Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-Cellulose

1972 • 6,922 citations

Organization and Expression of Eucaryotic Split Genes Coding for Proteins

1981 • 4,730 citations

A simple and very efficient method for generating cDNA libraries

1983 • 4,606 citations

A New Consistent Chromosomal Abnormality in Chronic Myelogenous Leukaemia identified by Quinacrine Fluorescence and Giemsa Staining

1973 • 4,217 citations

Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing

1980 • 3,476 citations

Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome

1975 • 2,865 citations

Purification of Mouse Immunoglobulin Heavy‐Chain Messenger RNAs from Total Myeloma Tumor RNA

1980 • 2,696 citations

A minute chromosome in human chronic granulocytic leukemia

1960 • 2,329 citations

Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome

1975 • 2,228 citations

Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

1985 • 1,650 citations

Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

1984 • 1,644 citations

A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia

1982 • 1,385 citations

Electrophoretic Separations of Large DNA Molecules by Periodic Inversion of the Electric Field

1986 • 920 citations

Structural organization of the bcr gene and its role in the Ph′ translocation

1985 • 920 citations

An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity

1984 • 913 citations

Localization of the c-abl oncogene adjacent to a translocation break point in chronic myelocytic leukaemia

1983 • 848 citations

The Chronic Myelogenous Leukemia-Specific P210 Protein Is the Product of the bcr / abl Hybrid Gene

1986 • 820 citations

Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene

1986 • 489 citations

A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukaemia positive acute lymphoblastic leukaemia

1987 • 448 citations

Unique Forms of the abl Tyrosine Kinase Distinguish Ph ¹ -Positive CML from Ph ¹ -Positive ALL

1987 • 344 citations

Chromosomal abnormalities identify high-risk and low-risk patients with acute lymphoblastic leukemia

1986 • 308 citations

Cell lines and clinical isolates derived from Ph1-positive chronic myelogenous leukemia patients express c-abl proteins with a common structural alteration.

1985 • 282 citations

A novel c-abl protein product in Philadelphia-positive acute lymphoblastic leukaemia

1987 • 278 citations

The chromosomes and causation of human cancer and leukemia.

1966 • 272 citations

Detection of c-abl tyrosine kinase activity in vitro permits direct comparison of normal and altered abl gene products.

1985 • 266 citations

Characterization of a leukemic cell line of the pre‐B phenotype

1979 • 257 citations

Evidence of a New Chimericbcr/c-ablmRNA in Patients with Chronic Myelocytic Leukemia and the Philadelphia Chromosome

1985 • 253 citations

Chronic myelogenous leukemia: recent advances

1985 • 247 citations

Chronic Myelogenous Leukemia — New Concepts

1981 • 245 citations

The Chronic Myelocytic Cell Line K562 Contains a Breakpoint in bcr and Produces a Chimeric bcr/c-abl Transcript

1986 • 192 citations

Chronic myelogenous leukemia: recent advances

1985 • 190 citations

bcr rearrangement and translocation of the c-abl oncogene in Philadelphia positive acute lymphoblastic leukemia

1986 • 186 citations

Heterogeneity of chromosome 22 breakpoint in Philadelphia-positive (Ph+) acute lymphocytic leukemia.

1986 • 160 citations

Ph¹‐POSITIVE ACUTE LEUKAEMIA AND CHRONIC GRANULOCYTIC LEUKAEMIA: ONE OR TWO DISEASES?

1979 • 142 citations

Overlapping cDNA clones define the complete coding region for the P210c-abl gene product associated with chronic myelogenous leukemia cells containing the Philadelphia chromosome.

1986 • 138 citations

Brief Report: Philadelphia Chromosome in Acute Lymphocytic Leukemia

1970 • 133 citations

The chronic myelocytic cell line K562 contains a breakpoint in bcr and produces a chimeric bcr/c-abl transcript.

1986 • 128 citations

Immunoglobulin gene organisation and expression in haemopoietic stem cell leukaemia.

1983 • 112 citations

cDNA sequence for human bcr, the gene that translocates to the abl oncogene in chronic myeloid leukaemia.

1987 • 107 citations

Philadelphia chromosome positive childhood acute lymphoblastic leukemia

1980 • 102 citations

bcr-abl RNA in patients with chronic myelogenous leukemia

1987 • 99 citations

Molecular analysis of both translocation products of a Philadelphia-positive CML patient

1986 • 78 citations

Chronic Granulocytic Leukaemia.

1982 • 69 citations

Comparative analysis of membrane phenotypes in acute lymphoid leukemia and in lymphoid blast crisis of chronic myeloid leukaemia

1977 • 67 citations

Chronic Myelogenous Leukemia — New Concepts

1981 • 63 citations

Variable breakpoints on the Philadelphia chromosome in chronic myelogenous leukemia

1985 • 58 citations

Chromosomes and causation of human cancer and leukemia. XLII. Ph1-positive ALL: An entity within myeloproliferative disorders?

1980 • 34 citations

Functions of the abl oncogene.

1986 • 32 citations