FOXP3+ regulatory T cells: From suppression of rejection to induction of renal allograft tolerance

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

2001 • 3,260 citations

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

2005 • 2,667 citations

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

2001 • 2,503 citations

Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3

2005 • 2,256 citations

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

2007 • 2,215 citations

The inhibitory cytokine IL-35 contributes to regulatory T-cell function

2007 • 1,886 citations

Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β

2001 • 1,609 citations

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

1998 • 1,579 citations

Regulatory T cells in transplantation tolerance

2003 • 1,323 citations

Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

2010 • 1,278 citations

Interleukin‐10‐secreting type 1 regulatory T cells in rodents and humans

2006 • 1,156 citations

Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells

2005 • 1,090 citations

Natural and Adaptive Foxp3+ Regulatory T Cells: More of the Same or a Division of Labor?

2009 • 1,026 citations

Mechanisms of suppression by suppressor T cells

2005 • 1,023 citations

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3

2005 • 957 citations

Cutting Edge: Contact-Mediated Suppression by CD4+CD25+ Regulatory Cells Involves a Granzyme B-Dependent, Perforin-Independent Mechanism

2005 • 870 citations

Induction and mechanism of action of transforming growth factor‐β‐secreting Th3 regulatory cells

2001 • 856 citations

Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production

2007 • 836 citations

Costimulation Blockade with Belatacept in Renal Transplantation

2005 • 833 citations

IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells

2007 • 775 citations

CD25+CD4+ Regulatory T Cells Prevent Graft Rejection: CTLA-4- and IL-10-Dependent Immunoregulation of Alloresponses

2002 • 766 citations

Natural and Induced CD4+CD25+ Cells Educate CD4+CD25− Cells to Develop Suppressive Activity: The Role of IL-2, TGF-β, and IL-10

2004 • 657 citations

Cyclic adenosine monophosphate is a key component of regulatory T cell–mediated suppression

2007 • 618 citations

Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis

2003 • 574 citations

CREB/ATF-dependent T cell receptor–induced FoxP3 gene expression: a role for DNA methylation

2007 • 567 citations

Thymus and Reproduction: Sex-Linked Dysgenesia of the Gonad after Neonatal Thymectomy in Mice

1969 • 554 citations

From Vanilla to 28 Flavors: Multiple Varieties of T Regulatory Cells

2006 • 553 citations

Messenger RNA forFOXP3in the Urine of Renal-Allograft Recipients

2005 • 536 citations

Certified Professionals

2001 • 533 citations

Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells by DNA Methylation

2009 • 528 citations

TGF-β Induces Foxp3 + T-Regulatory Cells from CD4 + CD25 − Precursors

2004 • 527 citations

Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans

2007 • 516 citations

Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production

2006 • 497 citations

An X-linked syndrome of diarrhea, polyendocrinopathy, and fatal infection in infancy

1982 • 436 citations

Regulatory T Cells Sequentially Migrate from Inflamed Tissues to Draining Lymph Nodes to Suppress the Alloimmune Response

2009 • 382 citations

Recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor

2005 • 371 citations

A Novel Mechanism of Action for Anti-Thymocyte Globulin

2006 • 365 citations

Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis

2006 • 359 citations

Epigenetic mechanisms of regulation of Foxp3 expression

2009 • 354 citations

Massive ex Vivo Expansion of Human Natural Regulatory T Cells (T _regs ) with Minimal Loss of in Vivo Functional Activity

2011 • 341 citations

Cutting Edge: Anti-CD25 Monoclonal Antibody Injection Results in the Functional Inactivation, Not Depletion, of CD4+CD25+ T Regulatory Cells

2006 • 333 citations

A Role for CD103 in the Retention of CD4+CD25+ Treg and Control of Leishmania major Infection

2005 • 313 citations

Sequential development of interleukin 2–dependent effector and regulatory T cells in response to endogenous systemic antigen

2005 • 296 citations

IFN-γ production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo

2005 • 292 citations

Control of Autoimmunity by Naturally Arising Regulatory CD4+ T Cells

2003 • 292 citations

Contrasting CD25hiCD4+T Cells/FOXP3 Patterns in Chronic Rejection and Operational Drug-Free Tolerance

2006 • 269 citations

Favorably Tipping the Balance between Cytopathic and Regulatory T Cells to Create Transplantation Tolerance

2003 • 255 citations

Calcineurin Inhibitors, but not Rapamycin, Reduce Percentages of CD4+CD25+FOXP3+ Regulatory T Cells in Renal Transplant Recipients

2006 • 245 citations

Critical role for CCR5 in the function of donor CD4+CD25+ regulatory T cells during acute graft-versus-host disease

2005 • 243 citations

Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3+CD25+CD4+ regulatory T cells

2004 • 240 citations

Transforming growth factor induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis

2005 • 237 citations

A role for the transcription factor Helios in human CD4+CD25+ regulatory T cells

2010 • 226 citations

The Effect of Costimulatory and Interleukin 2 Receptor Blockade on Regulatory T Cells in Renal Transplantation

2008 • 226 citations

Differential Effect of Calcineurin Inhibitors, Anti-CD25 Antibodies and Rapamycin on the Induction of FOXP3 in Human T Cells

2005 • 220 citations

Development and function of CD25+CD4+ regulatory T cells

2004 • 220 citations

Glucocorticoid amplifies IL‐2‐dependent expansion of functional FoxP3⁺CD4⁺CD25⁺ T regulatory cells in vivo and enhances their capacity to suppress EAE

2006 • 218 citations

TGF-β: the missing link in CD4+CD25+ regulatory T cell-mediated immunosuppression

2003 • 207 citations

Alloantigen-Induced CD25+CD4+ Regulatory T Cells Can Develop In Vivo from CD25−CD4+ Precursors in a Thymus-Independent Process

2004 • 201 citations

Costimulatory pathways in transplantation: challenges and new developments

2009 • 192 citations

Thymic regulatory T cells

2005 • 181 citations

CD4+CD25+ Regulatory T Cells Inhibit Experimental Anti-Glomerular Basement Membrane Glomerulonephritis in Mice

2005 • 180 citations

Regulatory T Cells Overexpress a Subset of Th2 Gene Transcripts

2002 • 180 citations

Spontaneous thyroiditis in thymectomized and irradiated Wistar rats.

