Kinetics of T-cell Receptor Binding by Bivalent HLA-DR·Peptide Complexes That Activate Antigen-specific Human T-cells

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

1999 • 3,025 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

Cell lines derived from late embryonic stages of Drosophila melanogaster

1972 • 1,215 citations

Fcγ Receptor–mediated Induction of Dendritic Cell Maturation and Major Histocompatibility Complex Class I–restricted Antigen Presentation after Immune Complex Internalization

1999 • 898 citations

OKT3: A monoclonal anti-human T lymphocyte antibody with potent mitogenic properties

1980 • 718 citations

The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes.

1988 • 716 citations

Erythropoietin Receptor Activation by a Ligand-Induced Conformation Change

1999 • 624 citations

Crystallographic Evidence for Preformed Dimers of Erythropoietin Receptor Before Ligand Activation

1999 • 597 citations

OKT3: a monoclonal anti-human T lymphocyte antibody with potent mitogenic properties.

1980 • 525 citations

Characterization and use of theDrosophilametallothionein promoter in culturedDrosophila melanogastercells

1988 • 440 citations

The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules

1992 • 438 citations

Antigen-like effects of monoclonal antibodies directed at receptors on human T cell clones.

1983 • 435 citations

Oligomerization of epidermal growth factor receptors on A431 cells studied by time-resolved fluorescence imaging microscopy. A stereochemical model for tyrosine kinase receptor activation.

1995 • 432 citations

Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness.

1994 • 431 citations

A TCR Binds to Antagonist Ligands with Lower Affinities and Faster Dissociation Rates Than to Agonists

1996 • 430 citations

Initiation of Signal Transduction through the T Cell Receptor Requires the Multivalent Engagement of Peptide/MHC Ligands

1998 • 379 citations

Failure to synthesize the T Cell CD3-? chain: Structure and function of a partial T cell receptor complex

1988 • 351 citations

Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones.

1994 • 323 citations

High- and Low-Potency Ligands with Similar Affinities for the TCR

1998 • 322 citations

Production of soluble MHC class II proteins with covalently bound single peptides

1994 • 302 citations

T Cell Receptor-MHC Class I Peptide Interactions: Affinity, Kinetics, and Specificity

1994 • 292 citations

Colocalized transmembrane determinants for ER degradation and subunit assembly explain the intracellular fate of TCR chains

1990 • 266 citations

Dimeric association and segmental variability in the structure of human CD4

1997 • 266 citations

Structural basis for major histocompatibility complex (MHC)-linked susceptibility to autoimmunity: charged residues of a single MHC binding pocket confer selective presentation of self-peptides in pemphigus vulgaris.

1995 • 241 citations

Type I (CD64) and type II (CD32) Fc gamma receptor-mediated phagocytosis by human blood dendritic cells.

1996 • 235 citations

CD3delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage

1997 • 209 citations

Crystallographic Evidence for Dimerization of Unliganded Tumor Necrosis Factor Receptor

1995 • 180 citations

The CD3γ chain is essential for development of both the TCRαβ and TCRγδ lineages

1998 • 158 citations

Multivalent structure of an αβT cell receptor

1999 • 140 citations

Preassembly of interleukin 2 (IL-2) receptor subunits on resting Kit 225 K6 T cells and their modulation by IL-2, IL-7, and IL-15: A fluorescence resonance energy transfer study

1997 • 130 citations

Structure of the T cell antigen receptor (TCR): two CD3 epsilon subunits in a functional TCR/CD3 complex.

1991 • 129 citations

Structure of the T-cell antigen receptor: evidence for two CD3 epsilon subunits in the T-cell receptor-CD3 complex.

1990 • 110 citations

Vectors containing a prokaryotic dihydrofolate reductase gene transform Drosophila cells to methotrexate-resistance.

1983 • 109 citations

Potent T Cell Activation with Dimeric Peptide–Major Histocompatibility Complex Class II Ligand: The Role of CD4 Coreceptor

1998 • 106 citations

Analysis of the T-cell receptor repertoire of human T-cell leukemia virus type 1 (HTLV-1) Tax-specific CD8+ cytotoxic T lymphocytes from patients with HTLV-1-associated disease: evidence for oligoclonal expansion

1996 • 106 citations

Dimerization of soluble major histocompatibility complex-peptide complexes is sufficient for activation of T cell hybridoma and induction of unresponsiveness.

1995 • 101 citations

In Vitro Translation and Assembly of a Complete T Cell Receptor–CD3 Complex

1997 • 100 citations

Expression of Recombinant HLA-DR2 Molecules

1996 • 99 citations

Lysine 271 in the transmembrane domain of the T-cell antigen receptor beta chain is necessary for its assembly with the CD3 complex but not for alpha/beta dimerization.

1990 • 92 citations

Assembly and function of the T cell antigen receptor. Requirement of either the lysine or arginine residues in the transmembrane region of the alpha chain.

1990 • 84 citations

Chapter 9 Transformation Techniques for Drosophila Cell Lines

1994 • 77 citations

The T cell antigen receptor α and β chains interact via distinct regions with CD3 chains

1994 • 77 citations

TCRα-CD3δϵ association is the initial step in αβ dimer formation in murine T cells and is limiting in immature CD4+CD8+ thymocytes

1995 • 71 citations

Antigen-Specific Signaling by a Soluble, Dimeric Peptide/Major Histocompatibility Complex Class II/Fc Chimera Leading to T Helper Cell Type 2 Differentiation

1999 • 63 citations

Structure, assembly and intracellular transport of the T cell receptor for antigen.

1991 • 59 citations

T cell receptor aggregation, but not dimerization, induces increased cytosolic calcium concentrations and reveals a lack of stable association between CD4 and the T cell receptor.

1992 • 42 citations

Comparison of mouse immunoglobulin gamma 2a and gamma 2b chain genes suggests that exons can be exchanged between genes in a multigenic family.

1981 • 41 citations

Analysis of the Expression of Peptide–Major Histocompatibility Complexes Using High Affinity Soluble Divalent T Cell Receptors

1997 • 40 citations

Expression and crystallization of the complex of HLA-DR2 (DRA, DRB1*1501) and an immunodominant peptide of human myelin basic protein

1998 • 39 citations

T lymphocyte development in the absence of CD3 epsilon or CD3 gamma delta epsilon zeta.

1999 • 36 citations

T Lymphocyte Development in the Absence of CD3ε or CD3γδεζ

1999 • 35 citations

Electron microscopic and hydrodynamic studies of protein A-immunoglobulin G soluble complexes.

1984 • 21 citations

Generation of antigen-specific cytotoxic T lymphocytes and regulation of cytokine production takes place in the absence of CD3zeta

1999 • 9 citations

[14] Fluorescence-activated cell sorting of hybrid and transfected cells

1987 • 2 citations