Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes

1983 • 1,449 citations

A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene

1983 • 1,418 citations

Organization of the higher-order chromatin loop: specific DNA attachment sites on nuclear scaffold

1984 • 1,088 citations

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

1993 • 984 citations

Chromosomal loop anchorage of the kappa immunoglobulin gene occurs next to the enhancer in a region containing topoisomerase II sites

1986 • 922 citations

Repeat-induced gene silencing in mammals

1998 • 884 citations

Developmentally controlled and tissue-specific expression of unrearranged VH gene segments

1985 • 710 citations

Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines

1984 • 644 citations

Cell-type specificity of iminunoglobulin gene expression is regulated by at least three DNA sequence elements

1985 • 588 citations

A tissue-specific MAR/SAR DNA-binding protein with unusual binding site recognition

1992 • 508 citations

Production of homozygous mutant ES cells with a single targeting construct.

1992 • 418 citations

Biological Significance of Unwinding Capability of Nuclear Matrix-Associating DNAs

1992 • 407 citations

RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development.

1993 • 393 citations

Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus.

1995 • 351 citations

Scaffold-associated regions: cis-acting determinants of chromatin structural loops and functional domains

1992 • 319 citations

Introduction of a μ immunoglobulin gene into the mouse germ line: Specific expression in lymphoid cells and synthesis of functional antibody

1984 • 304 citations

Immunoglobulin Gene Transcription

1991 • 294 citations

SAR-dependent mobilization of histone H1 by HMG-I/Y in vitro: HMG-I/Y is enriched in H1-depleted chromatin.

1993 • 288 citations

A class switch control region at the 3′ end of the immunoglobulin heavy chain locus

1994 • 267 citations

Extension of chromatin accessibility by nuclear matrix attachment regions

1997 • 237 citations

The enhancer of the immunoglobulin heavy chain locus is flanked by presumptive chromosomal loop anchorage elements.

1987 • 229 citations

Each hypersensitive site of the human beta-globin locus control region confers a different developmental pattern of expression on the globin genes.

1993 • 226 citations

Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate.

1990 • 224 citations

V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer.

1993 • 219 citations

Dependence of Enhancer-Mediated Transcription of the Immunoglobulin μ Gene on Nuclear Matrix Attachment Regions

1994 • 216 citations

Chromatin Domains and Prediction of MAR Sequences

1996 • 193 citations

Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus.

1993 • 190 citations

Matrix attachment regions are positioned near replication initiation sites, genes, and an interamplicon junction in the amplified dihydrofolate reductase domain of Chinese hamster ovary cells.

1988 • 177 citations

Immunoglobulin heavy-chain expression and class switching in a murine leukaemia cell line

1982 • 173 citations

The Igκ 3′ Enhancer Influences the Ratio of Igκ versus Igλ B Lymphocytes

1996 • 166 citations

Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility.

1996 • 164 citations

The Architectural Organization of Nuclear Metabolism

1996 • 150 citations

Class Switching in B Cells Lacking 3′ Immunoglobulin Heavy Chain Enhancers

1998 • 144 citations

Production of Homozygous Mutant ES Cells with a Single Targeting Construct

1992 • 140 citations

The immunoglobulin heavy-chain B-lymphocyte enhancer efficiently stimulates transcription in non-lymphoid cells.

1986 • 140 citations

Scaffold/Matrix-Attached Regions: Topological Switches with Multiple Regulatory Functions

1996 • 131 citations

Deletion of the IgH enhancer does not reduce immunoglobulin heavy chain production of a hybridoma IgD class switch variant.

1984 • 127 citations

Functional analysis of the murine IgH enhancer: evidence for negative control of cell-type specificity

1986 • 123 citations

The Matrix Attachment Region-Binding Protein SATB1 Participates in Negative Regulation of Tissue-Specific Gene Expression

1997 • 117 citations

Combinatorial regulation of transcription II: the immunoglobulin μ heavy chain gene

1995 • 116 citations

Synergism between immunoglobulin enhancers and promoters

1986 • 116 citations

A developmental-specific factor binds to suppressor sites flanking the immunoglobulin heavy-chain enhancer.

