The Assembly and Stability of MHC Class II-(αβ)2 Superdimers

Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.

1977 • 5,640 citations

T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity

1978 • 3,314 citations

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide

1994 • 1,553 citations

MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation

1994 • 1,448 citations

An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex

1996 • 1,282 citations

Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens.

1980 • 850 citations

The Three-Dimensional Structure of Peptide-MHC Complexes

1995 • 817 citations

Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen

1994 • 585 citations

The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3

1995 • 583 citations

MHC class II-associated invariant chain contains a sorting signal for endosomal compartments

1990 • 565 citations

Intracellular transport of class II MHC molecules directed by invariant chain

1990 • 548 citations

Chemical probes of extended biological structures: Synthesis and properties of the cleavable protein cross-linking reagent [35S]dithiobis(succinimidyl propionate)

1976 • 493 citations

Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding

1990 • 486 citations

MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding

1991 • 394 citations

Structures of an MHC Class II Molecule with Covalently Bound Single Peptides

1996 • 369 citations

MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8

1992 • 368 citations

Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain

1991 • 326 citations

Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways

1990 • 303 citations

Toxic Shock Syndrome Toxin-1 Complexed with a Class II Major Histocompatibility Molecule HLA-DR1

1994 • 300 citations

A role for peptide in determining MHC class II structure

1991 • 275 citations

Identification of a CD4 binding site on the β2 domain of HLA-DR molecules

1992 • 272 citations

Crystal Structure of the β Chain of a T Cell Antigen Receptor

1995 • 267 citations

Monoclonal antibody against an Ir gene product?

1980 • 238 citations

Proteolysis of the class II-associated invariant chain generates a peptide binding site in intracellular HLA-DR molecules.

1991 • 234 citations

Ligand-specific oligomerization of T-cell receptor molecules

1997 • 232 citations

Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes.

1992 • 219 citations

Invariant chain can function as a chaperone protein for class II major histocompatibility complex molecules.

1992 • 197 citations

Role of Transmembrane Domain Interactions in the Assembly of Class II MHC Molecules

1992 • 191 citations

Assembly and transport properties of invariant chain trimers and HLA-DR-invariant chain complexes.

1992 • 189 citations

Endosomal aspartic proteinases are required for invariant-chain processing.

1994 • 182 citations

The murine Eα immune response gene

1983 • 180 citations

Crystal Structure of the V _α Domain of a T Cell Antigen Receptor

1995 • 178 citations

Invariant chain cleavage and peptide loading in major histocompatibility complex class II vesicles.

1995 • 150 citations

Invariant chain protects class II histocompatibility antigens from binding intact polypeptides in the endoplasmic reticulum.

1996 • 146 citations

The synthesis of sendai virus polypeptides in infected cells

1977 • 137 citations

Involvement of both major histocompatibility complex class II alpha and beta chains in CD4 function indicates a role for ordered oligomerization in T cell activation.

1995 • 117 citations

Multiple binding sites for bacterial superantigens on soluble class II MHC molecules

1995 • 112 citations

Biosynthesis and maturation of HLA-DR antigens in vivo.

1981 • 111 citations

Structural Intermediates in the Reactions of Antigenic Peptides with MHC Molecules

1989 • 107 citations

Oligomerization of CD4 is required for stable binding to class II major histocompatibility complex proteins but not for interaction with human immunodeficiency virus gp120.

1995 • 94 citations

Molecular recognition of antigen involves lattice formation between CD4, MHC class II and TCR molecules

1995 • 85 citations

Delivery of nascent MHC class II-invariant chain complexes to lysosomal compartments and proteolysis of invariant chain by cysteine proteases precedes peptide binding in B-lymphoblastoid cells.

1995 • 83 citations

Isolation and characterization of a cDNA clone for the murine I-E beta polypeptide chain.

1983 • 81 citations

Purification of HLA-linked B lymphocyte alloantigens in immunologically active form by preparative sodium dodecyl sulfate-gel electrophoresis and studies on their subunit association.

1977 • 79 citations

How MHC class II molecules work: peptide-dependent completion of protein folding

1992 • 75 citations

Cross-reactive idiotypes and common antigen binding specificities expressed by a series of murine B-cell lymphomas: etiological implications.

1985 • 73 citations

Evidence for dimers of MHC class II molecules in B lymphocytes and their role in low affinity T cell responses

1994 • 62 citations

Detection of Dimers of Dimers of Human Leukocyte Antigen (HLA)–DR on the Surface of Living Cells by Single-Particle Fluorescence Imaging

1998 • 62 citations

A structural transition in class II major histocompatibility complex proteins at mildly acidic pH.

1996 • 58 citations

Evidence for a conformational change in a class II major histocompatibility complex molecule occurring in the same pH range where antigen binding is enhanced.

1996 • 56 citations

HLA-DM is present in one-fifth the amount of HLA-DR in the class II peptide-loading compartment where it associates with leupeptin-induced peptide (LIP)-HLA-DR complexes.

1996 • 55 citations

Peptides of 23 residues or greater are required to stimulate a high affinity class II‐restricted T cell response

1993 • 53 citations

The structure of MHC class II: a role for dimer of dimers

1995 • 49 citations

Heat shock enhances antigen processing and accelerates the formation of compact class II alpha beta dimers.

1994 • 47 citations

The Structural Basis of CD4 — MHC Class II Interactions: Coreceptor Contributions to T Cell Receptor Antigen Recognition and Oligomerization-Dependent Signal Transduction

1996 • 42 citations

Conformation of Human Leukocyte Antigen Class II Molecules

1996 • 33 citations

Intracellular transport of invariant chain-MHC class II complexes to the peptide-loading compartment.

1995 • 28 citations

Role of L3T4 and Ia in the heteroclitic response of T cells to cytochrome c.

1986 • 26 citations

Cross-linking of cytochrome oxidase subunits with difluorodinitrobenzene

1980 • 23 citations

N-linked oligosaccharides of murine major histocompatibility complex class II molecule. Role in antigenic peptide binding, T cell recognition, and clonal nonresponsiveness.

1992 • 21 citations

Alteration of a non-polymorphic residue in a class II E beta gene eliminates an antibody-defined epitope without affecting T cell recognition.

1987 • 17 citations

Isolation of a functional antigen-Ia complex.

1990 • 17 citations

Isotypic residues in the membrane proximal domain of MHC class II beta-chains control activation of CD4+ T cells.

1993 • 13 citations

Interactions between the amino-terminal domains of MHC class II molecules have a profound effect on serologic and T cell recognition: an analysis using recombinant HLA-DR/H-2E molecules.

1991 • 12 citations

Mutational analysis of two DR alpha residues involved in dimers of HLA-DR molecules.

1995 • 11 citations

Ek beta mutant antigen-presenting cell lines expressing altered Ak alpha molecules.

1986 • 10 citations