Cdc42 and Rac1 are necessary for autotaxin‐induced tumor cell motility in A2058 melanoma cells
Data up to Jan 2025
Total Citations Per Year
Abstract
References (40)
Rho GTPases and the Actin Cytoskeleton
1998 • 6,129 citations
The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
1992 • 4,454 citations
Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
1995 • 4,387 citations
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
1992 • 3,628 citations
Integrins and Signal Transduction Pathways: the Road Taken
1995 • 3,002 citations
A brain serine/threonine protein kinase activated by Cdc42 and Rac1
1994 • 1,520 citations
Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production
2002 • 908 citations
Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptors.
1980 • 892 citations
[71] Use of eukaryotic expression technology in the functional analysis of cloned genes
1987 • 834 citations
Characterization of Rac and Cdc42 Activation in Chemoattractant-stimulated Human Neutrophils Using a Novel Assay for Active GTPases
1999 • 765 citations
Focal Adhesion Kinase: a regulator of focal adhesion dynamics and cell movement
2000 • 661 citations
Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors.
1995 • 619 citations
Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein.
1992 • 577 citations
Tumor cell autocrine motility factor.
1986 • 539 citations
Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation.
1996 • 514 citations
Integrin signalling and tyrosine phosphorylation: just the FAKs?
1998 • 502 citations
Lysophosphatidic acid: G-protein signalling and cellular responses
1997 • 492 citations
Vascular Endothelial Growth Factor Stimulates Tyrosine Phosphorylation and Recruitment to New Focal Adhesions of Focal Adhesion Kinase and Paxillin in Endothelial Cells
1997 • 477 citations
PAK to the future
1999 • 391 citations
PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia
1998 • 356 citations
Rearrangements of desmosomal and cytoskeletal proteins during the transition from epithelial to fibroblastoid organization in cultured rat bladder carcinoma cells.
1989 • 210 citations
cDNA cloning of the human tumor motility-stimulating protein, autotaxin, reveals a homology with phosphodiesterases.
1994 • 202 citations
Autotaxin (NPP-2), a metastasis-enhancing motogen, is an angiogenic factor.
2001 • 194 citations
Autotaxin (ATX), a potent tumor motogen, augments invasive and metastatic potential of ras-transformed cells
2000 • 188 citations
Subtype-specific differential regulation of Rho family G proteins and cell migration by the Edg family sphingosine-1-phosphate receptors
2002 • 172 citations
Tumor invasion as dysregulated cell motility
2001 • 167 citations
Autotaxin Is an Exoenzyme Possessing 5′-Nucleotide Phosphodiesterase/ATP Pyrophosphatase and ATPase Activities
1997 • 159 citations
The Dbl-related Protein, Lfc, Localizes to Microtubules and Mediates the Activation of Rac Signaling Pathways in Cells
1999 • 153 citations
Rho Family GTPases Regulate VEGF-Stimulated Endothelial Cell Motility
2001 • 137 citations
Y‐27632, an Inhibitor of Rho‐associated Protein Kinase, Suppresses Tumor Cell Invasion via Regulation of Focal Adhesion and Focal Adhesion Kinase
2000 • 98 citations
Stimulation of Tumor Cell Motility Linked to Phosphodiesterase Catalytic Site of Autotaxin
1996 • 91 citations
Distinct Role of Phosphatidylinositol 3-Kinase and Rho Family GTPases in Vav3-induced Cell Transformation, Cell Motility, and Morphological Changes
2002 • 84 citations
Lysophosphatidic acid induces tyrosine phosphorylation and activation of MAP‐kinase and focal adhesion kinase in cultured Swiss 3T3 cells
1993 • 78 citations
Small GTP‐binding Protein, Rho, Both Increased and Decreased Cellular Motility, Activation of Matrix Metalloproteinase 2 and Invasion of Human Osteosarcoma Cells
2001 • 60 citations
NCK and PAK Participate in the Signaling Pathway by Which Vascular Endothelial Growth Factor Stimulates the Assembly of Focal Adhesions
2001 • 59 citations
Regulation of Rac and Cdc42 Pathways by Gi during Lysophosphatidic Acid-induced Cell Spreading
2001 • 56 citations
Differential regulation of the expression of nucleotide pyrophosphatases/phosphodiesterases in rat liver
1999 • 49 citations
Autotaxin promotes motility via G protein‐coupled phosphoinositide 3‐kinase γ in human melanoma cells
2002 • 38 citations
Tumour motility factors.
1988 • 37 citations
Fluoroaluminate stimulates phosphorylation of p130 Cas and Fak and increases attachment and spreading of preosteoblastic MC3T3-E1 cells
2002 • 29 citations