Repression of the Heat Shock Factor 1 Transcriptional Activation Domain Is Modulated by Constitutive Phosphorylation

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Current Protocols in Molecular Biology

1989 • 1,916 citations

[11] Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates

1991 • 1,463 citations

Cells in Stress: Transcriptional Activation of Heat Shock Genes

1993 • 1,429 citations

The regulation of transcription by phosphorylation

1992 • 1,316 citations

The Biology of heat shock proteins and molecular chaperones.

1994 • 1,226 citations

Isolation and Characterization of Full-Length cDNA Clones for Human α-, β-, and γ-Actin mRNAs: Skeletal but Not Cytoplasmic Actins Have an Amino-Terminal Cysteine that Is Subsequently Removed

1983 • 1,220 citations

The biology of heat shock proteins and molecular chaperones

1994 • 1,203 citations

Heat Shock Transcription Factors: Structure and Regulation

1995 • 1,179 citations

Yeast heat shock factor is an essential DNA-binding protein that exhibits temperature-dependent phosphorylation

1988 • 886 citations

Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress.

1993 • 879 citations

Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity.

1994 • 718 citations

Protein traffic on the heat shock promoter: Parking, stalling, and trucking along

1993 • 507 citations

The protein kinase C-activated MAP kinase pathway of Saccharomyces cerevisiae mediates a novel aspect of the heat shock response.

1995 • 498 citations

Regulation of Heat Shock Factor Trimer Formation: Role of a Conserved Leucine Zipper

1993 • 486 citations

Molecular cloning and expression of a human heat shock factor, HSF1.

1991 • 472 citations

Structure and expression of the human gene encoding major heat shock protein HSP70.

1985 • 461 citations

Activation of human heat shock genes is accompanied by oligomerization, modification, and rapid translocation of heat shock transcription factor HSF1.

1993 • 455 citations

Effect of Sodium Salicylate on the Human Heat Shock Response

1992 • 411 citations

Coordinate changes in heat shock element-binding activity and HSP70 gene transcription rates in human cells.

1988 • 407 citations

Signal transduction from the cell surface to the nucleus through the phosphorylation of transcription factors

1994 • 404 citations

Trimerization of a yeast transcriptional activator via a coiled-coil motif

1989 • 392 citations

Sequential Phosphorylation by Mitogen-activated Protein Kinase and Glycogen Synthase Kinase 3 Represses Transcriptional Activation by Heat Shock Factor-1

1996 • 381 citations

Molecular cloning and expression of a hexameric Drosophila heat shock factor subject to negative regulation

1990 • 375 citations

Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines

1995 • 363 citations

Activation of Heat Shock Factor 1 DNA Binding Precedes Stress-induced Serine Phosphorylation

1996 • 294 citations

Activation in vitro of sequence-specific DNA binding by a human regulatory factor

1988 • 278 citations

Characterization of a novel chicken heat shock transcription factor, heat shock factor 3, suggests a new regulatory pathway.

1993 • 264 citations

Multiple Layers of Regulation of Human Heat Shock Transcription Factor 1

1995 • 246 citations

Repression of human heat shock factor 1 activity at control temperature by phosphorylation.

1996 • 231 citations

Activation of Drosophila heat shock factor: conformational change associated with a monomer-to-trimer transition.

1993 • 223 citations

Activation of the DNA-Binding Ability of Human Heat Shock Transcription Factor 1 May Involve the Transition from an Intramolecular to an Intermolecular Triple-Stranded Coiled-Coil Structure

1994 • 198 citations

Attenuation of the heat shock response in HeLa cells is mediated by the release of bound heat shock transcription factor and is modulated by changes in growth and in heat shock temperatures.

1991 • 197 citations

Arachidonate is a potent modulator of human heat shock gene transcription.

1994 • 192 citations

A Heat Shock-Responsive Domain of Human HSF1 That Regulates Transcription Activation Domain Function

1995 • 180 citations

Pharmacological modulation of heat shock factor 1 by antiinflammatory drugs results in protection against stress-induced cellular damage.

1995 • 179 citations

Rapid changes in Drosophila transcription after an instantaneous heat shock.

1993 • 164 citations

The Regulatory Domain of Human Heat Shock Factor 1 Is Sufficient To Sense Heat Stress

1996 • 137 citations

The Carboxyl-Terminal Transactivation Domain of Heat Shock Factor 1 Is Negatively Regulated and Stress Responsive

1995 • 128 citations

A short element required for turning off heat shock transcription factor: evidence that phosphorylation enhances deactivation.

1994 • 123 citations

Regulating transcription factor activity by phosphorylation

1992 • 115 citations

Mouse Heat Shock Transcription Factors 1 and 2 Prefer a Trimeric Binding Site but Interact Differently with the HSP70 Heat Shock Element

1993 • 109 citations

Salicylate Triggers Heat Shock Factor Differently than Heat

1995 • 108 citations

MAP kinase activation during heat shock in quiescent and exponentially growing mammalian cells

1993 • 73 citations

Mitogen-activated protein kinase acts as a negative regulator of the heat shock response in NIH3T3 cells.

1995 • 66 citations

XCL100, an inducible nuclear MAP kinase phosphatase from Xenopus laevis: Its role in MAP kinase inactivation in differentiated cells and its expression during early development

1995 • 42 citations

Activation of mitogen-activated protein kinase by heat shock treatment in Drosophila

1995 • 16 citations

Regulation of Heat Shock Gene Transcription by a Family of Heat Shock Transcription Factors

1994 • 9 citations

Stress causes induction of MAP kinase-specific phosphatase and rapid repression of MAP kinase activity in Drosophila

1995 • 5 citations