Efficacious Production of Viable Germ-Line Chimeras between Embryonic Stem (ES) Cells and 8-Cell Stage Embryos. (embryonic stem cell/mouse embryo chimera/germ line transmission)

Establishment in culture of pluripotential cells from mouse embryos

1981 • 8,424 citations

Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.

1981 • 5,629 citations

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1991 • 2,028 citations

The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium

1985 • 1,983 citations

A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting

1990 • 1,650 citations

The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

1990 • 1,531 citations

Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines

1984 • 1,518 citations

HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells

1987 • 1,231 citations

Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development

1990 • 896 citations

Culture of mouse ova.

1971 • 810 citations

Embryonic stem cells alone are able to support fetal development in the mouse

1990 • 789 citations

Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector

1986 • 761 citations

Immunosurgery of mouse blastocyst.

1975 • 669 citations

An assessment of the developmental potential of embryonic stem cells in the midgestation mouse embryo

1989 • 596 citations

Activation of mammalian oocytes by intracellular injection of calcium

1978 • 582 citations

A potential animal model for Lesch–Nyhan syndrome through introduction of HPRT mutations into mice

1987 • 487 citations

Transgenesis by means of blastocyst-derived embryonic stem cell lines.

1986 • 432 citations

Germ-line transmission of a disrupted β2microglobulin gene produced by homologous recombination in embryonic stem cells

1989 • 355 citations

Germ-Line Transmission of a c- abl Mutation Produced by Targeted Gene Disruption in ES Cells

1989 • 285 citations

Production of a mutation in mouse En-2 gene by homologous recombination in embryonic stem cells

1989 • 200 citations

Establishment of pluripotential cell lines from haploid mouse embryos

1983 • 178 citations

Production of chimaeric mice containing embryonic stem (ES) cells carrying a homoeobox Hox 1.1 allele mutated by homologous recombination

1989 • 166 citations

Cell division and cell allocation in early mouse development

1978 • 155 citations

Androgenetic mouse embryonic stem cells are pluripotent and cause skeletal defects in chimeras: Implications for genetic imprinting

1990 • 147 citations

3. Teratocarcinomas and Embryonic Stem Cells

2016 • 141 citations

Effect of cutting the zona pellucida on the pronuclear transplantation in the mouse

1986 • 115 citations

Ability of outside cells from preimplantation mouse embryos to form inner cell mass derivatives

1980 • 114 citations

Spatial distribution of blastomeres is dependent on cell division order and interactions in mouse morulae

1984 • 95 citations

Cell allocation in preimplantation mouse chimeras

1982 • 76 citations

Pluripotent embryonic stem cell lines can be derived from tw5/tw5 blastocysts

1982 • 71 citations

An in situ assessment of the routes and extents of colonisation of the mouse embryo by embryonic stem cells and their descendants

1990 • 57 citations

Establishment of embryonic stem cell lines from preimplantation mouse embryos homozygous for lethal mutations in the t-complex

1987 • 30 citations

Internalization of Embryonal Carcinoma Cells when Aggregated with Normal Mouse Embryos

1987 • 9 citations