Independent immunoglobulin class-switch events occurring in a single myeloma cell line.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments

1982 • 3,041 citations

A system for shotgun DNA sequencing

1981 • 2,710 citations

A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes

1983 • 1,449 citations

A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene

1983 • 1,418 citations

Charon Phages: Safer Derivatives of Bacteriophage Lambda for DNA Cloning

1977 • 951 citations

Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells.

1983 • 457 citations

Cosmids: a type of plasmid gene-cloning vector that is packageable in vitro in bacteriophage lambda heads.

1978 • 352 citations

In vitro packaging of a λ Dam vector containing EcoRI DNA fragments of Escherichia coli and phage P1

1977 • 319 citations

SYNTHESIS, ASSEMBLY, AND SECRETION OF GAMMA GLOBULIN BY MOUSE MYELOMA CELLS

1970 • 284 citations

5′ Flanking region of immunoglobulin heavy chain constant region genes displays length heterogeneity in germlines of inbred mouse strains

1980 • 238 citations

Switch region of immunoglobulin Cμ gene is composed of simple tandem repetitive sequences

1981 • 173 citations

Immunoglobulin heavy-chain expression and class switching in a murine leukaemia cell line

1982 • 173 citations

Nucleotide sequences of switch regions of immunoglobulin C epsilon and C gamma genes and their comparison.

1982 • 157 citations

Changes in gene position are accompanied by a change in time of replication

1984 • 147 citations

Construction and characterization of the hybrid bacteriophage lambda Charon vectors for DNA cloning

1979 • 131 citations

Rapid isolation of cloned isotype switch variants using fluorescence activated cell sorting

1982 • 112 citations

On immunoglobulin heavy chain gene switching: two γ2b genes are rearranged via switch sequences in MPC-11 cells but only one is expressed

1982 • 107 citations

Immunoglobulin heavy-chain class switching in a pre-B cell line is accompanied by DNA rearrangement

1983 • 105 citations

Ordering of mouse immunoglobulin heavy chain genes by molecular cloning

1981 • 101 citations

Isolation of variants of mouse myeloma X63 that express changed immunoglobulin class.

1980 • 101 citations

Structure of a rearranged gamma 1 chain gene and its implication to immunoglobulin class-switch mechanism.

1981 • 99 citations

Mutations in Immunoglobulin-Producing Moose Myeloma Cells

1973 • 99 citations

Variants of a mouse myeloma cell line that synthesize immunoglobulin heavy chains having an altered serotype.

1975 • 84 citations

Specific duplex formation in vitro of mammalian DNA

1965 • 71 citations

Isolation of myeloma variants with predefined variant surface immunoglobulin by cell sorting.

1978 • 65 citations

DNA sequence analysis on the IBM-PC

1984 • 61 citations

Isotype switching in murine pre-B cell lines

1983 • 55 citations

Products of a reciprocal chromosome translocation involving the c-myc gene in a murine plasmacytoma.

1984 • 55 citations

Spontaneous Immunoglobulin Class Switching in Myeloma and Hybridoma Cell Lines Differs from Physiological Class Switching

1982 • 53 citations

IgG2a-producing variants of an IgG2b-producing mouse myeloma cell line.

1978 • 48 citations

Sequentially Derived Mutants of the Constant Region of the Heavy Chain of Murine Immunoglobulins

1979 • 39 citations

DNA rearrangements in MPC-11 immunoglobulin heavy chain class-switch variants.

1982 • 39 citations

Illegitimate recombination generates a class switch from C mu to C delta in an IgD-secreting plasmacytoma.

1984 • 36 citations

Primary and secondary variants in immunoglobulin heavy chain production

1976 • 31 citations

Rearrangements between the immunoglobulin heavy chain gene JH and Cµ regions accompany normal B lymphocyte differentiation in vitro

1982 • 29 citations

Immunoglobulin Heavy Chain Switching in Cultured I.29 Murine B Lymphoma Cells: Commitment to an IgA or IgE Switch

1984 • 28 citations

Immunoglobulin heavy chain class switch from IgM to IgG in a hybridoma

1983 • 28 citations

New views of the immunoglobulin heavy-chain switch

1982 • 28 citations