DNA-dependent Protein Kinase Protects against Heat-induced Apoptosis

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 2,129 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen

1993 • 1,219 citations

Role of the Human Heat Shock Protein hsp70 in Protection against Stress-Induced Apoptosis

1997 • 961 citations

Acid Sphingomyelinase–Deficient Human Lymphoblasts and Mice Are Defective in Radiation-Induced Apoptosis

1996 • 795 citations

Induction of sequence-specific binding of Drosophila heat shock activator protein without protein synthesis

1987 • 382 citations

Sequential Phosphorylation by Mitogen-activated Protein Kinase and Glycogen Synthase Kinase 3 Represses Transcriptional Activation by Heat Shock Factor-1

1996 • 381 citations

Thermally Enhanced Radioresponse of Cultured Chinese Hamster Cells: Inhibition of Repair of Sublethal Damage and Enhancement of Lethal Damage

1974 • 375 citations

Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II.

1992 • 367 citations

Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids

1998 • 361 citations

Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse.

1996 • 349 citations

X-ray-sensitive mutants of Chinese hamster ovary cell line isolation and cross-sensitivity to other DNA-damaging agents

1983 • 345 citations

Characterization of the DNA-binding protein antigen Ku recognized by autoantibodies from patients with rheumatic disorders.

1986 • 333 citations

Repression of the Heat Shock Factor 1 Transcriptional Activation Domain Is Modulated by Constitutive Phosphorylation

1997 • 316 citations

Cell Death Induced in a Murine Mastocytoma by 42–47°C Heatingin Vitro: Evidence that the Form of Death Changes from Apoptosis to Necrosis Above a Critical Heat Load

1990 • 316 citations

Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1

1998 • 302 citations

Sequence and organization of genes encoding the human 27 kDa heat shock protein

1986 • 299 citations

The DNA-dependent Protein Kinase Is Inactivated by Autophosphorylation of the Catalytic Subunit

1996 • 287 citations

Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells.

1995 • 286 citations

Double Strand Break Repair

1997 • 268 citations

The Elk-1 ETS-Domain Transcription Factor Contains a Mitogen-Activated Protein Kinase Targeting Motif

1998 • 265 citations

Functional interaction between DNA-PK and c-Abl in response to DNA damage

1997 • 254 citations

Interaction of Hyperthermia and Radiation in CHO Cells: Recovery Kinetics

1976 • 238 citations

Stimulation of the DNA-dependent Protein Kinase by Poly(ADP-Ribose) Polymerase

1998 • 237 citations

Repression of human heat shock factor 1 activity at control temperature by phosphorylation.

1996 • 231 citations

Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice

1997 • 196 citations

Characterization and sequence of a mouse hsp70 gene and its expression in mouse cell lines

1990 • 187 citations

Biochemical and Genetic Defects in the DNA-Dependent Protein Kinase in Murine scid Lymphocytes

1996 • 185 citations

The Role of Apoptosis in the Response of Cells and Tumours to Mild Hyperthermia

1991 • 176 citations

Molecular and Biochemical Characterization of xrs Mutants Defective in Ku80

1997 • 174 citations

DNA-dependent protein kinase (Ku protein-p350 complex) assembles on double-stranded DNA.

1994 • 168 citations

Glycogen Synthase Kinase 3β and Extracellular Signal-Regulated Kinase Inactivate Heat Shock Transcription Factor 1 by Facilitating the Disappearance of Transcriptionally Active Granules after Heat Shock

1998 • 162 citations

Hyperthermia Induces Apoptosis in Thymocytes

1991 • 158 citations

DNA binding of heat shock factor to the heat shock element is insufficient for transcriptional activation in murine erythroleukemia cells.

1990 • 143 citations

Apoptosis in tumors and normal tissues induced by whole body hyperthermia in rats.

