Pathological and Clinical Correlates of FOXP3+ Cells in Renal Allografts during Acute Rejection

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

2005 • 2,667 citations

Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β

2001 • 1,609 citations

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

1998 • 1,579 citations

Mechanisms of suppression by suppressor T cells

2005 • 1,023 citations

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3

2005 • 957 citations

Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells

2004 • 805 citations

CD25+CD4+ Regulatory T Cells Prevent Graft Rejection: CTLA-4- and IL-10-Dependent Immunoregulation of Alloresponses

2002 • 766 citations

Natural and Induced CD4+CD25+ Cells Educate CD4+CD25− Cells to Develop Suppressive Activity: The Role of IL-2, TGF-β, and IL-10

2004 • 657 citations

Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level

2005 • 589 citations

Identification of Regulatory T Cells in Tolerated Allografts

2002 • 577 citations

Messenger RNA forFOXP3in the Urine of Renal-Allograft Recipients

2005 • 536 citations

TGF-β Induces Foxp3 + T-Regulatory Cells from CD4 + CD25 − Precursors

2004 • 527 citations

Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production

2006 • 497 citations

Recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor

2005 • 371 citations

A Role for CD103 in the Retention of CD4+CD25+ Treg and Control of Leishmania major Infection

2005 • 313 citations

Sequential development of interleukin 2–dependent effector and regulatory T cells in response to endogenous systemic antigen

2005 • 296 citations

IFN-γ production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo

2005 • 292 citations

Control of Autoimmunity by Naturally Arising Regulatory CD4+ T Cells

2003 • 292 citations

TGF-β Requires CTLA-4 Early after T Cell Activation to Induce FoxP3 and Generate Adaptive CD4+CD25+ Regulatory Cells

2006 • 291 citations

Favorably Tipping the Balance between Cytopathic and Regulatory T Cells to Create Transplantation Tolerance

2003 • 255 citations

Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3+CD25+CD4+ regulatory T cells

2004 • 240 citations

Transforming growth factor induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis

2005 • 237 citations

Autologous stem cell transplantation for autoimmunity induces immunologic self-tolerance by reprogramming autoreactive T cells and restoring the CD4+CD25+ immune regulatory network

2005 • 235 citations

Differential Effect of Calcineurin Inhibitors, Anti-CD25 Antibodies and Rapamycin on the Induction of FOXP3 in Human T Cells

2005 • 220 citations

Development and function of CD25+CD4+ regulatory T cells

2004 • 220 citations

Alloantigen-Induced CD25+CD4+ Regulatory T Cells Can Develop In Vivo from CD25−CD4+ Precursors in a Thymus-Independent Process

2004 • 201 citations

Thymic regulatory T cells

2005 • 181 citations

CD4+CD25+ Regulatory T Cells Inhibit Experimental Anti-Glomerular Basement Membrane Glomerulonephritis in Mice

2005 • 180 citations

Inverse correlation between CD4⁺ regulatory T‐cell population and autoantibody levels in paediatric patients with systemic lupus erythematosus

2006 • 172 citations

Regulatory T Cells, Derived from Naïve CD4+CD25− T Cells by In Vitro Foxp3 Gene Transfer, Can Induce Transplantation Tolerance

2005 • 143 citations

Specificity of CD4+CD25+ Regulatory T Cell Function in Alloimmunity

2006 • 121 citations

The balance of deletion and regulation in allograft tolerance

2003 • 108 citations

A New Type of CD4+ Suppressor T cell Completely Prevents Spontaneous Autoimmune Diabetes and Recurrent Diabetes in Syngeneic Islet-Transplanted NOD Mice

1996 • 96 citations

Regulatory T Cells in the Control of Transplantation Tolerance and Autoimmunity

2003 • 90 citations

Systemic Transforming Growth Factor-??1 Gene Therapy Induces Foxp3+ Regulatory Cells, Restores Self-Tolerance, and Facilitates Regeneration Of Beta Cell Function in Overtly Diabetic Nonobese Diabetic Mice

2005 • 83 citations

Targeted CTLA-4 Engagement Induces CD4+CD25+CTLA-4high T Regulatory Cells with Target (Allo)antigen Specificity

2004 • 65 citations

CD4+CD25+ CELLS REGULATE CD8 CELL ANERGY IN NEONATAL TOLERANT MICE1,2

1999 • 55 citations

Thrombin stimulates proinflammatory and proliferative responses in primary cultures of human proximal tubule cells

2005 • 42 citations

The Role of Regulatory Cells in Miniature Swine Rendered Tolerant to Cardiac Allografts by Donor Kidney Cotransplantation

2003 • 32 citations

Acceptance Reaction

2000 • 29 citations

INDUCTION OF DONOR-SPECIFIC CELLULAR HYPORESPONSE IS FEASIBLE AFTER RENAL TRANSPLANTATION BY A CALCINEURIN-INHIBITOR AND STEROID-FREE IMMUNOSUPPRESSIVE PROTOCOL.

2006 • 2 citations

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