A V(D)J Recombinase-Inducible B-Cell Line: Role of Transcriptional Enhancer Elements in Directing V(D)J Recombination

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

1985 • 2,145 citations

RAG-1 and RAG-2, Adjacent Genes That Synergistically Activate V(D)J Recombination

1990 • 1,450 citations

The V(D)J recombination activating gene, RAG-1

1989 • 1,164 citations

Introduced T cell receptor variable region gene segments recombine in pre-B cells: Evidence that B and T cells use a common recombinase

1986 • 452 citations

Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcription

1989 • 432 citations

Regulation of Genome Rearrangement Events during Lymphocyte Differentiation

1986 • 422 citations

Molecular and cellular origins of B lymphocyte diversity

1991 • 346 citations

Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals

1987 • 346 citations

Recombination between immunoglobulin variable region gene segments is enhanced by transcription

1986 • 308 citations

VDJ recombination

1992 • 307 citations

Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate.

1990 • 224 citations

V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer.

1993 • 219 citations

Regulation of V(D)J Recombination Activator Protein RAG-2 by Phosphorylation

1993 • 209 citations

Developmental stage specificity of the lymphoid V(D)J recombination activity.

1987 • 199 citations

Two dominant-acting selectable markers for gene transfer studies in mammalian cells.

1988 • 184 citations

Molecular Aspects of Cellular Regulation

1986 • 168 citations

Enhancers: Mechanisms of Action and Cell Specificity

1988 • 159 citations

MECHANISM AND DEVELOPMENTAL PROGRAM OF IMMUNOGLOBULIN GENE REARRANGEMENT IN MAMMALS

1989 • 144 citations

Transcription-induced nucleosome ‘splitting’: an underlying structure for DNase I sensitive chromatin.

1991 • 142 citations

Inducible overproduction of the mouse c-myc protein in mammalian cells.

1986 • 138 citations

I region-restricted antigen presentation by B cell–B lymphoma hybridomas

1982 • 74 citations

V(D)J recombination activity in lymphoid cell lines is increased by agents that elevate cAMP.

1990 • 64 citations

A novel regulatory myosin light chain gene distinguishes pre-B cell subsets and is IL-7 inducible.

1992 • 45 citations

Comparison of RAG gene expression in normal and transformed precursor lymphocytes

1993 • 15 citations