Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II.

Characterization of a high molecular weight acidic nuclear protein recognized by autoantibodies in sera from patients with polymyositis-scleroderma overlap.

1981 • 430 citations

Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen.

1990 • 415 citations

Human general transcription factor IIH phosphorylates the C-terminal domain of RNA polymerase II

1992 • 407 citations

A unique structure at the carboxyl terminus of the largest subunit of eukaryotic RNA polymerase II.

1985 • 346 citations

Characterization of the DNA-binding protein antigen Ku recognized by autoantibodies from patients with rheumatic disorders.

1986 • 333 citations

Messenger RNA synthesis in mammalian cells is catalyzed by the phosphorylated form of RNA polymerase II.

1987 • 288 citations

A DNA-activated protein kinase from HeLa cell nuclei.

1990 • 285 citations

Cloning of a human gene encoding the general transcription initiation factor IIB

1991 • 274 citations

HeLa nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA-multimeric protein complex

1989 • 273 citations

Phosphorylation of RNA polymerase by the murine homologue of the cell-cycle control protein cdc2

1989 • 270 citations

Factors involved in specific transcription by mammalian RNA polymerase II: role of transcription factors IIA, IID, and IIB during formation of a transcription-competent complex.

1990 • 255 citations

Intragenic and extragenic suppressors of mutations in the heptapeptide repeat domain of Saccharomyces cerevisiae RNA polymerase II.

1989 • 250 citations

The C-terminal domain of the largest subunit of RNA polymerase II of Saccharomyces cerevisiae, Drosophila melanogaster, and mammals: a conserved structure with an essential function.

1988 • 246 citations

The transition of RNA polymerase II from initiation to elongation is associated with phosphorylation of the carboxyl-terminal domain of subunit IIa

1989 • 236 citations

Inhibition of in Vivo and in Vitro Transcription by Monoclonal Antibodies Prepared against Wheat Germ RNA Polymerase II That React with the Heptapeptide Repeat of Eukaryotic RNA Polymerase II

1989 • 228 citations

Molecular Cloning of cDNA Encoding the p70 (Ku) Lupus Autoantigen

1989 • 212 citations

Genetic analysis of the repetitive carboxyl-terminal domain of the largest subunit of mouse RNA polymerase II.

1988 • 212 citations

Analysis of the mechanism of interaction of simian Ku protein with DNA

1991 • 207 citations

CTD kinase associated with yeast RNA polymerase II initiation factor b

1991 • 199 citations

The C-terminal repeat domain of RNA polymerase II largest subunit is essential in vivo but is not required for accurate transcription initiation in vitro.

1988 • 190 citations

Phosphorylation of RNA polymerase IIA occurs subsequent to interaction with the promoter and before the initiation of transcription.

1990 • 178 citations

The small subunit of transcription factor IIF recruits RNA polymerase II into the preinitiation complex.

1991 • 178 citations

CTD kinase large subunit is encoded by CTK1, a gene required for normal growth of Saccharomyces cerevisiae.

1991 • 170 citations

RNA polymerase II C-terminal repeat influences response to transcriptional enhancer signals

1990 • 163 citations

Use of monoclonal antibodies for the characterization of novel DNA-binding proteins recognized by human autoimmune sera.

1985 • 156 citations

Isolation and characterization of cDNA encoding the 80-kDa subunit protein of the human autoantigen Ku (p70/p80) recognized by autoantibodies from patients with scleroderma-polymyositis overlap syndrome.

1990 • 152 citations

Human Cells Contain a DNA-Activated Protein Kinase that Phosphorylates Simian Virus 40 T Antigen, Mouse p53, and the Human Ku Autoantigen

1990 • 144 citations

Double-stranded DNA induces the phosphorylation of several proteins including the 90 000 mol. wt. heat-shock protein in animal cell extracts.

1985 • 143 citations

Purification and characterization of proximal sequence element-binding protein 1, a transcription activating protein related to Ku and TREF that binds the proximal sequence element of the human U1 promoter.

1990 • 141 citations

DNA binding provides a signal for phosphorylation of the RNA polymerase II heptapeptide repeats.

1992 • 133 citations

An RNA polymerase II transcription factor has an associated DNA-dependent ATPase (dATPase) activity strongly stimulated by the TATA region of promoters.

1989 • 127 citations

cDNA-derived Amino Acid Sequence of the 86-kDa Subunit of the Ku Antigen

1989 • 125 citations

A carboxyl-terminal-domain kinase associated with RNA polymerase II transcription factor delta from rat liver.

1992 • 124 citations

Mutations in RNA polymerase II enhance or suppress mutations in GAL4.

1989 • 123 citations

A protein kinase that phosphorylates the C-terminal repeat domain of the largest subunit of RNA polymerase II.

1989 • 123 citations

Identification of phosphorylation sites in the repetitive carboxyl-terminal domain of the mouse RNA polymerase II largest subunit

1991 • 117 citations

A DNA-Activated Protein Kinase from HeLa Cell Nuclei

1990 • 109 citations

Ku polypeptides synthesized in vitro assemble into complexes which recognize ends of double-stranded DNA.

1992 • 98 citations

A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II

1992 • 98 citations

Transcription-dependent Structural Changes in the C-terminal Domain of Mammalian RNA Polymerase Subunit IIa/o

1989 • 97 citations

Factors Involved in Specific Transcription by Mammalian RNA Polymerase II: Role of Transcription Factors IIA, IID, and IIB during Formation of a Transcription-Competent Complex

1990 • 87 citations

RNA polymerase II carboxy-terminal domain contributes to the response to multiple acidic activators in vitro.

1991 • 85 citations

Phosphorylation causes a conformational change in the carboxyl-terminal domain of the mouse RNA polymerase II largest subunit

1991 • 85 citations

On the mechanisms of ku protein binding to DNA

1992 • 80 citations

Cloning of a Subunit of Yeast RNA Oolymerase II Transcription Factor b and CTD Kinase

1992 • 77 citations

Promoter-dependent phosphorylation of RNA polymerase II by a template-bound kinase. Association with transcriptional initiation

1991 • 73 citations

The C-Terminal Domain of the Largest Subunit of RNA Polymerase II of Saccharomyces cerevisiae, Drosophila melanogaster, and Mammals: a Conserved Structure with an Essential Function

1988 • 72 citations

Mechanism of promoter selection by RNA polymerase II: mammalian transcription factors alpha and beta gamma promote entry of polymerase into the preinitiation complex.

1991 • 70 citations

Promoter-dependent Transcription by RNA Polymerase II Using Immobilized Enzyme Complexes

1989 • 69 citations

Genetic Analysis of the Repetitive Carboxyl-Terminal Domain of the Largest Subunit of Mouse RNA Polymerase II

1988 • 60 citations

Nuclear proteins TREF1 and TREF2 bind to the transcriptional control element of the transferrin receptor gene and appear to be associated as a heterodimer.

1989 • 53 citations

The human U1 snRNA promoter correctly initiates transcription in vitro and is activated by PSE1.

1990 • 51 citations

5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole inhibits a HeLa protein kinase that phosphorylates an RNA polymerase II-derived peptide

1989 • 39 citations

A protein kinase from wheat germ that phosphorylates the largest subunit of RNA polymerase II.

1989 • 37 citations

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