2001 • 69 citations

2 The normal fetomaternal immune relationship

1992 • 61 citations

Regulatory Cells Potentiate the Efficacy of IL-4 Gene Transfer by Up-Regulating Th2-Dependent Expression of Protective Molecules in the Infectious Tolerance Pathway in Transplant Recipients

2000 • 56 citations

Upregulation of Decidual P-Selectin Expression Is Associated with an Increased Number of Th1 Cell Populations in Patients Suffering from Spontaneous Abortions

2001 • 55 citations

Thymic involution in pregnant mice. I. Characterization of the remaining thymocyte subpopulations.

1981 • 50 citations

TGF beta 2 mRNA expression and pregnancy failure in mice.

1999 • 47 citations

During Pregnancy, in the Context of a Th2‐Type Cytokine Profile, Serum IL‐6 Levels Might Condition the Quality of the Synthesized Antibodies

2001 • 42 citations

Histological changes in the thymus during mouse pregnancy.

1989 • 41 citations

Interleukin‐6 and Soluble Interleukin‐6 Receptor Serum Levels in Recurrent Spontaneous Abortion Women Immunized with Paternal White Cells

2000 • 38 citations

TGFβ2 mRNA Expression and Pregnancy Failure in Mice*

1999 • 34 citations

Thymic involution in pregnant mice. II. Functional aspects of the remaining thymocytes.

1981 • 29 citations

The effects of pregnancy on the mouse thymic epithelium

1994 • 17 citations

Pregnancy-Associated Effect on Mouse Thymocytes in Vitro

1995 • 12 citations

The “Infectious” Tolerance Pathway in Organ Allograft Recipients

1998 • 9 citations