Ligand-, Cell-, and Estrogen Receptor Subtype (α/β)-dependent Activation at GC-rich (Sp1) Promoter Elements

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

Cloning of a novel receptor expressed in rat prostate and ovary.

1996 • 4,782 citations

Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors α and β

1997 • 4,422 citations

MOLECULAR MECHANISMS OF ACTION OF STEROID/THYROID RECEPTOR SUPERFAMILY MEMBERS

1994 • 2,875 citations

ERβ: Identification and characterization of a novel human estrogen receptor

1996 • 2,262 citations

Differential Ligand Activation of Estrogen Receptors ERα and ERβ at AP1 Sites

1997 • 1,808 citations

Human Estrogen Receptor β-Gene Structure, Chromosomal Localization, and Expression Pattern1

1997 • 1,098 citations

Nuclear receptor coactivators and corepressors.

1996 • 917 citations

A role for oestrogens in the male reproductive system

1997 • 872 citations

Cloning, Chromosomal Localization, and Functional Analysis of the Murine Estrogen Receptor β

1997 • 862 citations

Differential Response of Estrogen Receptor α and Estrogen Receptor β to Partial Estrogen Agonists/Antagonists

1998 • 776 citations

CDK-Independent Activation of Estrogen Receptor by Cyclin D1

1997 • 698 citations

Estrogen Receptors α and β Form Heterodimers on DNA

1997 • 681 citations

Tamoxifen activation of the estrogen receptor/AP-1 pathway: potential origin for the cell-specific estrogen-like effects of antiestrogens.

1995 • 665 citations

Mouse Estrogen Receptor β Forms Estrogen Response Element-Binding Heterodimers with Estrogen Receptor α

1997 • 610 citations

Cloning and Characterization of Human Estrogen Receptor β Isoforms

1998 • 508 citations

Tripartite steroid hormone receptor pharmacology: interaction with multiple effector sites as a basis for the cell- and promoter-specific action of these hormones.

1996 • 505 citations

Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens.

1995 • 502 citations

Estrogen inhibits the vascular injury response in estrogen receptor α-deficient mice

1997 • 499 citations

Activation of the ovalbumin gene by the estrogen receptor involves the Fos-Jun complex

1990 • 486 citations

A 13 bp palindrome is a functional estrogen responsive element and interacts specifically with estrogen receptor

1988 • 439 citations

Estrogen receptor (ER) modulators each induce distinct conformational changes in ER α and ER β

1999 • 405 citations

Functional Synergy between the Transcription Factor Sp1 and the Estrogen Receptor

1997 • 399 citations

Estrogen regulation of the insulin-like growth factor I gene transcription involves an AP-1 enhancer.

1994 • 390 citations

Peptide Antagonists of the Human Estrogen Receptor

1999 • 372 citations

Purification and Identification of p68 RNA Helicase Acting as a Transcriptional Coactivator Specific for the Activation Function 1 of Human Estrogen Receptor α

1999 • 359 citations

Interaction of Sp1 with the Growth- and Cell Cycle-Regulated Transcription Factor E2F

1996 • 343 citations

Tissue Distribution of Estrogen Receptors Alpha (ER-α) and Beta (ER-β) mRNA in the Midgestational Human Fetus

1997 • 329 citations

Estrogen Receptor-β mRNA Expression in Rat Ovary: Down-Regulation by Gonadotropins

1997 • 312 citations

HTLV-I Tax Protein Stimulation of DNA Binding of bZIP Proteins by Enhancing Dimerization

1993 • 312 citations

Differential Expression of Estrogen Receptors α and β mRNA During Differentiation of Human Osteoblast SV-HFO Cells

1997 • 306 citations

Human Estrogen Receptor β Binds DNA in a Manner Similar to and Dimerizes with Estrogen Receptor α

1997 • 301 citations

Mechanism of estrogen activation of c-myc oncogene expression.

