Rho-related proteins: actin cytoskeleton and cell cycle

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

Signal transduction from the extracellular matrix.

1993 • 1,727 citations

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1994 • 1,520 citations

On the Crawling of Animal Cells

1993 • 1,020 citations

Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion.

1994 • 985 citations

Cytoskeleton—Plasma Membrane Interactions

1992 • 792 citations

Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho.

1994 • 617 citations

Molecular characterization of CDC42, a Saccharomyces cerevisiae gene involved in the development of cell polarity.

1990 • 560 citations

Identification of a Protein that Binds to the SH3 Region of Abl and Is Similar to Bcr and GAP-rho

1992 • 553 citations

Focal adhesion kinase and associated proteins

1994 • 525 citations

Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins

1994 • 518 citations

Signal transduction pathways regulating Rho-mediated stress fibre formation: requirement for a tyrosine kinase.

1994 • 469 citations

Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling

1994 • 439 citations

Function of Ras as a molecular switch in signal transduction.

1992 • 425 citations

Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85.

1994 • 392 citations

Regulation of cytoplasmic division of Xenopus embryo by rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI).

1993 • 363 citations

Involvement of phosphoinositide 3-kinase in insulin- or IGF-1-induced membrane ruffling.

1994 • 360 citations

A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42

1993 • 319 citations

Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product.

1994 • 314 citations

Platelet-derived growth factor modulation of focal adhesion kinase (p125FAK) and paxillin tyrosine phosphorylation in Swiss 3T3 cells. Bell-shaped dose response and cross-talk with bombesin.

1994 • 305 citations

Control of the yeast bud-site assembly GTPase Cdc42. Catalysis of guanine nucleotide exchange by Cdc24 and stimulation of GTPase activity by Bem3.

1994 • 283 citations

Subcellular localization of Cdc42p, a Saccharomyces cerevisiae GTP-binding protein involved in the control of cell polarity.

1993 • 256 citations

Growth site localization of Rho1 small GTP-binding protein and its involvement in bud formation in Saccharomyces cerevisiae.

1994 • 242 citations

rho family GTPase activating proteins p190, bcr and rhoGAP show distinct specificities in vitro and in vivo.

1993 • 236 citations

Regulation and function of the Rho subfamily of small GTPases

1994 • 233 citations

A rho-like protein is involved in the organisation of the contractile ring in dividing sand dollar eggs

1993 • 230 citations

Cdc42p GTPase is involved in controlling polarized cell growth in Schizosaccharomyces pombe.

1994 • 217 citations

ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells.

1993 • 212 citations

Activation of platelet phosphatidylinositide 3-kinase requires the small GTP-binding protein Rho.

1993 • 211 citations

Mutational analysis of CDC42Sc, a Saccharomyces cerevisiae gene that encodes a putative GTP-binding protein involved in the control of cell polarity.

1991 • 204 citations

Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, is expressed preferentially in lymphocytes.

1993 • 192 citations

Membrane ruffling and signal transduction

1994 • 183 citations

A novel functional target for tumor-promoting phorbol esters and lysophosphatidic acid. The p21rac-GTPase activating protein n-chimaerin

1993 • 179 citations

The three faces of profilin

1993 • 179 citations

F-actin capping proteins

1993 • 175 citations

rac p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling in KB cells.

1994 • 171 citations

The ras-Related Gene rhoB Is an Immediate-Early Gene Inducible by v-Fps, Epidermal Growth Factor, and Platelet-Derived Growth Factor in Rat Fibroblasts

1991 • 162 citations

Characterization of rhoGAP. A GTPase-activating protein for rho-related small GTPases.

1994 • 159 citations

Yeast RHO3 and RHO4 ras superfamily genes are necessary for bud growth, and their defect is suppressed by a high dose of bud formation genes CDC42 and BEM1.

1992 • 155 citations

Orientation and three-dimensional organization of actin filaments in dividing cultured cells.

1993 • 141 citations

LPA: a novel lipid mediator with diverse biological actions

1994 • 139 citations

cDNA cloning of a human mRNA preferentially expressed in hematopoietic cells and with homology to a GDP-dissociation inhibitor for the rho GTP-binding proteins.

1993 • 137 citations

Cloning and expression of a human CDC42 GTPase-activating protein reveals a functional SH3-binding domain.

1993 • 123 citations

Ras-related proteins

1993 • 118 citations

The ras-related gene rhoB is an immediate-early gene inducible by v-Fps, epidermal growth factor, and platelet-derived growth factor in rat fibroblasts.

1991 • 115 citations

The yeast actin cytoskeleton

1994 • 114 citations

Growth-regulated expression of rhoG, a new member of the ras homolog gene family.

1992 • 114 citations

Novel human oncogene lbc detected by transfection with distinct homology regions to signal transduction products.

1994 • 108 citations

Germ cell beta-chimaerin, a new GTPase-activating protein for p21rac, is specifically expressed during the acrosomal assembly stage in rat testis.

1993 • 104 citations

Cleavage furrow: timing of emergence of contractile ring actin filaments and establishment of the contractile ring by filament bundling in sea urchin eggs

1994 • 95 citations

How do cells move along surfaces?

1993 • 87 citations

Molecular cloning and characterization of yeast rho GDP dissociation inhibitor.

1994 • 86 citations

Cytokinesis in animal cells

1989 • 69 citations

The human active breakpoint cluster region-related gene encodes a brain protein with homology to guanine nucleotide exchange proteins and GTPase-activating proteins.

1993 • 69 citations

Cloning and characterization of seven novel Dictyostelium discoideum rac-related genes belonging to the rho family of GTPases

1993 • 68 citations

The CDC42 homologue from Caenorhabditis elegans. Complementation of yeast mutation

1993 • 61 citations

rho gene products, botulinum C3 exoenzyme and cell adhesion

1993 • 57 citations

Expression cDNA cloning of a novel oncogene with sequence similarity to regulators of small GTP-binding proteins.

1994 • 56 citations

Microfilaments and membranes

1993 • 53 citations

Regulated production of an influenza virus spliced mRNA mediated by virus-specific products.

1985 • 39 citations

Occurrence of fibers and their association with talin in the cleavage furrows of PtK2 cells

1994 • 39 citations

Transforming and c-fos promoter/enhancer-stimulating activities of a stimulatory GDP/GTP exchange protein for small GTP-binding proteins.

1992 • 34 citations

rho and rho-Related Proteins

1993 • 1 citations