Non-sequencing molecular approaches to identify preS2-defective hepatitis B virus variants proved to be associated with severe liver diseases

Hepatitis B Virus Immunopathogenesis

1995 • 1,568 citations

Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice

1989 • 692 citations

The role of envelope proteins in hepatitis B virus assembly.

1991 • 389 citations

Structural and pathological effects of synthesis of hepatitis B virus large envelope polypeptide in transgenic mice.

1987 • 353 citations

Clinical relevance of hepatitis B viral mutations

2000 • 348 citations

Hepadnavirus envelope proteins regulate covalently closed circular DNA amplification

1990 • 332 citations

Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice

1986 • 264 citations

Inhibition of Secretion of Hepatitis B Surface Antigen by a Related Presurface Polypeptide

1986 • 211 citations

Prevalence and significance of hepatitis B virus (HBV) pre-S mutants in serum and liver at different replicative stages of chronic HBV infection

2001 • 203 citations

Expression of hepatitis B virus surface and core antigens: influences of pre-S and precore sequences

1987 • 165 citations

Emergence of and takeover by hepatitis B virus (HBV) with rearrangements in the pre-S/S and pre-C/C genes during chronic HBV infection

1991 • 146 citations

Infectious Hepatitis B Virus Variant Defective in Pre-S2 Protein Expression in a Chronic Carrier

1993 • 139 citations

Regulation of secretion of the hepatitis B virus major surface antigen by the preS-1 protein

1987 • 130 citations

Pre-S2 defective hepatitis B virus infection in patients with fulminant hepatitis

1997 • 106 citations

Hepatitis B virus genomes that cannot synthesize pre-S2 proteins occur frequently and as dominant virus populations in chronic carriers in Italy

1992 • 100 citations

Assembly of viral particles in Xenopus oocytes: pre-surface-antigens regulate secretion of the hepatitis B viral surface envelope particle.

1986 • 98 citations

Hypermodification and Immune Escape of an Internally Deleted Middle-Envelope (M) Protein of Frequent and Predominant Hepatitis B Virus Variants

2002 • 97 citations

Both Pre-S1 and S Domains of Hepatitis B Virus Envelope Proteins Interact with the Core Particle

1997 • 95 citations

Complex HBV populations with mutations in core promoter, C gene, and pre-S region are associated with development of cirrhosis in long-term renal transplant recipients

2002 • 87 citations

Quantification of intrahepatic hepatitis B virus (HBV) DNA in patients with chronic HBV infection

2000 • 77 citations

Formation of intracellular particles by hepatitis B virus large surface protein

1997 • 69 citations

Cellular vacuolization and apoptosis induced by hepatitis B virus large surface protein

2002 • 64 citations

PreS and Core Gene Heterogeneity in Hepatitis B Virus (HBV) Genomes Isolated from Patients with Long-Lasting HBV Chronic Infection

1995 • 59 citations

Cellular vacuolization and apoptosis induced by hepatitis B virus large surface protein

2002 • 53 citations

Genomic heterogeneity of hepatitis B virus (HBV) and outcome of perinatal HBV infection

2002 • 50 citations

Neonatal Fulminant Hepatitis B: Structural and Functional Analysis of Complete Hepatitis B Virus Genomes from Mother and Infant

1998 • 45 citations

Revisiting the cytopathic effect of hepatitis B virus infection

2002 • 19 citations

Revisiting the cytopathic effect of hepatitis B virus infection

2002 • 16 citations