Sequence-specific DNA Binding and Transcription Factor Phosphorylation by Ku Autoantigen/DNA-dependent Protein Kinase

The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen

1993 • 1,219 citations

Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor.

1987 • 999 citations

Functional domains of the human glucocorticoid receptor

1986 • 933 citations

Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation

1995 • 862 citations

DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

1995 • 742 citations

Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination

1994 • 637 citations

DNA-Dependent Kinase (p350) as a Candidate Gene for the Murine SCID Defect

1995 • 610 citations

Absence of p350 Subunit of DNA-Activated Protein Kinase from a Radiosensitive Human Cell Line

1995 • 530 citations

The ability of a ternary complex to form over the serum response element correlates with serum inducibility of the human c-fos promoter

1989 • 495 citations

Ethidium bromide provides a simple tool for identifying genuine DNA-independent protein associations.

1992 • 461 citations

Characterization of a high molecular weight acidic nuclear protein recognized by autoantibodies in sera from patients with polymyositis-scleroderma overlap.

1981 • 430 citations

Transcription Factor Loading on the MMTV Promoter: A Bimodal Mechanism for Promoter Activation

1992 • 411 citations

Independent modes of transcriptional activation by the p50 and p65 subunits of NF-kappa B.

1992 • 373 citations

Restoration of X-ray Resistance and V(D)J Recombination in Mutant Cells by Ku cDNA

1994 • 351 citations

A human RNA polymerase II complex associated with SRB and DNA-repair proteins

1996 • 341 citations

Characterization of the DNA-binding protein antigen Ku recognized by autoantibodies from patients with rheumatic disorders.

1986 • 333 citations

Hormone induces binding of receptors and transcription factors to a rearranged nucleosome on the MMTV promoter in vivo.

1995 • 313 citations

Binding of Ku protein to DNA. Measurement of affinity for ends and demonstration of binding to nicks.

1993 • 311 citations

Functional dissection of the hormone and DNA binding activities of the glucocorticoid receptor.

1987 • 299 citations

A DNA-activated protein kinase from HeLa cell nuclei.

1990 • 285 citations

ATM-related genes: What do they tell us about functions of the human gene?

1995 • 276 citations

HeLa nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA-multimeric protein complex

1989 • 273 citations

Characterization of a Monoclonal Antibody to the Rat Liver Glucocorticoid Receptor*

1984 • 263 citations

EBP-80, a transcription factor closely resembling the human autoantigen Ku, recognizes single- to double-strand transitions in DNA

1993 • 247 citations

Mutations in the glucocorticoid receptor zinc finger region that distinguish interdigitated DNA binding and transcriptional enhancement activities.

1989 • 240 citations

Absence of a Ku-like DNA end binding activity in the xrs double-strand DNA repair-deficient mutant.

1994 • 238 citations

Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen.

1994 • 225 citations

Ubiquitous transcription factor OTF-1 mediates induction of the MMTV promoter through synergistic interaction with hormone receptors

1991 • 224 citations

Involvement of the Ku autoantigen in the cellular response to DNA double-strand breaks.

1994 • 215 citations

Sequence-specific DNA binding by Ku autoantigen and its effects on transcription

1996 • 211 citations

Identification of phosphorylated sites in the mouse glucocorticoid receptor.

1991 • 208 citations

Analysis of the mechanism of interaction of simian Ku protein with DNA

1991 • 207 citations

Identification of three proline-directed phosphorylation sites in the human androgen receptor.

1995 • 174 citations

DNA-dependent protein kinase (Ku protein-p350 complex) assembles on double-stranded DNA.

1994 • 168 citations

Bidirectional transport of glucocorticoid receptors across the nuclear envelope.

1993 • 167 citations

Use of monoclonal antibodies for the characterization of novel DNA-binding proteins recognized by human autoimmune sera.

1985 • 156 citations

Purification and characterization of proximal sequence element-binding protein 1, a transcription activating protein related to Ku and TREF that binds the proximal sequence element of the human U1 promoter.

1990 • 141 citations

DNA-dependent protein kinase is activated by nicks and larger single-stranded gaps

1994 • 139 citations

Complementation of the ionizing radiation sensitivity, DNA end binding, and V(D)J recombination defects of double-strand break repair mutants by the p86 Ku autoantigen.

1995 • 138 citations

A transcriptional repressor of c-myc

1989 • 129 citations

Substrate specificity of a proteolytic enzyme isolated from a mutant of Pseudomonas fragi.

1980 • 122 citations

Influence of a steroid receptor DNA-binding domain on transcriptional regulatory functions.

1994 • 121 citations

DNA-dependent protein kinase: a potent inhibitor of transcription by RNA polymerase I.