1989 • 116 citations

The immunoglobulin mu enhancer core establishes local factor access in nuclear chromatin independent of transcriptional stimulation.

1993 • 112 citations

Immunoglobulin heavy-chain class switching in a pre-B cell line is accompanied by DNA rearrangement

1983 • 105 citations

Deletion of a B-cell-specific enhancer affects transfected, but not endogenous, immunoglobulin heavy-chain gene expression.

1985 • 92 citations

Position-dependent inhibition of class-switch recombination by PGK-neo^rcassettes inserted into the immunoglobulin heavy chain constant region locus

1999 • 91 citations

Differential activation of transcription versus recombination of transgenic T cell receptor beta variable region gene segments in B and T lineage cells.

1994 • 85 citations

Independent immunoglobulin class-switch events occurring in a single myeloma cell line.

1985 • 81 citations

A V(D)J recombinase-inducible B-cell line: role of transcriptional enhancer elements in directing V(D)J recombination.

1993 • 81 citations

A Thymocyte Factor SATB1 Suppresses Transcription of Stably Integrated Matrix-Attachment Region-Linked Reporter Genes

1997 • 80 citations

Immunoglobulin gene transcription ceases upon deletion of a distant enhancer.

1995 • 79 citations

Nuclear matriax attachment occurs in several regions of the IgH locus

1990 • 73 citations

Characterization of immunoglobulin enhancer deletions in murine plasmacytomas.

1985 • 72 citations

Efficacious Production of Viable Germ-Line Chimeras between Embryonic Stem (ES) Cells and 8-Cell Stage Embryos. (embryonic stem cell/mouse embryo chimera/germ line transmission)

1992 • 70 citations

Biochemical and functional analyses of chromatin changes at the TCR-beta gene locus during CD4-CD8- to CD4+CD8+ thymocyte differentiation.

1998 • 69 citations

Deletion of the IgH intronic enhancer and associated matrix-attachment regions decreases, but does not abolish, class switching at the mu locus

1998 • 66 citations

Immunoglobulin heavy chain enhancer is located near or in an initiation zone of chromosomal DNA replication.

1993 • 63 citations

A Nuclear Matrix Attachment Region Upstream of the T Cell Receptor β Gene Enhancer Binds Cux/CDP and SATB1 and Modulates Enhancer-dependent Reporter Gene Expression but Not Endogenous Gene Expression

1998 • 61 citations

The 3′ enhancer region determines the B/T specificity and pro-B/pre-B specificity of immunoglobulin Vκ-Jκ joining

1995 • 59 citations

Identification of a matrix-associated region 5' of an immunoglobulin heavy chain variable region gene.

1991 • 58 citations

Biochemical and Functional Analyses of Chromatin Changes at the TCR-β Gene Locus During CD4−CD8− to CD4+CD8+ Thymocyte Differentiation

1998 • 57 citations

Developmentally controlled and tissue-specific expression of unrearranged VH gene segments. Cell. 1985. 40: 271-281.

2012 • 55 citations

Matrix Attachment Regions Are Positioned Near Replication Initiation Sites, Genes, and an Interamplicon Junction in the Amplified Dihydrofolate Reductase Domain of Chinese Hamster Ovary Cells

1988 • 52 citations

Regulation of Immunoglobulin Gene Transcription

1992 • 50 citations

Reevaluation of 3′Eκ Function in Stage- and Lineage-Specific Rearrangement and Somatic Hypermutation

1998 • 49 citations

Contributions of Nuclear Architecture to Transcriptional Control

1996 • 44 citations

Independent Immunoglobulin Class-Switch Events Occurring in a Single Myeloma Cell Line

1985 • 32 citations

A V(D)J Recombinase-Inducible B-Cell Line: Role of Transcriptional Enhancer Elements in Directing V(D)J Recombination

1993 • 29 citations

Murine and Human 3′ IgH Regulatory Sequences

1997 • 29 citations

Identification of a Matrix-Associated Region 5′ of an Immunoglobulin Heavy Chain Variable Region Gene

1991 • 21 citations

A DNA-binding Element for a Steroid Receptor-binding Factor Is Flanked by Dual Nuclear Matrix DNA Attachment Sites in the c-myc Gene Promoter

1997 • 14 citations