The class II MHC protein HLA-DR1 in complex with an endogenous peptide: implications for the structural basis of the specificity of peptide binding

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

The interpretation of protein structures: Estimation of static accessibility

1971 • 5,771 citations

AMoRe: an automated package for molecular replacement

1994 • 4,990 citations

X-PLOR Version 3.1: A System for X-ray Crystallography and NMR

1992 • 3,488 citations

Cation-π Interactions in Chemistry and Biology: A New View of Benzene, Phe, Tyr, and Trp

1996 • 2,561 citations

Raster3D Version 2.0. A program for photorealistic molecular graphics

1994 • 2,515 citations

Analytical molecular surface calculation

1983 • 2,454 citations

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

Improved Fourier coefficients for maps using phases from partial structures with errors

1986 • 1,897 citations

Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide

1994 • 1,553 citations

Traitement statistique des erreurs dans la determination des structures cristallines

1952 • 1,284 citations

A rapid finite difference algorithm, utilizing successive over‐relaxation to solve the Poisson–Boltzmann equation

1991 • 1,257 citations

A discussion of the solution for the best rotation to relate two sets of vectors

1978 • 1,088 citations

Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 Å resolution

1991 • 1,079 citations

The Biochemistry and Cell Biology of Antigen Processing and Presentation

1993 • 1,022 citations

HLA and Disease Associations

1985 • 893 citations

Automated refinement of protein models

1993 • 893 citations

Crystal Structures of Two Viral Peptides in Complex with Murine MHC Class I H-2K ^b

1992 • 864 citations

The Three-Dimensional Structure of Peptide-MHC Complexes

1995 • 817 citations

Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size

1992 • 763 citations

Amino‐aromatic interactions in proteins

1986 • 752 citations

The three-dimensional structure of HLA-B27 at 2.1 Å resolution suggests a general mechanism for tight peptide binding to MHC

1992 • 670 citations

Peptides Presented to the Immune System by the Murine Class II Major Histocompatibility Complex Molecule I-A _d

1992 • 654 citations

Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen

1994 • 585 citations

The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3

1995 • 583 citations

A binding site for the T-cell co-receptor CD8 on the α3 domain of HLA-A2

1990 • 527 citations

Ribbon models of macromolecules

1987 • 519 citations

Crystal structure of the complex between human CD8αα and HLA-A2

1997 • 471 citations

Promiscuous and allele-specific anchors in HLA-DR-binding peptides

1993 • 383 citations

Chemistry of peptides associated with MHC class I and class II molecules

1995 • 371 citations

Structures of an MHC Class II Molecule with Covalently Bound Single Peptides

1996 • 369 citations

MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8

1992 • 368 citations

Prediction of major histocompatibility complex binding regions of protein antigens by sequence pattern analysis.

1989 • 310 citations

The human class II MHC protein HLA-DR1 assembles as empty αβ heterodimers in the absence of antigenic peptide

1992 • 306 citations

Antigenic peptide binding by class I and class II histocompatibility proteins

1994 • 302 citations

Toxic Shock Syndrome Toxin-1 Complexed with a Class II Major Histocompatibility Molecule HLA-DR1

1994 • 300 citations

Peptide binding to HLA-DR1: a peptide with most residues substituted to alanine retains MHC binding.

1990 • 248 citations

Crystallographic analysis of endogenous peptides associated with HLA-DR1 suggests a common, polyproline II-like conformation for bound peptides.

1996 • 247 citations

On the interaction of promiscuous antigenic peptides with different DR alleles. Identification of common structural motifs.

1991 • 242 citations

Truncation variants of peptides isolated from MHC class II molecules suggest sequence motifs

1992 • 234 citations

Identification of a motif for HLA-DR1 binding peptides using M13 display libraries.

1992 • 224 citations

HLA and disease associations

1986 • 185 citations

Staphylococcal enterotoxin A has two cooperative binding sites on major histocompatibility complex class II.

1995 • 174 citations

The role of aromatic rings as hydrogen-bond acceptors in molecular recognition

1993 • 154 citations

Molecular replacement

1992 • 137 citations

High-affinity binding of short peptides to major histocompatibility complex class II molecules by anchor combinations.

1994 • 127 citations

Identification of the staphylococcal enterotoxin A superantigen binding site in the beta 1 domain of the human histocompatibility antigen HLA-DR.

1991 • 119 citations

The importance of dominant negative effects of amino acid side chain substitution in peptide-MHC molecule interactions and T cell recognition.

1993 • 117 citations

Identification of HLA-DR1 beta chain residues critical for binding staphylococcal enterotoxins A and E.

1992 • 116 citations

HLA-DQ allelic polymorphisms constrain patterns of class II heterodimer formation.

1993 • 110 citations

Amino acid residues that flank core peptide epitopes and the extracellular domains of CD4 modulate differential signaling through the T cell receptor.

1994 • 102 citations

Critical role for the Val/Gly86 HLA-DR beta dimorphism in autoantigen presentation to human T cells.

1991 • 97 citations

Molecular replacement

1992 • 92 citations

Differential effect of polymorphism at HLA-DR1 beta-chain positions 85 and 86 on binding and recognition of DR1-restricted antigenic peptides.

1993 • 63 citations

Structural requirements for pairing of alpha and beta chains in HLA-DR and HLA-DP molecules.

1990 • 32 citations

Sequences in both class II major histocompatibility complex alpha and beta chains contribute to the binding of the superantigen toxic shock syndrome toxin 1.

1992 • 29 citations

T cell recognition of MHC class II-associated peptides is independent of peptide affinity for MHC and sodium dodecyl sulfate stability of the peptide/MHC complex. Effects of conservative amino acid substitutions at anchor position 1 of influenza matrix protein19-31.

1996 • 22 citations