1973 • 179 citations

CD28 Costimulation Is Essential for Human T Regulatory Expansion and Function

2008 • 160 citations

Pathological and Clinical Correlates of FOXP3+ Cells in Renal Allografts during Acute Rejection

2007 • 158 citations

Presence of FoxP3+ Regulatory T Cells Predicts Outcome of Subclinical Rejection of Renal Allografts

2008 • 154 citations

Regulatory T Cells, Derived from Naïve CD4+CD25− T Cells by In Vitro Foxp3 Gene Transfer, Can Induce Transplantation Tolerance

2005 • 143 citations

FOXP3 Expression in Human Kidney Transplant Biopsies Is Associated with Rejection and Time Post Transplant but Not with Favorable Outcomes

2008 • 125 citations

An update on regulatory T cells in transplant tolerance and rejection

2010 • 122 citations

Specificity of CD4+CD25+ Regulatory T Cell Function in Alloimmunity

2006 • 121 citations

Making sense of regulatory T cell suppressive function

2011 • 113 citations

Reprogrammed FoxP3+ T Regulatory Cells Become IL-17+ Antigen-Specific Autoimmune Effectors In Vitro and In Vivo

2008 • 113 citations

EVIDENCE THAT THE CONTINUED PRESENCE OF THE ORGAN GRAFT AND NOT PERIPHERAL DONOR MICROCHIMERISM IS ESSENTIAL FOR MAINTENANCE OF TOLERANCE TO ALLOANTIGEN IN VIVO IN ANTI-CD4 TREATED RECIPIENTS1,2

1996 • 113 citations

The balance of deletion and regulation in allograft tolerance

2003 • 108 citations

Impact of Immunosuppressive Drugs on CD4+CD25+FOXP3+ Regulatory T Cells: Does In Vitro Evidence Translate to the Clinical Setting?

2008 • 102 citations

Clinical perspectives for regulatory T cells in transplantation tolerance

2011 • 102 citations

A New Type of CD4+ Suppressor T cell Completely Prevents Spontaneous Autoimmune Diabetes and Recurrent Diabetes in Syngeneic Islet-Transplanted NOD Mice

1996 • 96 citations

Everolimus and Basiliximab Permit Suppression by Human CD4+CD25+ Cells in vitro

2005 • 94 citations

Non-invasive diagnosis of acute rejection in kidney transplants with delayed graft function

2008 • 91 citations

Regulatory T Cells in the Control of Transplantation Tolerance and Autoimmunity

2003 • 90 citations

Induction of Foxp3+ regulatory T cells with histone deacetylase inhibitors

2009 • 86 citations

Role and mechanisms of CD4+CD25+ regulatory T cells in the induction and maintenance of transplantation tolerance

2006 • 72 citations

Targeted CTLA-4 Engagement Induces CD4+CD25+CTLA-4high T Regulatory Cells with Target (Allo)antigen Specificity

2004 • 65 citations

Monotherapy rapamycin allows an increase of CD4⁺ CD25^bright+ FoxP3⁺T cells in renal recipients

2009 • 56 citations

Intragraft FOXP3 mRNA Expression Reflects Antidonor Immune Reactivity in Cardiac Allograft Patients

2007 • 55 citations

Clinical Significance of Regulatory T-Cell–Related Gene Expression in Peripheral Blood After Renal Transplantation

2010 • 50 citations

The Regulatory/Cytotoxic Graft-Infiltrating T Cells Differentiate Renal Allograft Borderline Change From Acute Rejection

2007 • 50 citations

Regulatory T Cells in Transplantation

2011 • 42 citations

CD4+CD25+ Regulatory T-Cells Inhibit the Islet Innate Immune Response and Promote Islet Engraftment

2006 • 41 citations

Tumor Recognition and Self-Recognition Induce Distinct Transcriptional Profiles in Antigen-Specific CD4 T Cells

2009 • 36 citations

CD25+Foxp3+ Regulatory T Cells Facilitate CD4+ T Cell Clonal Anergy Induction during the Recovery from Lymphopenia

2006 • 33 citations

Effects of Histone Deacetylase Inhibitor SAHA on Effector and FOXP3+Regulatory T Cells in Rhesus Macaques

2008 • 33 citations

Expression Patterns of Regulatory T-Cell Markers in Accepted and Rejected Nonhuman Primate Kidney Allografts

2007 • 29 citations

Acceptance Reaction

2000 • 29 citations

Is monitoring of FOXP3 Treg cells in renal transplants during acute cellular rejection episodes useful?

2011 • 21 citations

FOXP3+ regulatory T-cells in renal allografts: correlation with long-term graft function and acute rejection.

2011 • 21 citations

The biology and therapeutic potential of natural regulatory T-cells in the bone marrow transplant setting

2008 • 20 citations

Regulatory T Cells in Renal Transplantation and Modulation by Immunosuppression

2009 • 16 citations

Clinical rejection and persistent immune regulation in kidney transplant patients

2009 • 13 citations