1992 • 300 citations

Cooperation by Sterol Regulatory Element-binding Protein and Sp1 in Sterol Regulation of Low Density Lipoprotein Receptor Gene

1995 • 295 citations

Expression of Estrogen Receptor β in Rat Bone

1997 • 295 citations

The distribution of estrogen receptor-β mRNA in the rat hypothalamus

1996 • 288 citations

Transcription Activation by the Human Estrogen Receptor Subtypeβ (ERβ) Studied with ERβ and ERα Receptor Chimeras¹

1998 • 267 citations

Mechanisms of Transcriptional Activation of bcl-2 Gene Expression by 17β-Estradiol in Breast Cancer Cells

1999 • 253 citations

Characterization of the hormone responsive element involved in the regulation of the progesterone receptor gene.

1991 • 238 citations

Characterization of the Amino-terminal Transcriptional Activation Function of the Human Estrogen Receptor in Animal and Yeast Cells

1995 • 230 citations

Agonistic Effect of Tamoxifen Is Dependent on Cell Type, ERE-Promoter Context, and Estrogen Receptor Subtype: Functional Difference between Estrogen Receptors α and β

1997 • 224 citations

Expression of Estrogen Receptor-β in Human Breast Tumors

1997 • 214 citations

Estrogen-Induced c-fos Protooncogene Expression in MCF-7 Human Breast Cancer Cells: Role of Estrogen Receptor Sp1 Complex Formation*

1998 • 190 citations

Transcriptional Activation of E2F1 Gene Expression by 17β-Estradiol in MCF-7 Cells Is Regulated by NF-Y-Sp1/Estrogen Receptor Interactions

1999 • 174 citations

Estradiol increases and anti-estrogens antagonize the growth factor-induced activator protein-1 activity in MCF7 breast cancer cells without affecting c-fos and c-jun synthesis

1993 • 159 citations

Transcriptional Activities of Estrogen and Glucocorticoid Receptors Are Functionally Integrated at the AP-1 Response Element*

1997 • 158 citations

Molecular mechanisms of antiestrogen action in breast cancer

1994 • 130 citations

Antiestrogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on 17 beta-estradiol-induced pS2 expression.

1994 • 124 citations

Transcriptional Activation of Insulin-Like Growth Factor-Binding Protein-4 by 17β-Estradiol in MCF-7 Cells: Role of Estrogen Receptor-Sp1 Complexes*

1999 • 121 citations

Estrogen-Induced Retinoic Acid Receptor α1 Gene Expression: Role of Estrogen Receptor-Sp1 Complex

1998 • 118 citations

Functional and physical interactions between the estrogen receptor Sp1 and nuclear aryl hydrocarbon receptor complexes

1998 • 116 citations

Textbook of Endocrinology

1956 • 116 citations

Estrogen Receptor β Activates the Human Retinoic Acid Receptorα -1 Promoter in Response to Tamoxifen and Other Estrogen Receptor Antagonists, but Not in Response to Estrogen

1999 • 106 citations

EM-800, a Novel Antiestrogen, Acts as a Pure Antagonist of the Transcriptional Functions of Estrogen Receptors α and β*

1998 • 100 citations

Responses in the brain of estrogen receptor α-disrupted mice

1997 • 100 citations

Estrogen Receptor α and β Expression in Upper Gastrointestinal Tract with Regulation of Trefoil Factor Family 2 mRNA Levels in Ovariectomized Rats

1997 • 84 citations

Estrogen Induces Adenosine Deaminase Gene Expression in MCF-7 Human Breast Cancer Cells: Role of Estrogen Receptor-Sp1 Interactions**This work was supported by the National Institutes of Health (Grant CA-76636), the Welch Foundation, and the Texas Agricultural Experiment Station.

1999 • 82 citations

Ligand-independent activation of the estrogen receptors alpha and beta by mutations of a conserved tyrosine can be abolished by antiestrogens.

1998 • 75 citations

Principles of Pharmacology: Basic Concepts and Clinical Applications

1997 • 29 citations

Estrogen action in target cells: selective requirements for activation of different hormone response elements

1995 • 27 citations