Transcriptional Profiling of Estrogen-Regulated Gene Expression via Estrogen Receptor (ER) α or ERβ in Human Osteosarcoma Cells: Distinct and Common Target Genes for These Receptors

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

2001 • 156,143 citations

Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β

1998 • 4,127 citations

Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis*

2000 • 2,226 citations

HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C

1998 • 2,114 citations

Differential Ligand Activation of Estrogen Receptors ERα and ERβ at AP1 Sites

1997 • 1,808 citations

Sex Steroids and the Construction and Conservation of the Adult Skeleton

2002 • 1,688 citations

Cofactor Dynamics and Sufficiency in Estrogen Receptor–Regulated Transcription

2000 • 1,658 citations

Combinatorial Control of Gene Expression by Nuclear Receptors and Coregulators

2002 • 1,449 citations

Evidence of Estrogen Receptors in Normal Human Osteoblast-Like Cells

1988 • 1,246 citations

The Multifaceted Mechanisms of Estradiol and Estrogen Receptor Signaling

2001 • 1,179 citations

Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis

2000 • 1,175 citations

A Unitary Model for Involutional Osteoporosis: Estrogen Deficiency Causes Both Type I and Type II Osteoporosis in Postmenopausal Women and Contributes to Bone Loss in Aging Men

1998 • 1,142 citations

Nongenotropic, Sex-Nonspecific Signaling through the Estrogen or Androgen Receptors

2001 • 1,123 citations

Estrogen receptor interaction with estrogen response elements

2001 • 1,031 citations

Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production

2002 • 908 citations

Profiling of Estrogen Up- and Down-Regulated Gene Expression in Human Breast Cancer Cells: Insights into Gene Networks and Pathways Underlying Estrogenic Control of Proliferation and Cell Phenotype

2003 • 868 citations

Estrogen receptor pathways to AP-1

2000 • 867 citations

Multiple β1 chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells

1990 • 802 citations

Pyrazole Ligands: Structure−Affinity/Activity Relationships and Estrogen Receptor-α-Selective Agonists

2000 • 749 citations

Estrogen Receptor-β Potency-Selective Ligands: Structure−Activity Relationship Studies of Diarylpropionitriles and Their Acetylene and Polar Analogues

2001 • 666 citations

Nongenotropic, Sex-Nonspecific Signaling through the Estrogen or Androgen Receptors Dissociation from Transcriptional Activity

2001 • 661 citations

Rapid actions of plasma membrane estrogen receptors

2001 • 649 citations

Connections and Regulation of the Human Estrogen Receptor

2002 • 570 citations

Differential Gene Regulation by the Two Progesterone Receptor Isoforms in Human Breast Cancer Cells

2002 • 566 citations

Association of DAP12 with Activating CD94/NKG2C NK Cell Receptors

1998 • 528 citations

Sex Steroids and Bone

2002 • 515 citations

Role of Estrogen Receptor Beta in Estrogen Action

2001 • 496 citations

Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits.

1996 • 441 citations

The Small Gtpase, Rap1, Mediates Cd31-Induced Integrin Adhesion

2000 • 419 citations

Transcriptional activation of genes by 17β-estradiol through estrogen receptor-Sp1 interactions

2001 • 414 citations

Ligand-, Cell-, and Estrogen Receptor Subtype (α/β)-dependent Activation at GC-rich (Sp1) Promoter Elements

2000 • 393 citations

Mechanism of Regulation of the Epac Family of cAMP-dependent RapGEFs

2000 • 390 citations

Activation of pS2 gene transcription is a primary response to estrogen in the human breast cancer cell line MCF-7.

1984 • 379 citations

Characterization of the Biological Roles of the Estrogen Receptors, ERα and ERβ, in Estrogen Target Tissuesin Vivothrough the Use of an ERα-Selective Ligand

2002 • 349 citations

The Molecular Pharmacology of SERMs

1999 • 307 citations

Activities of estrogen receptor alpha- and beta-selective ligands at diverse estrogen responsive gene sites mediating transactivation or transrepression

2003 • 306 citations

Differential Expression of Estrogen Receptors α and β mRNA During Differentiation of Human Osteoblast SV-HFO Cells

1997 • 306 citations

Integration of the Non-genomic and Genomic Actions of Estrogen

2002 • 287 citations

Transcription Activation by the Human Estrogen Receptor Subtypeβ (ERβ) Studied with ERβ and ERα Receptor Chimeras¹

1998 • 267 citations

Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids

2003 • 245 citations

The Actions and Interactions of Sex Steroids and Growth Factors/Cytokines on the Skeleton

1999 • 245 citations

PDZK1 and GREB1 are estrogen-regulated genes expressed in hormone-responsive breast cancer.

2000 • 242 citations

The effects of bone morphogenetic protein-2, -4, and -6 on differentiation of rat osteoblast cells in vitro.

1995 • 241 citations

Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids

2003 • 227 citations

Conformational Changes and Coactivator Recruitment by Novel Ligands for Estrogen Receptor-α and Estrogen Receptor-β: Correlations with Biological Character and Distinct Differences among SRC Coactivator Family Members*

2000 • 220 citations

The role of Rap1 in integrin-mediated cell adhesion

2003 • 208 citations

Estrogen receptors: selective ligands, partners, and distinctive pharmacology.

