Nomenclature for antiviral-resistant human hepatitis B virus mutations in the polymerase region

A One-Year Trial of Lamivudine for Chronic Hepatitis B

1998 • 1,779 citations

Structure of a Covalently Trapped Catalytic Complex of HIV-1 Reverse Transcriptase: Implications for Drug Resistance

1998 • 1,420 citations

Identification of four conserved motifs among the RNA-dependent polymerase encoding elements.

1989 • 1,195 citations

LAMIVUDINE AS INITIAL TREATMENT FOR CHRONIC HEPATITIS B IN THE UNITED STATES

1999 • 1,119 citations

Vaccine-induced escape mutant of hepatitis B virus

1990 • 1,081 citations

Typing Hepatitis B Virus by Homology in Nucleotide Sequence: Comparison of Surface Antigen Subtypes

1988 • 1,057 citations

Viral dynamics in hepatitis B virus infection.

1996 • 1,013 citations

Nucleotide sequence of the hepatitis B virus genome (subtype ayw) cloned in E. coli

1979 • 992 citations

Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B

2000 • 940 citations

A new genotype of hepatitis B virus: complete genome and phylogenetic relatedness

2000 • 923 citations

Complete Genomes, Phylogenetic Relatedness, and Structural Proteins of Six Strains of the Hepatitis B Virus, Four of Which Represent Two New Genotypes

1994 • 804 citations

Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site.

1999 • 730 citations

Selection of mutations in the hepatitis B virus polymerase during therapy of transplant recipients with lamivudine

1996 • 470 citations

Long-term incidence of hepatitis B virus resistance to lamivudine in human immunodeficiency virus-infected patients

1999 • 431 citations

Mutational analysis of the hepatitis B virus P gene product: domain structure and RNase H activity

1990 • 355 citations

Clinical relevance of hepatitis B viral mutations

2000 • 348 citations

Cloning and structural analyses of hepatitis B virus DNAs, subtypeadr

1983 • 309 citations

Nucleotide sequence of a cloned woodchuck hepatitis virus genome: comparison with the hepatitis B virus sequence

1982 • 296 citations

Multicenter Study of Lamivudine Therapy for Hepatitis B After Liver Transplantation

1999 • 291 citations

THE NUCLEOTIDE SEQUENCE OF THE HEPATITIS B VIRAL GENOME AND THE IDENTIFICATION OF THE MAJOR VIRAL GENES

1980 • 277 citations

Hepatitis B virus genotype A rarely circulates as an HBe-minus mutant: possible contribution of a single nucleotide in the precore region

1993 • 266 citations

Reverse transcription in hepatitis B viruses is primed by a tyrosine residue of the polymerase

1994 • 249 citations

Hepatitis B virus genotype assignment using restriction fragment length polymorphism patterns

1999 • 247 citations

Host-independent evolution and a genetic classification of the hepadnavirus family based on nucleotide sequences.

1989 • 221 citations

Loss of the common "A" determinant of hepatitis B surface antigen by a vaccine-induced escape mutant.

1992 • 211 citations

Isolation of a hepadnavirus from the woolly monkey, a New World primate

1998 • 210 citations

Efficacy and Safety of Adefovir Dipivoxil With Antiretroviral Therapy<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>

1999 • 203 citations

Line Probe Assay for Monitoring Drug Resistance in Hepatitis B Virus-Infected Patients during Antiviral Therapy

2000 • 183 citations

Hepadnavirus P protein utilizes a tyrosine residue in the TP domain to prime reverse transcription

1994 • 164 citations

Nucleotide Sequence of a Cloned Hepatitis B Virus Genome, Subtype ayr: Comparison with Genomes of the Other Three Subtypes

1986 • 163 citations

Nucleotide sequence of an infectious molecularly cloned genome of ground squirrel hepatitis virus

1984 • 155 citations

High pre-treatment serum hepatitis B virus titre predicts failure of lamivudine prophylaxis and graft re-infection after liver transplantation

1999 • 153 citations

Hepatitis B virus replication‐an update

1996 • 148 citations

The effects of dNTP pool imbalances on frameshift fidelity during DNA replication.

1992 • 142 citations

G-->A hypermutation of the human immunodeficiency virus type 1 genome: evidence for dCTP pool imbalance during reverse transcription.

