The virological and clinical significance of mutations in the overlapping envelope and polymerase genes of hepatitis B virus

A One-Year Trial of Lamivudine for Chronic Hepatitis B

1998 • 1,779 citations

Viral hepatitis B

2003 • 1,771 citations

RNA VIRUS MUTATIONS AND FITNESS FOR SURVIVAL

1997 • 1,501 citations

Hepatitis B virus.The major etiology of hepatocellular carcinoma

1988 • 1,308 citations

Hepatitis B Vaccine

1980 • 1,107 citations

Vaccine-induced escape mutant of hepatitis B virus

1990 • 1,081 citations

Synthesis and assembly of hepatitis B virus surface antigen particles in yeast

1982 • 854 citations

Identification and characterization of mutations in hepatitis B virus resistant to lamivudine

1998 • 808 citations

Acute exacerbation and hepatitis B virus clearance after emergence of YMDD motif mutation during lamivudine therapy

1999 • 516 citations

Prophylaxis against hepatitis B recurrence following liver transplantation using combination lamivudine and hepatitis B immune globulin

1998 • 494 citations

Efficacy of lamivudine in patients with hepatitis B e antigen-negative/hepatitis B virus DNA-positive (precore mutant) chronic hepatitis befficacy of lamivudine in patients with hepatitis B e antigen-negative/hepatitis B virus DNA-positive (precore mutant) chronic hepatitis befficacy of lamivudine in patients with hepatitis B e antigen-negative/hepatitis B virus DNA-positive (precore mutant) chronic hepatitis befficacy of lamivudine in patients with hepatitis B e antigen-negative/hepatitis B …

1999 • 481 citations

Reduced replication of 3TC-resistant HIV-1 variants in primary cells due to a processivity defect of the reverse transcriptase enzyme.

1996 • 414 citations

Nomenclature for antiviral-resistant human hepatitis B virus mutations in the polymerase region

2001 • 388 citations

Hepatitis B virus mutants associated with 3TC and famciclovir administration are replication defective

1998 • 374 citations

Increased fitness of drug resistant HIV-1 protease as a result of acquisition of compensatory mutations during suboptimal therapy

1999 • 372 citations

Long-Term Therapy of Chronic Hepatitis B With Lamivudine

2000 • 355 citations

Hepatitis B e Antigen Seroconversion After Lamivudine Therapy Is Not Durable in Patients With Chronic Hepatitis B in Korea

2000 • 343 citations

The clinical significance of surface antigen variants of hepatitis B virus

1997 • 326 citations

Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with β-branched amino acids

1999 • 303 citations

Molecular Modeling and Biochemical Characterization Reveal the Mechanism of Hepatitis B Virus Polymerase Resistance to Lamivudine (3TC) and Emtricitabine (FTC)

2001 • 277 citations

Changes of hepatitis B surface antigen variants in carrier children before and after universal vaccination in taiwan

1999 • 259 citations

Yeast-recombinant hepatitis B vaccine. Efficacy with hepatitis B immune globulin in prevention of perinatal hepatitis B virus transmission

1987 • 231 citations

Clearance of the original hepatitis B virus YMDD-motif mutants with emergence of distinct lamivudine-resistant mutants during prolonged lamivudine therapy

2000 • 220 citations

Loss of the common "A" determinant of hepatitis B surface antigen by a vaccine-induced escape mutant.

1992 • 211 citations

Molecular epidemiology of hepatitis B virus vaccine variants in Singapore

1995 • 209 citations

Fulminant reactivation of hepatitis B due to envelope protein mutant that escaped detection by monoclonal HBsAg ELISA

1995 • 208 citations

Reduced Antigenicity of the Hepatitis B Virus HBsAg Protein Arising as a Consequence of Sequence Changes in the Overlapping Polymerase Gene That Are Selected by Lamivudine Therapy

2002 • 203 citations

Evolution of Hepatitis B Virus Polymerase Gene Mutations in Hepatitis B E Antigen-Negative Patients Receiving Lamivudine Therapy

2000 • 203 citations

Selection of hepatitis B virus polymerase mutants with enhanced replication by lamivudine treatment after liver transplantation

