Estrogen receptors and endocrine diseases: lessons from estrogen receptor knockout mice

Molecular basis of agonism and antagonism in the oestrogen receptor

1997 • 3,285 citations

The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen

1998 • 2,622 citations

Obesity and the Regulation of Energy Balance

2001 • 2,387 citations

Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?

1999 • 1,965 citations

Nuclear Receptor Coregulators: Cellular and Molecular Biology*

1999 • 1,783 citations

Increased adipose tissue in male and female estrogen receptor-α knockout mice

2000 • 1,226 citations

The Multifaceted Mechanisms of Estradiol and Estrogen Receptor Signaling

2001 • 1,179 citations

Effect of single and compound knockouts of estrogen receptors α (ERα) and β (ERβ) on mouse reproductive phenotypes

2000 • 1,026 citations

Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist

1999 • 963 citations

Postnatal Sex Reversal of the Ovaries in Mice Lacking Estrogen Receptors α and β

1999 • 583 citations

Membrane Estrogen Receptor Engagement Activates Endothelial Nitric Oxide Synthase via the PI3-Kinase–Akt Pathway in Human Endothelial Cells

2000 • 558 citations

Estrogen receptor alpha , not beta , is a critical link in estradiol-mediated protection against brain injury

2001 • 539 citations

Estrogen inhibits the vascular injury response in estrogen receptor α-deficient mice

1997 • 499 citations

Estradiol Modulates bcl-2 in Cerebral Ischemia: A Potential Role for Estrogen Receptors

1999 • 453 citations

Hormone Replacement Therapy and Cardiovascular Disease

2001 • 448 citations

Increased cortical bone mineral content but unchanged trabecular bone mineral density in female ERβ–/– mice

1999 • 412 citations

Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice

2000 • 389 citations

Human vascular endothelial cells contain membrane binding sites for estradiol, which mediate rapid intracellular signaling

2000 • 382 citations

Estrogen receptor gene disruption: molecular characterization and experimental and clinical phenotypes.

1996 • 371 citations

Obesity and Disturbed Lipoprotein Profile in Estrogen Receptor-α-Deficient Male Mice

2000 • 327 citations

The Molecular Pharmacology of SERMs

1999 • 307 citations

Estrogen Receptors α and β Are Differentially Expressed in Developing Human Bone¹

2001 • 303 citations

Estrogen Receptor β (ERβ) Messenger Ribonucleic Acid (mRNA) Expression within the Human Forebrain: Distinct Distribution Pattern to ERα mRNA1

2000 • 272 citations

Estradiol Accelerates Reendothelialization in Mouse Carotid Artery Through Estrogen Receptor-α but Not Estrogen Receptor-β

2001 • 261 citations

Differentiation between vasculoprotective and uterotrophic effects of ligands with different binding affinities to estrogen receptors α and β

1999 • 254 citations

Estrogen inhibits the vascular injury response in estrogen receptor β-deficient female mice

1999 • 254 citations

Evidence of the Colocalization of Estrogen Receptor-β mRNA and Estrogen Receptor-α Immunoreactivity in Neurons of the Rat Forebrain

1998 • 247 citations

Rapid Action of 17β-Estradiol on Kainate-Induced Currents in Hippocampal Neurons Lacking Intracellular Estrogen Receptors*

1999 • 233 citations

Estrogens: Trophic and Protective Factors in the Adult Brain

2001 • 232 citations

Estrogen receptor α is a major mediator of 17β-estradiol’s atheroprotective effects on lesion size in Apoe–/– mice

2001 • 209 citations

Estrogen Suppresses Transcription of Lipoprotein Lipase Gene

2000 • 198 citations

17β-Estradiol Stimulates Expression of Osteoprotegerin by a Mouse Stromal Cell Line, ST-2, via Estrogen Receptor-α*

2001 • 193 citations

Engineering of a Mouse for the in Vivo Profiling of Estrogen Receptor Activity

2001 • 176 citations

Localization of Estrogen Receptor β Protein Expression in Adult Human Bone

2001 • 170 citations

Expression and Localization of Estrogen Receptor-β in Murine and Human Bone

1999 • 169 citations

Estradiol Metabolites Inhibit Endothelin Synthesis by an Estrogen Receptor-Independent Mechanism

2001 • 155 citations

Stroke in Estrogen Receptor-α–Deficient Mice

2000 • 144 citations

Novel effects of estradiol and estrogen receptor α and β on cognitive function

2000 • 141 citations

Myocardial ischemia-reperfusion injury in estrogen receptor-α knockout and wild-type mice

2000 • 141 citations

Estrogen-Induced Vasoprotection Is Estrogen Receptor Dependent

2000 • 119 citations

Identification of Estrogen Receptor β RNA in Human Breast and Abdominal Subcutaneous Adipose Tissue

1998 • 111 citations

Clinically Used Estrogens Differentially Inhibit Human Aortic Smooth Muscle Cell Growth and Mitogen-Activated Protein Kinase Activity

2000 • 108 citations

Estrogen Receptor-α Is Developmentally Regulated during Osteoblast Differentiation and Contributes to Selective Responsiveness of Gene Expression

1998 • 107 citations

Lasofoxifene (CP-336,156), a Selective Estrogen Receptor Modulator, Prevents Bone Loss Induced by Aging and Orchidectomy in the Adult Rat

2000 • 106 citations

Raloxifene Acutely Stimulates Nitric Oxide Release from Human Endothelial Cells Via an Activation of Endothelial Nitric Oxide Synthase

2000 • 97 citations

Biologically Active Estrogen Receptor-β: Evidence from in Vivo Autoradiographic Studies with Estrogen Receptor α-Knockout Mice

1999 • 80 citations

4-Hydroxytamoxifen Trans-Represses Nuclear Factor-κB Activity in Human Osteoblastic U2-OS Cells through Estrogen Receptor (ER)α, and Not through ERβ*

2001 • 78 citations

Coumestrol Antagonizes Neuroendocrine Actions of Estrogen via the Estrogen Receptor α

2001 • 78 citations

Immunocytochemical demonstration of oestrogen receptor beta in blood vessels of the female rat

2001 • 74 citations

Tamoxifen Effects on Endothelial Function and Cardiovascular Risk Factors in Men With Advanced Atherosclerosis

2001 • 73 citations

Preliminary evidence for impaired estrogen receptor-α protein expression in osteoblasts and osteocytes from men with idiopathic osteoporosis

2000 • 72 citations

Estradiol Induces Differential Neuronal Phenotypes by Activating Estrogen Receptor α or β¹

2000 • 72 citations

Oestrogen and the cardiovascular system: the good, the bad and the puzzling

2001 • 51 citations

Cardiovascular Effects of Raloxifene Hydrochloride

2001 • 48 citations

Effect of ovarian steroid deficiency on oestrogen receptor ? expression in bone

1999 • 44 citations

Antiestrogens Specifically Up-Regulate Bone Morphogenetic Protein-4 Promoter Activity in Human Osteoblastic Cells

2000 • 44 citations

Impaired Estrogen Sensitivity in Bone by Inhibiting Both Estrogen Receptor α and β Pathways

2000 • 22 citations

Identification of estrogen target genes in human neural cells

2000 • 14 citations

Deleted Work

1955 • 0 citations