Production of Homozygous Mutant ES Cells with a Single Targeting Construct

Current protocols in molecular biology

1988 • 4,543 citations

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

1987 • 2,368 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

Targetted correction of a mutant HPRT gene in mouse embryonic stem cells

1987 • 786 citations

Germ-line transmission of a disrupted β2microglobulin gene produced by homologous recombination in embryonic stem cells

1989 • 355 citations

Double targeted gene replacement for creating null mutants.

1991 • 323 citations

Germ-Line Transmission of a c- abl Mutation Produced by Targeted Gene Disruption in ES Cells

1989 • 285 citations

Consecutive inactivation of both alleles of the pim-1 proto-oncogene by homologous recombination in embryonic stem cells

1990 • 248 citations

Unusual organization and diversity of T-cell receptor a-chain genes

1985 • 212 citations

Production of a mutation in mouse En-2 gene by homologous recombination in embryonic stem cells

1989 • 200 citations

Production of chimaeric mice containing embryonic stem (ES) cells carrying a homoeobox Hox 1.1 allele mutated by homologous recombination

1989 • 166 citations

Molecular evidence that homologous recombination occurs in proliferating human somatic cells.

1990 • 93 citations

Embryonic stem cells lacking a functional inhibitory G-protein subunit (alpha i2) produced by gene targeting of both alleles.

1991 • 90 citations

Genetic demonstration of mitotic recombination in cultured chinese hamster cell hybrids

1984 • 69 citations

Graduated resistance to G418 leads to differential selection of cultured mammalian cells expressing the neo gene

1989 • 29 citations

Mitotic recombination between homologous chromosomes generates H-2 somatic cell variants in vitro.

1987 • 25 citations

Segregation of Recessive Phenotypes in Somatic Cell Hybrids: Role of Mitotic Recombination, Gene Inactivation, and Chromosome Nondisjunction

1981 • 18 citations

Mitotic Recombination Is Responsible for the Loss of Heterozygosity in Cultured Murine Cell Lines

1989 • 13 citations

Rate and mechanism of generation of beta 2-microglobulin mutants from a heterozygous murine cell line.

1990 • 5 citations