2002 • 194 citations

Hepatitis B Virus Envelope Variation After Transplantation With and Without Hepatitis B Immune Globulin Prophylaxis

1996 • 189 citations

YMDD motif in hepatitis B virus DNA polymerase influences on replication and lamivudine resistance: A study byin vitrofull-length viral DNA transfection

1999 • 162 citations

A prospective study on the development of hepatocellular carcinoma from liver cirrhosis with persistent hepatitis B virus infection

1980 • 148 citations

Production and immunological analysis of recombinant hepatitis B vaccine

1986 • 146 citations

Expression of hepatitis B virus surface antigen in yeast

1983 • 138 citations

Susceptibility of lamivudine-resistant hepatitis B virus to other reverse transcriptase inhibitors

1999 • 135 citations

Discontinuous epitopes of hepatitis B surface antigen derived from a filamentous phage peptide library.

1996 • 134 citations

Restoration of Replication Phenotype of Lamivudine-Resistant Hepatitis B Virus Mutants by Compensatory Changes in the “Fingers” Subdomain of the Viral Polymerase Selected as a Consequence of Mutations in the Overlapping S Gene

2002 • 133 citations

A novel hepatitis B virus variant in the sera of immunized children

1994 • 130 citations

Multiple Drug Resistance to Nucleoside Analogues and Nonnucleoside Reverse Transcriptase Inhibitors in an Efficiently Replicating Human Immunodeficiency Virus Type 1 Patient Strain

1996 • 128 citations

Mutational pattern of hepatitis B virus on sequential therapy with famciclovir and lamivudine in patients with hepatitis B virus reinfection occurring under hbig immunoglobulin after liver transplantation

1999 • 127 citations

Yeast recombinant hepatitis B vaccine

1987 • 121 citations

Identification and transmission of hepatitis B virus-related variants.

1986 • 99 citations

Attenuated replication of human immunodeficiency virus type 1 with a didanosine-selected reverse transcriptase mutation

1997 • 97 citations

Persistent Infection of Humans with Hepatitis B Virus: Mechanisms and Consequences

1982 • 94 citations

Sarafianos, S.G. et al. Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with -branched amino acids. Proc. Natl. Acad. Sci. USA 96, 10027-10032

1999 • 92 citations

Antigenic structure of hepatitis B surface antigen: identification of the "d" subtype determinant by chemical modification and use of monoclonal antibodies.

1984 • 88 citations

HBsAG POSITIVE REACTIVITY IN MAN NOT DUE TO HEPATITIS B VIRUS

1987 • 88 citations

Mutational Analysis of the Fingers and Palm Subdomains of Human Immunodeficiency Virus Type-1 (HIV-1) Reverse Transcriptase

1994 • 82 citations

Infant and adolescent hepatitis B immunization up to 1999: a global overview

2000 • 60 citations

Analysis of mutations at positions 115 and 116 in the dNTP binding site of HIV-1 reverse transcriptase

2000 • 57 citations

The K65R Mutation Confers Increased DNA Polymerase Processivity to HIV-1 Reverse Transcriptase

1996 • 55 citations

Increased polymerase fidelity of E89G, a nucleoside analog-resistant variant of human immunodeficiency virus type 1 reverse transcriptase

1996 • 54 citations

Immunological properties of recombinant HBsAg produced in yeast.

1987 • 49 citations

Functional analysis of mutations conferring lamivudine resistance on hepatitis B virus.

1999 • 45 citations

Predictions of the emergence of vaccine-resistant hepatitis B in The Gambia using a mathematical model

2000 • 39 citations

Failure of preexisting antibody against hepatitis B surface antigen to prevent subsequent hepatitis B infection

1983 • 26 citations

Hepatitis B surface antigen (HBsAg) subtype‐specific antibodies in persons vaccinated against hepatitis B

1984 • 22 citations

Prolonged Immunity After Late Booster Doses of Hepatitis B Vaccine

1988 • 22 citations

Mutational Analysis of HBsAg Assembly

1995 • 15 citations

Deleted Work

1955 • 0 citations