Structure and function of the T-cell receptor: insights from X-ray crystallography

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Sequences of proteins of immunological interest

1984 • 3,427 citations

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

1992 • 2,236 citations

Dimerization of cell surface receptors in signal transduction

1995 • 1,631 citations

MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation

1994 • 1,448 citations

Canonical structures for the hypervariable regions of immunoglobulins

1987 • 1,357 citations

Structural basis of cell-cell adhesion by cadherins

1995 • 1,173 citations

Serial triggering of many T-cell receptors by a few peptide–MHC complexes

1995 • 1,143 citations

Crystal Structures of Two Viral Peptides in Complex with Murine MHC Class I H-2K ^b

1992 • 864 citations

ANTIBODY-ANTIGEN COMPLEXES

1990 • 853 citations

The cytoplasmic domain of the T cell receptor ζ chain is sufficient to couple to receptor-associated signal transduction pathways

1991 • 782 citations

The Immunoglobulin Fold

1994 • 679 citations

The outline structure of the T-cell alpha beta receptor.

1988 • 625 citations

Partial T cell signaling: Altered phospho-? and lack of zap70 recruitment in APL-induced T cell anergy

1994 • 608 citations

Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen

1994 • 585 citations

Mapping T-cell receptor–peptide contacts by variant peptide immunization of single-chain transgenics

1992 • 531 citations

ζ Phosphorylation Without ZAP-70 Activation Induced by TCR Antagonists or Partial Agonists

1995 • 510 citations

Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation

1990 • 468 citations

Many of the Immunoglobulin Superfamily Domains in Cell Adhesion Molecules and Surface Receptors Belong to a New Structural Set Which is close to That Containing Variable Domains

1994 • 439 citations

Activation of T Cells by a Tyrosine Kinase Activation Domain in the Cytoplasmic Tail of CD3 ε

1992 • 430 citations

Analysis and Expression of a Cloned Pre-T Cell Receptor Gene

1994 • 410 citations

T cell activation by clustered tyrosine kinases

1993 • 379 citations

Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor

1995 • 349 citations

T Cell Receptor-MHC Class I Peptide Interactions: Affinity, Kinetics, and Specificity

1994 • 292 citations

Crystal Structure of the β Chain of a T Cell Antigen Receptor

1995 • 267 citations

Expression of T Cell Antigen Receptor Heterodimers in a Lipid-Linked Form

1990 • 224 citations

Specific low-affinity recognition of major histocompatibility complex plus peptide by soluble T-cell receptor

1992 • 221 citations

Transient intercellular adhesion: the importance of weak protein-protein interactions

1994 • 213 citations

Implications of a Fab-like structure for the T-cell receptor

1989 • 193 citations

Binary and ternary complexes between T-cell receptor, class II MHC and superantigen in vitro

1994 • 182 citations

Crystal Structure of the V _α Domain of a T Cell Antigen Receptor

1995 • 178 citations

Staphylococcal enterotoxin A has two cooperative binding sites on major histocompatibility complex class II.

1995 • 174 citations

Characterization of two distinct MHC class II binding sites in the superantigen staphylococcal enterotoxin A.

1995 • 163 citations

The fourth immunoglobulin domain of the stem cell factor receptor couples ligand binding to signal transduction

1995 • 160 citations

Dimerization and activation of the kit receptor by monovalent and bivalent binding of the stem cell factor.

1992 • 151 citations

Ligands for the T-cell receptor: hard times for avidity models

1995 • 138 citations

Superantigen binding to a T cell receptor beta chain of known three-dimensional structure.

1995 • 124 citations

Cross-linking of major histocompatibility complex class II molecules by staphylococcal enterotoxin A superantigen is a requirement for inflammatory cytokine gene expression.

1995 • 122 citations

Dimerization of soluble major histocompatibility complex-peptide complexes is sufficient for activation of T cell hybridoma and induction of unresponsiveness.

1995 • 101 citations

An MHC interaction site maps to the amino-terminal half of the T cell receptor α chain variable domain

1992 • 100 citations

High-Efficiency Expression and Solubilization of Functional T Cell Antigen Receptor Heterodimers

1992 • 73 citations

Secretion of T cell receptor fragments from recombinant Escherichia coli cells

1992 • 67 citations

High sensitivity, low affinity—paradox of T-cell receptor recognition

1994 • 54 citations

Secretion of a homodimeric V±CΚ T-cell receptor-immunoglobulin chimeric protein

1989 • 27 citations