1994 • 140 citations

Susceptibility of lamivudine-resistant hepatitis B virus to other reverse transcriptase inhibitors

1999 • 135 citations

Mutations in retroviral genes associated with drug resistance : 2000-2001 update

2000 • 132 citations

Hepatitis B defective virus with rearrangements in the PreS gene during chronic HBV infection

1991 • 132 citations

Mutational pattern of hepatitis B virus on sequential therapy with famciclovir and lamivudine in patients with hepatitis B virus reinfection occurring under hbig immunoglobulin after liver transplantation

1999 • 127 citations

The Complete Nucleotide Sequence of the Genome of a Hepatitis B Virus Isolated from a Naturally Infected Chimpanzee

1988 • 125 citations

A placebo‐controlled phase I/II study of adefovir dipivoxil in patients with chronic hepatitis B virus infection

1999 • 114 citations

Detection of Hepatitis B Virus Infection in Wild-Born Chimpanzees ( Pan troglodytes verus ): Phylogenetic Relationships with Human and Other Primate Genotypes

2000 • 106 citations

Complete Sequencing of a Gibbon Hepatitis B Virus Genome Reveals a Unique Genotype Distantly Related to the Chimpanzee Hepatitis B Virus

1996 • 103 citations

Antigenic Diversity of Hepatitis B Virus Strains of Genotype F in Amerindians and Other Population Groups from Venezuela

1998 • 103 citations

Hepatitis B Virus Replication: Novel Roles for Virus-Host Interactions

1999 • 101 citations

A New Group of Hepadnaviruses Naturally Infecting Orangutans ( Pongo pygmaeus )

1999 • 99 citations

A new hepadnavirus endemic in arctic ground squirrels in Alaska

1996 • 93 citations

Molecular Epidemiology of Hepatitis B Virus Variants in Nonhuman Primates

2000 • 87 citations

Naturally Occurring Hepatitis B Virus Genomes Bearing the Hallmarks of Retroviral G → A Hypermutation

1997 • 79 citations

Translation of the hepatitis B virus P gene by ribosomal scanning as an alternative to internal initiation

1993 • 79 citations

In vitro evaluation of hepatitis B virus polymerase mutations associated with famciclovir resistance

2000 • 72 citations

Therapies for viral hepatitis.

1998 • 67 citations

A heptanucleotide sequence mediates ribosomal frameshifting in mammalian cells

1993 • 64 citations

PreS and Core Gene Heterogeneity in Hepatitis B Virus (HBV) Genomes Isolated from Patients with Long-Lasting HBV Chronic Infection

1995 • 59 citations

Mapping of the Hepatitis B Virus Reverse Transcriptase TP and RT Domains by Transcomplementation for Nucleotide Priming and by Protein-Protein Interaction

1999 • 56 citations

Persistence of viral replication after anti-HBe seroconversion during antiviral therapy for chronic hepatitis B

2000 • 54 citations

HEPATITIS B OUTBREAK AMONG CHIMPANZEES AT THE LONDON ZOO

1978 • 50 citations

Evidence for involvement of a ribosomal leaky scanning mechanism in the translation of the hepatitis B virus Pol gene from the viral pregenome RNA

1992 • 50 citations

Mutations in the hepatitis B virus polymerase gene associated with antiviral treatment for hepatitis B

1999 • 49 citations

Translational regulation of hepatitis B virus polymerase gene by termination-reinitiation of an upstream minicistron in a length-dependent manner.

1998 • 42 citations

Typing of hepatitis B virus genomes by a simplified polymerase chain reaction

1990 • 42 citations

Relationships between serotypes and genotypes of hepatitis B virus: genetic classification of HBV by use of surface genes

1995 • 34 citations

Significance of mutations in the hepatitis B virus polymerase selected by nucleoside analogues and implications for controlling chronic disease

1998 • 34 citations

PreS1 deleted variants of hepatitis B virus in patients with chronic hepatitis

1994 • 33 citations

Expression, Purification, and Characterization of an Active RNase H Domain of the Hepatitis B Viral Polymerase

1996 • 24 citations

Mutations in the hepatitis B virus DNA polymerase associated with antiviral resistance

1998 • 21 citations

Unique Pre-S Sequence in a Gibbon-Derived Hepatitis B Virus Variant

1993 • 18 citations

Hepatitis B virus: DNA polymerase activity of deletion mutants

1999 • 13 citations

Polymerase chain reaction can resolve some undefined cases of Hepatitis B virus antigenic subtyping

1994 • 7 citations

Decreased replication capacity of a duck hepatitis B virus mutant with altered distal pre-S region

1991 • 7 citations