1995 • 139 citations

The effects of hyperthermia on mammalian cell structure and function

1992 • 135 citations

Differences in target cell DNA fragmentation induced by mouse cytotoxic T lymphocytes and natural killer cells.

1986 • 102 citations

Double‐strand break repair mediated by DNA end‐joining

1998 • 99 citations

DNA double-strand-break sensitivity, DNA replication, and cell cycle arrest phenotypes of Ku-deficient Saccharomyces cerevisiae

1997 • 99 citations

Ceramide formation during heat shock: a potential mediator of alpha B-crystallin transcription.

1995 • 98 citations

Analysis of the phosphorylation of human heat shock transcription factor-1 by MAP kinase family members

1997 • 92 citations

Sequence-specific DNA Binding and Transcription Factor Phosphorylation by Ku Autoantigen/DNA-dependent Protein Kinase

1997 • 81 citations

Kinetic and Physical Studies of Cell Death Induced By Chemotherapeutic Agents Or Hyperthermia

1986 • 79 citations

p95^vavAssociates with the Nuclear Protein Ku-70

1996 • 79 citations

Thermal Sensitivity and the Effect of Elevated Temperatures on the Radiation Sensitivity of Chinese Hamster Cells

1974 • 78 citations

A Constitutive Heat Shock Element-binding Factor Is Immunologically Identical to the Ku Autoantigen

1995 • 75 citations

Disruption of DNA-PK in Ku80 mutant xrs-6 and the implications in DNA double-strand break repair

1996 • 72 citations

DNA-Dependent Protein Kinase Phosphorylation of IκBα and IκBβ Regulates NF-κB DNA Binding Properties

1998 • 72 citations

Stimulation of the DNA-dependent Protein Kinase by RNA Polymerase II Transcriptional Activator Proteins

1995 • 66 citations

The Occurrence of DNA Strand Breaks after Hyperthermic Treatments of Mammalian Cells with and without Radiation

1984 • 65 citations

Analysis by Pulsed-field Gel Electrophoresis of DNA Double-strand Breaks Induced by Heat and/or X-irradiation in Bulk and Replicating DNA of CHO Cells

1995 • 65 citations

Suppression of heat-induced hsp70 expression by the 70-kDa subunit of the human Ku autoantigen.

1995 • 56 citations

Heat Shock Transcription Factor 1 Binds Selectively in Vitro to Ku Protein and the Catalytic Subunit of the DNA-dependent Protein Kinase

1997 • 52 citations

A Possible Mechanism for Hyperthermic Radiosensitization Mediated through Hyperthermic Lability of Ku Subunits in DNA-Dependent Protein Kinase

1997 • 50 citations

Modulation of Thermal Induction of hsp70 Expression by Ku Autoantigen or Its Individual Subunits

1996 • 50 citations

A human gene that restores the DNA-repair defect in SCID mice is located on 8p11.1?q11.1

1994 • 37 citations

A DNA double-strand break repair-deficient mutant of CHO cells shows reduced radiosensitization after exposure to hyperthermic temperatures in the plateau phase of growth

1990 • 35 citations

Regulated expression of p150,95 (CD11c/CD18; αX/β2) and VLA‐4 (CD49d/CD29; α4/β1) integrins during myeloid cell differentiation

1994 • 34 citations

DNA damage production in CHO cells at elevated temperatures

1985 • 29 citations

Methylation-associated Transcriptional Silencing of the Major Histocompatibility Complex-linked hsp70 Genes in Mouse Cell Lines

1995 • 20 citations

DNA Lesions in Hyperthermic Cell Killing: Effects of Thermotolerance, Procaine, and Erythritol

1986 • 19 citations

Stable overexpression of human HSF‐1 in murine cells suggests activation rather than expression of HSF‐1 to be the key regulatory step in the heat shock gene expression

1995 • 19 citations

Thermal response and hyperthermic radiosensitization of scid mouse bone marrow CFU-C

1995 • 12 citations

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