Qualitative and Quantitative Differences in T Cell Receptor Binding of Agonist and Antagonist Ligands

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex

1996 • 1,282 citations

Kinetic proofreading in T-cell receptor signal transduction.

1995 • 931 citations

Evidence that a Single Peptide–MHC Complex on a Target Cell Can Elicit a Cytolytic T Cell Response

1996 • 684 citations

T-cell-receptor affinity and thymocyte positive selection

1996 • 620 citations

Two Human T Cell Receptors Bind in a Similar Diagonal Mode to the HLA-A2/Tax Peptide Complex Using Different TCR Amino Acids

1998 • 438 citations

A TCR Binds to Antagonist Ligands with Lower Affinities and Faster Dissociation Rates Than to Agonists

1996 • 430 citations

Initiation of Signal Transduction through the T Cell Receptor Requires the Multivalent Engagement of Peptide/MHC Ligands

1998 • 379 citations

Essential flexibility in the T-cell recognition of antigen

1996 • 330 citations

CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes

1996 • 326 citations

Crystal structure of the major histocompatibility complex class I H-2Kb molecule containing a single viral peptide: implications for peptide binding and T-cell receptor recognition.

1992 • 295 citations

Kinetic discrimination in T-cell activation.

1996 • 286 citations

Kinetics and affinity of reactions between an antigen-specific T cell receptor and peptide-MHC complexes

1994 • 253 citations

Immobilization chemistries suitable for use in the BIAcore surface plasmon resonance detector

1992 • 247 citations

CD8 modulation of T-cell antigen receptor–ligand interactions on living cytotoxic T lymphocytes

1995 • 245 citations

Ligand-specific oligomerization of T-cell receptor molecules

1997 • 232 citations

Kinetics of ligand binding to receptor immobilized in a polymer matrix, as detected with an evanescent wave biosensor. I. A computer simulation of the influence of mass transport

1996 • 232 citations

Specificity and flexibility in thymic selection

1994 • 221 citations

Real-Time Competitive Kinetic Analysis of Interactions between Low-Molecular-Weight Ligands in Solution and Surface-Immobilized Receptors

1994 • 208 citations

High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins.

1994 • 200 citations

Crystal Structure of the V _α Domain of a T Cell Antigen Receptor

1995 • 178 citations

Strong agonist ligands for the T cell receptor do not mediate positive selection of functional CD8+ T cells

1995 • 161 citations

Assembly, specific binding, and crystallization of a human TCR-alphabeta with an antigenic Tax peptide from human T lymphotropic virus type 1 and the class I MHC molecule HLA-A2.

1996 • 153 citations

Ligands for the T-cell receptor: hard times for avidity models

1995 • 138 citations

Real-time measurements of kinetics of EGF binding to soluble EGF receptor monomers and dimers support the dimerization model for receptor activation

1993 • 129 citations

Lack of strict correlation of functional sensitization with the apparent affinity of MHC/peptide complexes for the TCR.

1995 • 121 citations

CD8 Expression Allows T Cell Signaling by Monomeric Peptide-MHC Complexes

1998 • 119 citations

Peptide Antagonism and T Cell Receptor Interactions with Peptide-MHC Complexes

1998 • 118 citations

Identification of conserved T cell receptor CDR3 residues contacting known exposed peptide side chains from a major histocompatibility complex class I‐bound determinant

1993 • 116 citations

CD4 Augments the Response of a T Cell to Agonist but Not to Antagonist Ligands

1997 • 114 citations

Correlation Between the Number of T Cell Receptors Required for T Cell Activation and TCR–Ligand Affinity

1996 • 103 citations

Variant TCR ligands: new insights into the molecular basis of antigen-dependent signal transduction and T-cell activation

1996 • 99 citations

Assembly of the TCR/CD3 complex: CD3ε/δ and CD3ε/γ dimers associate indistinctly with both TCRα and TCRβ chains. Evidence for a double TCR heterodimer model

1998 • 94 citations

Positive selection of CD4+T cells by TCR ligation without aggregation even in the absence of MHC

1994 • 83 citations

Surface plasmon resonance based methods for measuring the kinetics and binding affinities of biomolecular interactions

1994 • 75 citations

Evidence for multivalent structure of T-cell antigen receptor complex

1995 • 72 citations

Aggregation of IgE-receptor complexes on rat basophilic leukemia cells does not change the intrinsic affinity but can alter the kinetics of the ligand-IgE interaction

1992 • 64 citations

CD3 Ligation on Immature Thymocytes Generates Antagonist-like Signals Appropriate for CD8 Lineage Commitment, Independently of T Cell Receptor Specificity

1998 • 59 citations

Degree of TCR Internalization and Ca2+ Flux Correlates with Thymocyte Selection

1998 • 50 citations

Limits to the differential avidity model of T cell selection in the thymus.

1997 • 48 citations

Identification and Minimization of Nonideal Binding Effects in BIAcore Analysis: Ferritin/Anti-ferritin Fab′ Interaction as a Model System

1997 • 41 citations

A residue in the center of peptide QL9 affects binding to both Ld and the T cell receptor.

1996 • 35 citations