Each hypersensitive site of the human beta-globin locus control region confers a different developmental pattern of expression on the globin genes.

Position-independent, high-level expression of the human β-globin gene in transgenic mice

1987 • 1,955 citations

The "beta-like-globin" gene domain in human erythroid cells.

1985 • 634 citations

Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids

1987 • 440 citations

Erythroid-specific expression of human beta-globin genes in transgenic mice.

1985 • 436 citations

Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice

1990 • 364 citations

A dominant control region from the human β-globin locus conferring integration site-independent gene expression

1989 • 346 citations

Definition of the minimal requirements within the human beta-globin gene and the dominant control region for high level expression.

1990 • 322 citations

Detailed analysis of the site 3 region of the human beta-globin dominant control region.

1990 • 320 citations

The β-globin dominant control region activates homologous and heterologous promoters in a tissue-specific manner

1989 • 302 citations

The beta-globin dominant control region: hypersensitive site 2.

1990 • 295 citations

Importance of globin gene order for correct developmental expression.

1991 • 294 citations

Human gamma- to beta-globin gene switching in transgenic mice.

1990 • 291 citations

Regulated expression of human Aγ-, β-, and hybrid γβ-globin genes in transgenic mice: Manipulation of the developmental expression patterns

1986 • 275 citations

Developmental regulation of a complete 70-kb human beta-globin locus in transgenic mice.

1992 • 218 citations

Developmental regulation of a cloned adult β-globin gene in transgenic mice

1985 • 215 citations

Assembly of snRNP-containing coiled bodies is regulated in interphase and mitosis--evidence that the coiled body is a kinetic nuclear structure.

1993 • 214 citations

An embryonic pattern of expression of a human fetal globin gene in transgenic mice

1986 • 204 citations

Human γ-globin genes silenced independently of other genes in the β-globin locus

1991 • 191 citations

DNasel hypersensitive sites 1, 2 and 3 of the human β-globin dominant control region direct position-independent expression

1990 • 186 citations

Autonomous Developmental Control of Human Embryonic Globin Gene Switching in Transgenic Mice

1990 • 151 citations

A single point mutation is the cause of the Greek form of hereditary persistence of fetal haemoglobin

1992 • 147 citations

Hypersensitive site 4 of the human β globin locus control region

1991 • 141 citations

Synthetic human beta-globin 5′HS2 constructs function as locus control regions only in multicopy transgene concatamers.

1993 • 126 citations

An in vitro globin gene switching model based on differentiated embryonic stem cells.

1990 • 125 citations

The minimal requirements for activity in transgenic mice of hypersensitive site 3 of the beta globin locus control region.

1993 • 103 citations

In vivo protein-DNA interactions at hypersensitive site 3 of the human beta-globin locus control region.

1992 • 99 citations

γδβ-Thalassaemias 1 and 2 are the result of a 100 kbp deletion in the human β-globin cluster

1986 • 95 citations

Developmentally regulated and erythroid-specific expression of the human embryonic β-globin gene in transgenic mice

1990 • 68 citations