Activities of estrogen receptor alpha- and beta-selective ligands at diverse estrogen responsive gene sites mediating transactivation or transrepression

Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors α and β

1997 • 4,422 citations

Differential Ligand Activation of Estrogen Receptors ERα and ERβ at AP1 Sites

1997 • 1,808 citations

Combinatorial Control of Gene Expression by Nuclear Receptors and Coregulators

2002 • 1,449 citations

The Multifaceted Mechanisms of Estradiol and Estrogen Receptor Signaling

2001 • 1,179 citations

Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors and

1997 • 1,148 citations

Estrogen receptor pathways to AP-1

2000 • 867 citations

Pyrazole Ligands: Structure−Affinity/Activity Relationships and Estrogen Receptor-α-Selective Agonists

2000 • 749 citations

Repression of the Interleukin-6 Promoter by Estrogen Receptor Is Mediated by NF-κB and C/EBPβ

1995 • 692 citations

Estrogen Receptor-β Potency-Selective Ligands: Structure−Activity Relationship Studies of Diarylpropionitriles and Their Acetylene and Polar Analogues

2001 • 666 citations

Role of Estrogen Receptor Beta in Estrogen Action

2001 • 496 citations

Identification of an Estrogen Response Element Activated by Metabolites of 17β-Estradiol and Raloxifene

1996 • 432 citations

Transcriptional activation of genes by 17β-estradiol through estrogen receptor-Sp1 interactions

2001 • 414 citations

Oestrogen receptors – an overview

1999 • 383 citations

The Estrogen Receptor Enhances AP-1 Activity by Two Distinct Mechanisms with Different Requirements for Receptor Transactivation Functions

1999 • 369 citations

Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism

2002 • 351 citations

Characterization of the Biological Roles of the Estrogen Receptors, ERα and ERβ, in Estrogen Target Tissuesin Vivothrough the Use of an ERα-Selective Ligand

2002 • 349 citations

Novel Ligands that Function as Selective Estrogens or Antiestrogens for Estrogen Receptor-α or Estrogen Receptor-β*

1999 • 312 citations

The Molecular Pharmacology of SERMs

1999 • 307 citations

Down-modulation of interleukin-6 gene expression by 17 beta-estradiol in the absence of high affinity DNA binding by the estrogen receptor.

1994 • 307 citations

Estrogen receptor impairs interleukin-6 expression by preventing protein binding on the NF- B site

1997 • 291 citations

17 beta-Estradiol inhibits expression of human interleukin-6 promoter-reporter constructs by a receptor-dependent mechanism.

1994 • 276 citations

Transcription Activation by the Human Estrogen Receptor Subtypeβ (ERβ) Studied with ERβ and ERα Receptor Chimeras¹

1998 • 267 citations

Repression of interleukin-6 gene expression by 17β-estradiol:

1997 • 251 citations

Antagonists Selective for Estrogen Receptor α

2002 • 227 citations

Conformational Changes and Coactivator Recruitment by Novel Ligands for Estrogen Receptor-α and Estrogen Receptor-β: Correlations with Biological Character and Distinct Differences among SRC Coactivator Family Members*

2000 • 220 citations

Ligand-dependent, transcriptionally productive association of the amino- and carboxyl-terminal regions of a steroid hormone nuclear receptor.

1995 • 209 citations

Estrogen receptors: selective ligands, partners, and distinctive pharmacology.

2000 • 204 citations

Differential Interaction of the Methoxychlor Metabolite 2,2-Bis-(p-Hydroxyphenyl)-1,1,1-Trichloroethane with Estrogen Receptors α and β1

1999 • 188 citations

Structure-function analysis of the hormone binding domain of the human estrogen receptor by region-specific mutagenesis and phenotypic screening in yeast.