2000 • 204 citations

Gene selection and clustering for time-course and dose–response microarray experiments using order-restricted inference

2003 • 204 citations

Short-Term, High-Dose Parathyroid Hormone-Related Protein as a Skeletal Anabolic Agent for the Treatment of Postmenopausal Osteoporosis

2003 • 189 citations

The connexin43 gene is responsive to oestrogen

1994 • 187 citations

Transcriptional Effects of Estrogen on Neuronal Neurotensin Gene Expression Involve cAMP/Protein Kinase A-Dependent Signaling Mechanisms

1998 • 171 citations

Estrogen receptor isoform‐specific regulation of endogenous gene expression in human osteoblastic cell lines expressing either ERα or ERβ

2003 • 162 citations

Integrin heterodimer and receptor complexity in avian and mammalian cells.

1989 • 156 citations

Estrogen receptors and endocrine diseases: lessons from estrogen receptor knockout mice

2001 • 151 citations

Identification by differential display of alpha 6 integrin as a candidate tumor suppressor gene

1993 • 144 citations

The Sialomucin CD164 (MGC-24v) Is an Adhesive Glycoprotein Expressed by Human Hematopoietic Progenitors and Bone Marrow Stromal Cells That Serves as a Potent Negative Regulator of Hematopoiesis

1998 • 131 citations

Effect of estradiol on the ultrastructure of the MCF7 human breast cancer cells in culture.

1982 • 107 citations

Estrogen Receptor Regulation of the Na+/H+ Exchanger Regulatory Factor*

1999 • 107 citations

Estrogen Receptor-α Is Developmentally Regulated during Osteoblast Differentiation and Contributes to Selective Responsiveness of Gene Expression

1998 • 107 citations

Ectopic endometrial cells express high concentrations of interleukin (IL)-8 in vivo regardless of the menstrual cycle phase and respond to oestradiol by up-regulating IL-1-induced IL-8 expression in vitro

2001 • 104 citations

Elucidation of estrogen receptor function in bone with the use of mouse models

2002 • 101 citations

Identification and Cloning of a Connective Tissue Growth Factor-like cDNA from Human Osteoblasts Encoding a Novel Regulator of Osteoblast Functions

1999 • 100 citations

Global Transcription Profiling of Estrogen Activity: Estrogen Receptor α Regulates Gene Expression in the Kidney

2003 • 99 citations

Bone morphogenetic protein-6 production in human osteoblastic cell lines. Selective regulation by estrogen.

1998 • 95 citations

Estrogen receptor cofactors expression in breast and endometrial human cancer cells

1999 • 95 citations

Molecular Basis for the Subtype Discrimination of the Estrogen Receptor-β-Selective Ligand, Diarylpropionitrile

2003 • 91 citations

Demonstration of estrogen receptor mRNA in bone using in situ reverse-transcriptase polymerase chain reaction

1997 • 80 citations

17β-estradiol, Progesterone, and Dihydrotestosterone Suppress the Growth of Human Melanoma by Inhibiting Interleukin-8 Production

2001 • 76 citations

Estrogen regulation of human osteoblast function is determined by the stage of differentiation and the estrogen receptor isoform

2001 • 75 citations

Requirement of cyclooxygenase-2 expression and prostaglandins for human prostate cancer cell invasion.

2002 • 72 citations

The parathyroid hormone-related protein receptor is expressed in breast cancer bone metastases and promotes autocrine proliferation in breast carcinoma cells

2003 • 71 citations

In Vivo Regulation of Parathyroid Hormone-Related Peptide Messenger Ribonucleic Acid in the Rat Uterus by 17β-Estradiol

1991 • 71 citations

Adenovirus-Mediated Delivery of a Dominant Negative Estrogen Receptor Gene Abrogates Estrogen-Stimulated Gene Expression and Breast Cancer Cell Proliferation

1999 • 62 citations

Regulation of keratin 19 gene expression by estrogen in human breast cancer cells and identification of the estrogen responsive gene region

2000 • 60 citations

PTH-related protein modulates PC-3 prostate cancer cell adhesion and integrin subunit profile

2003 • 55 citations

Dexamethasone regulates IL-1? and TNF-?-induced interleukin-8 production in human bone marrow stromal and osteoblast-like cells

1994 • 49 citations

CD164-A Novel Sialomucin on CD34⁺Cells

2000 • 40 citations

Identification of Selective Estrogen Receptor Modulators by Their Gene Expression Fingerprints

2000 • 39 citations

Identification of Estrogen-Regulated Genes of Potential Importance for the Regulation of Trabecular Bone Mineral Density

2002 • 39 citations

Autotaxin promotes motility via G protein‐coupled phosphoinositide 3‐kinase γ in human melanoma cells

2002 • 38 citations

Cdc42 and Rac1 are necessary for autotaxin‐induced tumor cell motility in A2058 melanoma cells

2002 • 32 citations

Prostatic secretory protein PSP94: gene organization and promoter sequence in Rhesus monkey and human

1991 • 26 citations

WISP-2 is a secreted protein and can be a marker of estrogen exposure in MCF-7 cells

2002 • 23 citations

Local secretion of parathyroid hormone-related protein by an osteoblastic osteosarcoma (UMR 106-01) cell line results in growth inhibition

2002 • 21 citations

Expression of the alpha 6, beta 1 and beta 4 integrin subunits, basement membrane organization and proteolytic capacities in low and high metastatic human colon carcinoma xenografts.

1995 • 6 citations

Analysis of a cis-Acting Element Involved in Regulation by Estrogen of Human Angiotensinogen Gene Expression.

1998 • 2 citations