A diverse set of oligomeric class II MHC-peptide complexes for probing T-cell receptor interactions

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

1999 • 3,025 citations

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide

1994 • 1,553 citations

MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation

1994 • 1,448 citations

Serial triggering of many T-cell receptors by a few peptide–MHC complexes

1995 • 1,143 citations

MECHANISMS OF MHC CLASS I–RESTRICTED ANTIGEN PROCESSING

1998 • 1,017 citations

Determination of sulfhydryl groups with 2,2′- or 4,4′-dithiodipyridine

1967 • 978 citations

LIGAND RECOGNITION BY αβ T CELL RECEPTORS

1998 • 904 citations

On the attribution and additivity of binding energies

1981 • 902 citations

The cytoplasmic domain of the T cell receptor ζ chain is sufficient to couple to receptor-associated signal transduction pathways

1991 • 782 citations

CAPTURE AND PROCESSING OF EXOGENOUS ANTIGENS FOR PRESENTATION ON MHC MOLECULES

1997 • 779 citations

Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size

1992 • 763 citations

HLA-A2-peptide complexes: refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides.

1992 • 684 citations

Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells.

1983 • 654 citations

A brief survey of methods for preparing protein conjugates with dyes, haptens and crosslinking reagents

1992 • 561 citations

T cell antigen receptor signal transduction: A tale of tails and cytoplasmic protein-tyrosine kinases

1993 • 552 citations

The T Cell Receptor as a Multicomponent Signalling Machine: CD4/CD8 Coreceptors and CD45 in T Cell Activation

1992 • 539 citations

STRUCTURAL BASIS OF T CELL RECOGNITION

1999 • 518 citations

Chemistry of Protein Conjugation and Cross Linking

1991 • 490 citations

Detection of Antigen-Specific T Cells with Multivalent Soluble Class II MHC Covalent Peptide Complexes

1998 • 465 citations

The CD69 receptor: a multipurpose cell-surface trigger for hematopoietic cells

1994 • 457 citations

THE DYNAMICS OF T CELL RECEPTOR SIGNALING: Complex Orchestration and the Key Roles of Tempo and Cooperation

1999 • 439 citations

Initiation of Signal Transduction through the T Cell Receptor Requires the Multivalent Engagement of Peptide/MHC Ligands

1998 • 379 citations

Strength in numbers: non-natural polyvalent carbohydrate derivatives

1996 • 375 citations

Four A6-TCR/Peptide/HLA-A2 Structures that Generate Very Different T Cell Signals Are Nearly Identical

1999 • 366 citations

Sequence requirements for induction of cytolysis by the T cell antigenFc receptor ζ chain

1992 • 333 citations

THE MULTI-SUBUNIT INTERLEUKIN-2 RECEPTOR

1989 • 323 citations

A Trivalent System from Vancomycin· <scp>d</scp> -Ala- <scp>d</scp> -Ala with Higher Affinity Than Avidin·Biotin

1998 • 313 citations

T-cell and basophil activation through the cytoplasmic tail of T-cell-receptor zeta family proteins.

1991 • 307 citations

The human class II MHC protein HLA-DR1 assembles as empty αβ heterodimers in the absence of antigenic peptide

1992 • 306 citations

Monoclonal antibodies: Purification, fragmentation and application to structural and functional studies of class I MHC antigens

1982 • 283 citations

The Relationship of MHC-Peptide Binding and T Cell Activation Probed Using Chemically Defined MHC Class II Oligomers

2000 • 254 citations

Ligand-specific oligomerization of T-cell receptor molecules

1997 • 232 citations

Qualitative and Quantitative Differences in T Cell Receptor Binding of Agonist and Antagonist Ligands

1999 • 226 citations

Human T-cell clones recognize chemically synthesized peptides of influenza haemagglutinin

1982 • 224 citations

Preparation and Characterization of Poly(ethylene glycol) Vinyl Sulfone

1996 • 170 citations

T-cell signaling: The importance of receptor clustering

1997 • 155 citations

The class II MHC protein HLA-DR1 in complex with an endogenous peptide: implications for the structural basis of the specificity of peptide binding

1997 • 154 citations

High-affinity binding of an influenza hemagglutinin-derived peptide to purified HLA-DR.

1990 • 148 citations

Multivalent structure of an αβT cell receptor

1999 • 140 citations

Ligands for the T-cell receptor: hard times for avidity models

1995 • 138 citations

MHC superfamily structure and the immune system

1999 • 110 citations

Potent T Cell Activation with Dimeric Peptide–Major Histocompatibility Complex Class II Ligand: The Role of CD4 Coreceptor

1998 • 106 citations

Dimerization of soluble major histocompatibility complex-peptide complexes is sufficient for activation of T cell hybridoma and induction of unresponsiveness.

1995 • 101 citations

Empty and Peptide-Loaded Class II Major Histocompatibility Complex Proteins Produced by Expression inEscherichia coliand Foldingin Vitro

1999 • 97 citations

Streptavidin contains an RYD sequence which mimics the RGD receptor domain of fibronectin

1990 • 90 citations

Human IgG Fc Receptors

1997 • 89 citations

A Conformational Change in the Human Major Histocompatibility Complex Protein HLA-DR1 Induced by Peptide Binding

1999 • 83 citations

Sites of interaction in the complex between beta- and gamma-subunits of transducin.

1990 • 74 citations

Kinetics of T-cell Receptor Binding by Bivalent HLA-DR·Peptide Complexes That Activate Antigen-specific Human T-cells

2000 • 68 citations

Biophysical studies of T-cell receptors and their ligands

1996 • 66 citations

Antigen-Specific Signaling by a Soluble, Dimeric Peptide/Major Histocompatibility Complex Class II/Fc Chimera Leading to T Helper Cell Type 2 Differentiation

1999 • 63 citations

Detection of Dimers of Dimers of Human Leukocyte Antigen (HLA)–DR on the Surface of Living Cells by Single-Particle Fluorescence Imaging

1998 • 62 citations

A Three-Step Kinetic Mechanism for Peptide Binding to MHC Class II Proteins

2000 • 62 citations

The structure of MHC class II: a role for dimer of dimers

1995 • 49 citations

Structure and function of the T-cell receptor: insights from X-ray crystallography

1996 • 47 citations

Activation requirements for normal T cells: accessory cell-dependent and -independent stimulation by anti-receptor antibodies.

1986 • 46 citations

Biophysical Aspects of Antigen Recognition by T Cells

1987 • 44 citations

Inhibition or activation of human T cell receptor transfectants is controlled by defined, soluble antigen arrays.

1992 • 44 citations

Conformation of Human Leukocyte Antigen Class II Molecules

1996 • 33 citations

The assembly and stability of MHC class II-(alpha beta)2 superdimers.

1998 • 21 citations

The Assembly and Stability of MHC Class II-(αβ)2 Superdimers

1998 • 18 citations

The T-Cell Antigen Receptor: A Multisubunit Signaling Complex

1994 • 18 citations

A mutant human β2-microglobulin can be used to generate diverse multimeric class I peptide complexes as specific probes for T cell receptors

1998 • 7 citations