Concerted action of RAS and G proteins in the sexual response pathways of Schizosaccharomyces pombe.

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Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Transformation of intact yeast cells treated with alkali cations

1983 • 7,688 citations

[12] One-step gene disruption in yeast

1983 • 3,302 citations

In yeast, RAS proteins are controlling elements of adenylate cyclase

1985 • 1,142 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method.

1988 • 983 citations

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

1992 • 948 citations

The Primary Structure of MEK, a Protein Kinase that Phosphorylates the ERK Gene Product

1992 • 931 citations

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1975 • 791 citations

Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases

1992 • 714 citations

Complex formation between RAS and RAF and other protein kinases.

1993 • 633 citations

The STE4 and STE18 genes of yeast encode potential β and γ subunits of the mating factor receptor-coupled G protein

1989 • 491 citations

Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein.

1992 • 490 citations

Genetic analysis of yeast RAS1 and RAS2 genes

1984 • 460 citations

FUS3 encodes a cdc2+/CDC28-related kinase required for the transition from mitosis into conjugation

1990 • 437 citations

The yeast SCG1 gene: A Gα-like protein implicated in the a- and α-factor response pathway

1987 • 431 citations

DNA sequence and characterization of the S. cerevisiae gene encoding adenylate cyclase

1985 • 429 citations

Four mating-type genes control sexual differentiation in the fission yeast.

1988 • 388 citations

Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases.

1991 • 369 citations

GPA1, a haploid-specific essential gene, encodes a yeast homolog of mammalian G protein which may be involved in mating factor signal transduction

1987 • 365 citations

Differential activation of yeast adenylate cyclase by wild type and mutant RAS proteins

1985 • 365 citations

Schizosaccharomyces pombe ste11+ encodes a transcription factor with an HMG motif that is a critical regulator of sexual development.

1991 • 352 citations

RAS proteins can induce meiosis in xenopus oocytes

1985 • 341 citations

The yeast α-factor receptor: structural properties deduced from the sequence of theSTE2gene

1985 • 318 citations

A putative protein kinase overcomes pheromone-induced arrest of cell cycling in S. cerevisiae

1989 • 298 citations

Role of a ras homolog in the life cycle of schizosaccharomyces pombe

1986 • 274 citations

Xenopus MAP kinase activator: identification and function as a key intermediate in the phosphorylation cascade.

1992 • 264 citations

Xenopus MAP kinase activator is a serine/threonine/tyrosine kinase activated by threonine phosphorylation.

1992 • 232 citations

Requirement of either of a pair of ras-related genes of Saccharomyces cerevisiae for spore viability

1984 • 228 citations

Studies of Gene Mutation in Saccharomyces

1956 • 226 citations

The ADE2 gene from Saccharomyces cerevisiae: sequence and new vectors

1990 • 221 citations

Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade.

1992 • 219 citations

FUS3 represses CLN1 and CLN2 and in concert with KSS1 promotes signal transduction.

1991 • 211 citations

The ras oncogene product p21 is not a regulatory component of adenylate cyclase

1985 • 210 citations

byr2, a Schizosaccharomyces pombe gene encoding a protein kinase capable of partial suppression of the ras1 mutant phenotype.

1991 • 208 citations

Isolation of a second yeast Saccharomyces cerevisiae gene (GPA2) coding for guanine nucleotide-binding regulatory protein: studies on its structure and possible functions.

1988 • 206 citations

Nucleotide sequence of the yeast regulatory gene STE7 predicts a protein homologous to protein kinases.

1986 • 189 citations

STE11 is a protein kinase required for cell-type-specific transcription and signal transduction in yeast.

1990 • 178 citations

Functional homology of protein kinases required for sexual differentiation in Schizosaccharomyces pombe and Saccharomyces cerevisiae suggests a conserved signal transduction module in eukaryotic organisms.

1993 • 166 citations

Differential activation of p44mapk (ERK1) by α-thrombin and thrombin-receptor peptide agonist

1993 • 163 citations

Characterization of a fission yeast gene, gpa2, that encodes a G alpha subunit involved in the monitoring of nutrition.

1992 • 159 citations

Isolation and characterization of a gene encoding a G-protein alpha subunit from Schizosaccharomyces pombe: involvement in mating and sporulation pathways.

1991 • 156 citations

A gene which encodes a predicted protein kinase can restore some functions of the ras gene in fission yeast.

1988 • 153 citations

Homologous activators of ras in fission and budding yeast

1990 • 142 citations

Involvement of ras in sexual differentiation but not in growth control in fission yeast

1986 • 139 citations

The Schizosaccharomyces pombe mam2 gene encodes a putative pheromone receptor which has a significant homology with the Saccharomyces cerevisiae Ste2 protein.

1991 • 138 citations

Yeast peptide pheromones, a-factor and α-factor, activate a common response mechanism in their target cells

1986 • 137 citations

Oncogenic ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes.

1992 • 134 citations

Schizosaccharomyces pombe map3+ encodes the putative M-factor receptor.

1993 • 111 citations

Role of STE genes in the mating factor signaling pathway mediated by GPA1 in Saccharomyces cerevisiae.

1988 • 107 citations

Induction of the yeast α-specific STE3 gene by the peptide pheromone a-factor

1984 • 97 citations

The ras1 function of Schizosaccharomyces pombe mediates pheromone-induced transcription.

1992 • 92 citations

Yeast STE7, STE11, and STE12 genes are required for expression of cell-type-specific genes.

1988 • 92 citations

Multiple regulation of STE2, a mating-type-specific gene of Saccharomyces cerevisiae.

1986 • 88 citations

Homology between the ran1+ gene of fission yeast and protein kinases.

1986 • 85 citations

Bombesin and epidermal growth factor stimulate the mitogen-activated protein kinase through different pathways in Swiss 3T3 cells

1993 • 81 citations

Schizosaccharomyces pombe ras1 and byr1 are functionally related genes of the ste family that affect starvation-induced transcription of mating-type genes.

1990 • 79 citations

sar1, a gene from Schizosaccharomyces pombe encoding a protein that regulates ras1.

1991 • 77 citations

A requirement for Ras protein function in thrombin-stimulated mitogenesis in astrocytoma cells.

1993 • 71 citations

Chromosomal context dependence of a eukaryotic recombinational hot spot.

1992 • 61 citations

A gene encoding a protein with seven zinc finger domains acts on the sexual differentiation pathways of Schizosaccharomyces pombe.

1992 • 44 citations

A gene fromS. pombewith homology toE. coliRNAse III blocks conjugation and sporulation when overexpressed in wild type cells

1990 • 37 citations

Biological activity of the mammalian RAP genes in yeast.

1990 • 27 citations