Targeted CTLA-4 Engagement Induces CD4+CD25+CTLA-4high T Regulatory Cells with Target (Allo)antigen Specificity

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

CD4+CD25+ suppressor T cells: more questions than answers

2002 • 2,202 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.

1995 • 2,090 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β

2001 • 1,609 citations

Immunologic tolerance maintained by CD25⁺ CD4⁺ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

2001 • 1,515 citations

CD4+CD25+ Immunoregulatory T Cells

2002 • 1,434 citations

Natural versus adaptive regulatory T cells

2003 • 1,363 citations

CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells.

1996 • 917 citations

IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In Vivo

2001 • 799 citations

CTLA-4 ligation blocks CD28-dependent T cell activation.

1996 • 787 citations

CD4+CD25+ TR Cells Suppress Innate Immune Pathology Through Cytokine-dependent Mechanisms

2003 • 748 citations

Induction of Peripheral T Cell Tolerance In Vivo Requires CTLA-4 Engagement

1997 • 736 citations

Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells

2003 • 674 citations

Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation.

1993 • 569 citations

A Role for TGF-β in the Generation and Expansion of CD4+CD25+ Regulatory T Cells from Human Peripheral Blood

2001 • 540 citations

Generation Ex Vivo of TGF-β-Producing Regulatory T Cells from CD4+CD25− Precursors

2002 • 461 citations

On the fragmentation of monoclonal IgG1, IgG2a, and IgG2b from BALB/c mice.

1983 • 417 citations

Engagement of Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Induces Transforming Growth Factor β (TGF-β) Production by Murine CD4+ T Cells

1998 • 359 citations

Cutting Edge: Depletion of CD4+CD25+ Regulatory T Cells Is Necessary, But Not Sufficient, for Induction of Organ-Specific Autoimmune Disease

2002 • 332 citations

CD4+CD25+ Regulatory T Cells Cure Murine Colitis: The Role of IL-10, TGF-β, and CTLA4

2003 • 301 citations

T cell anergy and costimulation

2003 • 299 citations

CTLA-4 (CD152) Can Inhibit T Cell Activation by Two Different Mechanisms Depending on Its Level of Cell Surface Expression

2000 • 259 citations

CD4+ CD25+ Regulatory T Cells Control T Helper Cell Type 1 Responses to Foreign Antigens Induced by Mature Dendritic Cells In Vivo

2003 • 230 citations

Alloantigen-Induced CD25+CD4+ Regulatory T Cells Can Develop In Vivo from CD25−CD4+ Precursors in a Thymus-Independent Process

2004 • 201 citations

The role of the combination of IL-2 and TGF-β or IL-10 in the generation and function of CD4+ CD25+ and CD8+regulatory T cell subsets

2003 • 188 citations

IL-10 and TGF- induce alloreactive CD4+CD25- T cells to acquire regulatory cell function

2003 • 185 citations

The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens

2003 • 177 citations

Signaling through CD28 and CTLA-4 controls two distinct forms of T cell anergy

2001 • 174 citations

CD28 ligation in T-cell activation: evidence for two signal transduction pathways

1990 • 173 citations

The Roles of CD28 and CD40 Ligand in T Cell Activation and Tolerance

2000 • 172 citations

A Comparative Study between T Regulatory Type 1 and CD4+CD25+ T Cells in the Control of Inflammation

2003 • 153 citations

Cutting edge: blockade of the CD28/B7 costimulatory pathway inhibits intestinal allograft rejection mediated by CD4+ but not CD8+ T cells.

1999 • 143 citations

Mature mainstream TCR alpha beta+CD4+ thymocytes expressing L-selectin mediate "active tolerance" in the nonobese diabetic mouse.

1998 • 134 citations

Cutting Edge: Blockade of the CD28/B7 Costimulatory Pathway Inhibits Intestinal Allograft Rejection Mediated by CD4+ But Not CD8+ T Cells

1999 • 125 citations

Mature Mainstream TCRαβ+CD4+ Thymocytes Expressing L-Selectin Mediate “Active Tolerance” in the Nonobese Diabetic Mouse

1998 • 103 citations

Selective Induction of Dendritic Cells Using Granulocyte Macrophage-Colony Stimulating Factor, But Not fms-Like Tyrosine Kinase Receptor 3-Ligand, Activates Thyroglobulin-Specific CD4+/CD25+ T Cells and Suppresses Experimental Autoimmune Thyroiditis

2003 • 103 citations

Suppression of CD4+ T Lymphocyte Effector Functions by CD4+CD25+ Cells In Vivo

2004 • 99 citations

Induction of Experimental Autoimmune Graves’ Disease in BALB/c Mice

1999 • 98 citations

CTLA4Ig PROLONGS ALLOGRAFT SURVIVAL WHILE SUPPRESSING CELL-MEDIATED IMMUNITY

1994 • 94 citations

CTLA4Ig PROLONGS ALLOGRAFT SURVIVAL WHILE SUPPRESSING CELL-MEDIATED IMMUNITY

1994 • 88 citations

Blockade of T Cell Activation Using a Surface-Linked Single-Chain Antibody to CTLA-4 (CD152)

2000 • 73 citations

Control of organ-specific autoimmunity by immunoregulatory CD4+CD25+ T cells

2001 • 66 citations

B7-blocking agents, alone or in combination with cyclosporin A, induce antigen-specific anergy of human memory T cells.

1997 • 53 citations

Long-term acceptance of composite tissue allografts through mixed chimerism and CD28 blockade

2003 • 49 citations

Targeted engagement of CTLA-4 prevents autoimmune thyroiditis

2003 • 48 citations

Importance of IL-10 for CTLA-4-Mediated Inhibition of Tumor-Eradicating Immunity

2004 • 47 citations

Cutting Edge: Targeted Ligation of CTLA-4 In Vivo by Membrane-Bound Anti-CTLA-4 Antibody Prevents Rejection of Allogeneic Cells

2002 • 47 citations

Generation and characterization of monoclonal antibodies to the human thyrotropin (TSH) receptor: antibodies can bind to discrete conformational or linear epitopes and block TSH binding.

1995 • 40 citations

Active suppression of allogeneic proliferative responses by dendritic cells after induction of long-term allograft survival by CTLA4Ig

2003 • 36 citations

Prevention of Acute Lung Allograft Rejection in Rat by CTLA4Ig

2002 • 28 citations

CD28 ligation in T-cell activation: evidence for two signal transduction pathways

1990 • 21 citations

Targeted Delivery of Anti-CTLA-4 Antibody Downregulates T Cell Function in Vitro and in Vivo

2001 • 16 citations

CTLA-4Ig in Combination with Anti-CD40L Prolongs Xenograft Survival and Inhibits Anti-Gal Ab Production in GT-Ko Mice

2002 • 16 citations