1995 • 121 citations

Repair and Recombination: How to make ends meet

1995 • 101 citations

Two Regions of the Mouse Mammary Tumor Virus Long Terminal Repeat Regulate the Activity of Its Promoter in Mammary Cell Lines

1991 • 88 citations

A manual sequencing method for identification of phosphorylated amino acids in phosphopeptides

1991 • 87 citations

Selectivity of Cell Cycle Regulation of Glucocorticoid Receptor Function

1995 • 82 citations

Polyacrylamide gel electrophoresis of small peptides

1984 • 80 citations

The nucleolar transcription activator UBF relieves Ku antigen-mediated repression of mouse ribosomal gene transcription

1993 • 80 citations

Identification of phosphorylation sites unique to the B form of human progesterone receptor. In vitro phosphorylation by casein kinase II.

1994 • 80 citations

Transcriptional repression of a hormone-responsive promoter

1987 • 77 citations

A Constitutive Heat Shock Element-binding Factor Is Immunologically Identical to the Ku Autoantigen

1995 • 75 citations

Purification of the sequence-specific transcription factor CTCBF, involved in the control of human collagen IV genes: subunits with homology to Ku antigen.

1995 • 71 citations

Common sets of nuclear factors binding to the conserved promoter sequence motif of two coordinately regulated ER protein genes,GRP78andGRP94

1991 • 69 citations

Production and characterization of recombinant human Ku antigen

1994 • 69 citations

Stimulation of the DNA-dependent Protein Kinase by RNA Polymerase II Transcriptional Activator Proteins

1995 • 66 citations

DNA-dependent protein kinase specifically represses promoter-directed transcription initiation by RNA polymerase I.

1995 • 63 citations

The long terminal repeat region of the mouse mammary tumour virus contains multiple regulatory elements

1990 • 62 citations

Purification and characterization of Ku-2, an octamer-binding protein related to the autoantigen Ku.

1991 • 62 citations

Chicken progesterone receptor is phosphorylated by a DNA-dependent protein kinase during in vitro transcription assays.

1992 • 60 citations

Assembly of a glucocorticoid receptor complex prior to DNA binding enhances its specific interaction with a glucocorticoid response element

1991 • 58 citations

Phosphorylation and progesterone receptor function

1995 • 49 citations

Cancer Predisposition: Ataxia–telangiectasia at the crossroads

1995 • 48 citations

p70 lupus autoantigen binds the enhancer of the T-cell receptor beta-chain gene.

1993 • 46 citations

A plasmacytoma-specific factor binds the c-myc promoter region.

1987 • 45 citations

Nucleic acid specificity of a vertebrate telomere-binding protein: evidence for G-G base pair recognition at the core-binding site.

1992 • 44 citations

Hormone-induced hyperphosphorylation of specific phosphorylated sites in the mouse glucocorticoid receptor

1995 • 43 citations

Binding of the transcription factor EBP-80 mediates the methylation response of an intracisternal A-particle long terminal repeat promoter.

1991 • 40 citations

Multipartite structure of a negative regulatory element associated with a steroid hormone-inducible promoter.

1991 • 31 citations

Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells.

1993 • 30 citations

Transcription factor phosphorylation by the DNA-dependent protein kinase

1993 • 28 citations

Autoantigen Ku protein is involved in DNA binding proteins which recognize the U5 repressive element of human T‐cell leukemia virus type I long terminal repeat

1994 • 24 citations

Isolation and Characterization of a Protein Fraction That Binds to Enhancer Core Sequences in Intracisternal A-particle Long Terminal Repeats

1989 • 24 citations

A variant binding sequence for transcription factor EBP-80 confers increased promoter activity on a retroviral long terminal repeat.

1990 • 23 citations

Chicken progesterone receptor expressed in Saccharomyces cerevisiae is correctly phosphorylated at all four Ser-Pro phosphorylation sites

1993 • 23 citations

Repression of mouse mammary tumor virus transcription by a transcription factor complex. Binding of individual components to separated DNA strands.

1994 • 19 citations

Transcriptional regulation of the apoAl gene by hepatic nuclear factor 4 in yeast

1994 • 19 citations

The BCL2 major breakpoint region is a sequence- and cell-cycle-specific binding site of the Ku antigen.

1995 • 18 citations

Nuclear Factor Binding to a DNA Sequence Element That Represses MMTV Transcription Induces a Structural Transition and Leads to the Contact of Single-Stranded Binding Proteins with DNA

1995 • 10 citations

Glucocorticoid receptor phosphorylation in v-mos-transformed cells

1995 • 7 citations