Methylation-associated Transcriptional Silencing of the Major Histocompatibility Complex-linked hsp70 Genes in Mouse Cell Lines

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

CpG Islands in vertebrate genomes

1987 • 3,315 citations

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

1985 • 2,145 citations

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

1994 • 1,542 citations

Cells in Stress: Transcriptional Activation of Heat Shock Genes

1993 • 1,429 citations

The 5′ ends of Drosophila heat shock genes in chromatin are hypersensitive to DNase I

1980 • 1,114 citations

Promoter-specific activation of RNA polymerase II transcription by Sp1

1986 • 1,054 citations

In Vivo Footprinting of a Muscle Specific Enhancer by Ligation Mediated PCR

1989 • 972 citations

Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress.

1993 • 879 citations

Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis.

1994 • 840 citations

High levels of De Novo methylation and altered chromatin structure at CpG islands in cell lines

1990 • 709 citations

The RNA polymerase II molecule at the 5′ end of the uninduced hsp70 gene of D. melanogaster is transcriptionally engaged

1988 • 662 citations

Key features of heat shock regulatory elements.

1988 • 566 citations

Two protein-binding sites in chromatin implicated in the activation of heat-shock genes

1984 • 474 citations

Structure and expression of the human gene encoding major heat shock protein HSP70.

1985 • 461 citations

Activation of human heat shock genes is accompanied by oligomerization, modification, and rapid translocation of heat shock transcription factor HSF1.

1993 • 455 citations

Germline Transformation Used to Define Key Features of Heat-Shock Response Elements

1988 • 451 citations

Transcriptional regulation of heat shock genes. A paradigm for inducible genomic responses.

1992 • 417 citations

Coordinate changes in heat shock element-binding activity and HSP70 gene transcription rates in human cells.

1988 • 407 citations

Structure and expression of the three MHC-linked HSP70 genes

1990 • 397 citations

Stress-induced oligomerization and chromosomal relocalization of heat-shock factor

1991 • 391 citations

Cloning and characterization of two mouse heat shock factors with distinct inducible and constitutive DNA-binding ability.

1991 • 381 citations

Human major histocompatibility complex contains genes for the major heat shock protein HSP70.

1989 • 336 citations

Human HSP70 promoter contains at least two distinct regulatory domains.

1986 • 326 citations

Sp1 transcription factor binds DNA and activates transcription even when the binding site is CpG methylated.

1988 • 308 citations

Activation of Heat Shock Factor 2 during Hemin-Induced Differentiation of Human Erythroleukemia Cells

1992 • 281 citations

Facilitated binding of GAL4 and heat shock factor to nucleosomal templates: differential function of DNA-binding domains.

1991 • 269 citations

(CT)n (GA)n repeats and heat shock elements have distinct roles in chromatin structure and transcriptional activation of the Drosophila hsp26 gene.

1993 • 251 citations

In vivo footprint and methylation analysis by PCR-aided genomic sequencing: comparison of active and inactive X chromosomal DNA at the CpG island and promoter of human PGK-1.

1990 • 250 citations

Sequence and regulation of a gene encoding a human 89-kilodalton heat shock protein.

1989 • 241 citations

Heat-Inducible Human Factor That Binds to a Human hsp70 Promoter

1987 • 232 citations

Constitutive binding of yeast heat shock factor to DNA in vivo.

1988 • 221 citations

Cytosine methylation does not affect binding of transcription factor Sp1.

1988 • 201 citations

Graded methylation in the promoter and body of the O6-methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human glioma cells.

1994 • 200 citations

Characterization and sequence of a mouse hsp70 gene and its expression in mouse cell lines

1990 • 187 citations

Identification of multiple HTF-island associated genes in the human major histocompatibility complex class III region.

1989 • 183 citations

Activation of heat shock factor 2 during hemin-induced differentiation of human erythroleukemia cells.

1992 • 168 citations

Heat shock-induced interactions of heat shock transcription factor and the human hsp70 promoter examined by in vivo footprinting.

1991 • 159 citations

CG dinucleotide clusters in MHC genes and in 5′ demethylated genes

1984 • 146 citations

DNA binding of heat shock factor to the heat shock element is insufficient for transcriptional activation in murine erythroleukemia cells.

1990 • 143 citations

Heat-inducible human factor that binds to a human hsp70 promoter.

1987 • 132 citations

Inactive chromatin spreads from a focus of methylation.

1993 • 124 citations

Molecular cloning and analysis of DNA complementary to three mouse Mr = 68,000 heat shock protein mRNAs.

1986 • 116 citations

Methylation-related chromatin structure is associated with exclusion of transcription factors from and suppressed expression of the O-6-methylguanine DNA methyltransferase gene in human glioma cell lines.

1994 • 116 citations

Genomic sequencing reveals a 5-methylcytosine-free domain in active promoters and the spreading of preimposed methylation patterns.

1989 • 109 citations

Progressive de novo DNA methylation at the bcr-abl locus in the course of chronic myelogenous leukemia.

1994 • 104 citations

Nucleosome binding by the constitutive transcription factor Sp1.

1994 • 100 citations

Demethylation of specific sites in the 5' region of the inactive X-linked human phosphoglycerate kinase gene correlates with the appearance of nuclease sensitivity and gene expression.

1988 • 90 citations

Characterization of constitutive HSF2 DNA-binding activity in mouse embryonal carcinoma cells.

1994 • 80 citations

Heat shock-regulated transcription in vitro from a reconstituted chromatin template.

1991 • 80 citations

Differential expression of the homeobox gene Hox-1.3 in F9 embryonal carcinoma cells.

1988 • 72 citations

Deficient induction of human hsp70 heat shock gene transcription in Y79 retinoblastoma cells despite activation of heat shock factor 1.

1994 • 69 citations

Three Hsp70 Genes Are Located in the C4-H-2D Region: Possible Candidates for the Orch-1 Locus

1993 • 61 citations

High-resolution methylation analysis of the human hypoxanthine phosphoribosyltransferase gene 5' region on the active and inactive X chromosomes: correlation with binding sites for transcription factors.

1994 • 58 citations

Lack of class I H-2 antigens in cells transformed by radiation leukemia virus is associated with methylation and rearrangement of H-2 DNA.

1986 • 40 citations

Structure and expression of an inducible HSP70-encoding gene from Mus musculus

1994 • 33 citations

Deficient activation of heat shock gene transcription in embryonal carcinoma cells

1987 • 28 citations

REPRESSION OF CLASS I H‐2K,H‐2D ANTIGENS ON GR9 METHYLCHOLANTHRENE‐INDUCED TUMOUR CELL CLONES IS RELATED TO THE LEVEL OF DNA METHYLATION

1986 • 27 citations

Heat shock factor can activate transcription while bound to nucleosomal DNA in Saccharomyces cerevisiae.

1994 • 23 citations

The major heat-shock protein hsp 68 is not induced by stress in mouse erythroleukemia cell lines

1988 • 23 citations

Decreased stress inducibility of the HSP68 protein in a rat hepatoma variant clone

1992 • 19 citations

Nonexpression of a major heat shock gene in mouse plasmacytoma MPC-11.

1985 • 16 citations

In Vivo Growth of a Murine Lymphoma Cell Line Alters Regulation of Expression of HSP72

1995 • 13 citations