1993 • 186 citations

Factor recruitment and TIF2/GRIP1 corepressor activity at a collagenase-3 response element that mediates regulation by phorbol esters and hormones

2001 • 168 citations

The Role of CBP in Estrogen Receptor Cross-Talk with Nuclear Factor-κB in HepG2 Cells

2000 • 143 citations

Estrogen Receptors alpha and beeta Two Receptors of a Kind

2000 • 142 citations

Estrogen Receptor Subtype-Selective Ligands: Asymmetric Synthesis and Biological Evaluation of cis- and trans-5,11-Dialkyl- 5,6,11,12-tetrahydrochrysenes

1999 • 137 citations

Estrogen Receptor α and Activating Protein-1 Mediate Estrogen Responsiveness of the Progesterone Receptor Gene in MCF-7 Breast Cancer Cells

2002 • 129 citations

Involvement of CCAAT/enhancer-binding protein and nuclear factor-kappa B binding sites in interleukin-6 promoter inhibition by estrogens.

1996 • 112 citations

Estrogen Receptor Regulation of the Na+/H+ Exchanger Regulatory Factor*

1999 • 107 citations

The Estrogen Receptor Enhances AP-1 Activity by Two Distinct Mechanisms with Different Requirements for Receptor Transactivation Functions

1999 • 105 citations

Mutations in the Estrogen Receptor Ligand Binding Domain Discriminate between Hormone-dependent Transactivation and Transrepression

2000 • 102 citations

Characterization of mechanisms of interleukin-6 gene repression by estrogen receptor

1997 • 94 citations

Molecular Basis for the Subtype Discrimination of the Estrogen Receptor-β-Selective Ligand, Diarylpropionitrile

2003 • 91 citations

Novel Ligands that Function as Selective Estrogens or Antiestrogens for Estrogen Receptor- or Estrogen Receptor-

1999 • 91 citations

Estrogen Response Elements Alter Coactivator Recruitment through Allosteric Modulation of Estrogen Receptor β Conformation

2001 • 77 citations

The role of estrogen response elements in expression of the Xenopus laevis vitellogenin B1 gene.

1992 • 75 citations

Antagonists Selective for Estrogen Receptor

2002 • 73 citations

Transcription Activation by the Human Estrogen Receptor Subtype (ER ) Studied with ER and ER Receptor Chimeras

1998 • 66 citations

Differential Interaction of the Methoxychlor Metabolite 2,2-Bis-(p-Hydroxyphenyl)-1,1,1-Trichloroethane with Estrogen Receptors and

1999 • 60 citations

A-Ring Reduced Metabolites of 19-nor Synthetic Progestins as Subtype Selective Agonists for ERα

2001 • 59 citations

An issue of tissues: divining the split personalities of selective estrogen receptor modulators

2000 • 58 citations

Conformational Changes and Coactivator Recruitment by Novel Ligands for Estrogen Receptor- and Estrogen Receptor- : Correlations with Biological Character and Distinct Differences among SRC Coactivator Family Members

2000 • 54 citations

Estrogen Receptor Inducibility of the Human Na⁺/H⁺Exchanger Regulatory Factor/Ezrin-Radixin-Moesin Binding Protein 50 (NHE-RF/EBP50) Gene Involving Multiple Half-Estrogen Response Elements

2002 • 45 citations

Involvement of CCAAT/enhancer-binding protein and nuclear factor-kappa B binding sites in interleukin-6 promoter inhibition by estrogens

1996 • 40 citations

The role of estrogen response elements in expression of the Xenopus laevis vitellogenin B1 gene

1992 • 36 citations

The Role of CBP in Estrogen Receptor Cross-Talk with Nuclear Factor- B in HepG2 Cells

2000 • 35 citations

Estrogen Receptor Regulation of the Na+/H+ Exchanger Regulatory Factor

1999 • 31 citations

A-Ring Reduced Metabolites of 19-nor Synthetic Progestins as Subtype Selective Agonists for ER

2001 • 21 citations

Cardiovascular Protection by Estrogen: A Hemodynamic Mechanism?

1994 • 20 citations

Women’s Health in Menopause

1994 • 10 citations

DNA Shuffling Method for Generating Estrogen Receptor α and β Chimeras in Yeast

2003 • 9 citations