Position-dependent inhibition of class-switch recombination by PGK-neo^rcassettes inserted into the immunoglobulin heavy chain constant region locus

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

1993 • 984 citations

A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development

1997 • 683 citations

Handbook of experimental immunology

1986 • 637 citations

Mechanism and Regulation of Immunoglobulin Isotype Switching

1993 • 516 citations

Immunoglobulin class switching

1996 • 446 citations

Active anaphylaxis in IgE-deficient mice

1994 • 414 citations

Long-range disruption of gene expression by a selectable marker cassette

1996 • 377 citations

Towards a comprehensive view of immunoglobulin class switching

1993 • 373 citations

Hoxb-4 (Hox-2.6) mutant mice show homeotic transformation of a cervical vertebra and defects in the closure of the sternal rudiments

1993 • 352 citations

Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus.

1995 • 351 citations

Shutdown of Class Switch Recombination by Deletion of a Switch Region Control Element

1993 • 340 citations

Enhanced B-1 Cell Development, But Impaired IgG Antibody Responses in Mice Deficient in Secreted IgM

1998 • 321 citations

A class switch control region at the 3′ end of the immunoglobulin heavy chain locus

1994 • 267 citations

Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt's lymphoma cells.

1994 • 258 citations

Switch Transcripts in Immunoglobulin Class Switching

1995 • 248 citations

A strain-specific modifier on mouse chromosome 4 controls the methylation of independent transgene loci

1991 • 223 citations

A second B cell-specific enhancer 3' of the immunoglobulin heavy-chain locus

1990 • 220 citations

S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process.

1994 • 214 citations

A selective defect in IgG2b switching as a result of targeted mutation of the I gamma 2b promoter and exon.

1993 • 206 citations

Function of the TCRα Enhancer in αβ and γδ T Cells

1997 • 204 citations

The Effect of Distance on Long-Range Chromatin Interactions

1997 • 196 citations

The β-Globin LCR Is Not Necessary for an Open Chromatin Structure or Developmentally Regulated Transcription of the Native Mouse β-Globin Locus

1998 • 185 citations

Analysis of Mice Containing a Targeted Deletion of β-Globin Locus Control Region 5′ Hypersensitive Site 3

1996 • 179 citations

Deletion of the Igκ Light Chain Intronic Enhancer/Matrix Attachment Region Impairs but Does Not Abolish VκJκ Rearrangement

1996 • 172 citations

Inactivation of Myf-6 and Myf-5 genes in mice leads to alterations in skeletal muscle development.

1995 • 172 citations

Deletion of the immunoglobulin kappa chain intron enhancer abolishes kappa chain gene rearrangement in cis but not lambda chain gene rearrangement in trans.

1993 • 168 citations

The Igκ 3′ Enhancer Influences the Ratio of Igκ versus Igλ B Lymphocytes

1996 • 166 citations

Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility.

1996 • 164 citations

Regulation of β-globin gene expression: straightening out the locus

1996 • 146 citations

Class Switching in B Cells Lacking 3′ Immunoglobulin Heavy Chain Enhancers

1998 • 144 citations

The prokaryotic neomycin-resistance-encoding gene acts as a transcriptional silencer in eukaryotic cells

1991 • 139 citations

The mouse IgH 3′‐enhancer

1991 • 139 citations

Structure and expression of germ line immunoglobulin gamma 2b transcripts.

1988 • 136 citations

Expression of immunoglobulin heavy chain at a high level in the absence of a proposed immunoglobulin enhancer element in cis.

1984 • 135 citations

Inactivation of the human beta-globin gene by targeted insertion into the beta-globin locus control region.

1992 • 117 citations

An enhancer at the 3′ end of the mouse immunoglobulin heavy chain locus

1991 • 116 citations

Replacement of germ-line epsilon promoter by gene targeting alters control of immunoglobulin heavy chain class switching.

1993 • 114 citations

An "in-out" strategy using gene targeting and FLP recombinase for the functional dissection of complex DNA regulatory elements: analysis of the beta-globin locus control region.

1993 • 105 citations

Do LCRs Open Chromatin Domains?

1998 • 103 citations

Igf2 imprinting does not require its own DNA methylation or H19 RNA

1998 • 101 citations

The Immunoglobulin Heavy Chain Locus Contains Another B-Cell-Specific 3' Enhancer Close to the α Constant Region

1993 • 92 citations

IgA class switch in I alpha exon-deficient mice. Role of germline transcription in class switch recombination.

1996 • 90 citations

Humoral immune functions in IL-4 transgenic mice.

1991 • 86 citations

Independent immunoglobulin class-switch events occurring in a single myeloma cell line.

1985 • 81 citations

3′ IgH Enhancer Elements Shift Synergistic Interactions During B Cell Development

1998 • 77 citations

Structure and expression of germline immunoglobulin γ³ heavy chain gene transcripts: implications for mitogen and lymphokine directed class-switching

1990 • 76 citations

Switch region content of hybridomas: the two spleen cell Igh loci tend to rearrange to the same isotype.

1987 • 71 citations

Frequency of immunoglobulin E class switching is autonomously determined and independent of prior switching to other classes.

1994 • 70 citations

Deletion of the IgH intronic enhancer and associated matrix-attachment regions decreases, but does not abolish, class switching at the mu locus

1998 • 66 citations

An expressed neo(r) cassette provides required functions of the 1gamma2b exon for class switching

1998 • 48 citations

Iα exon-replacement mice synthesize a spliced HPRT–Cα transcript which may explain their ability to switch to IgA. Inhibition of switching to IgG in these mice

1999 • 38 citations

Structure and Expression of Germ Line Immunoglobulin γ2b Transcripts

1988 • 36 citations

Independent Immunoglobulin Class-Switch Events Occurring in a Single Myeloma Cell Line

1985 • 32 citations

Murine and Human 3′ IgH Regulatory Sequences

1997 • 29 citations