The PreS2 Activators of the Hepatitis B Virus: Activators of Tumour Promoter Pathways

HEPATOCELLULAR CARCINOMA AND HEPATITIS B VIRUS

1981 • 2,891 citations

Universal Hepatitis B Vaccination in Taiwan and the Incidence of Hepatocellular Carcinoma in Children

1997 • 1,836 citations

Hepatitis B virus.The major etiology of hepatocellular carcinoma

1988 • 1,308 citations

Protein Oligomerization in the Endoplasmic Reticulum

1989 • 993 citations

Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice

1989 • 692 citations

Hepatocellular carcinoma and the hepatitis B virus: evidence for a causal association.

1978 • 588 citations

Estimates of the worldwide frequency of twelve major cancers.

1984 • 434 citations

Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade.

1994 • 418 citations

Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway

1993 • 371 citations

Hepatitis B virus HBx protein deregulates cell cycle checkpoint controls.

1995 • 286 citations

The preS2/S region of integrated hepatitis B virus DNA encodes a transcriptional transactivator

1990 • 284 citations

A Transgenic Mouse Model of the Chronic Hepatitis B Surface Antigen Carrier State

1985 • 281 citations

Transcriptional trans-activating function of hepatitis B virus

1987 • 280 citations

eps15, a novel tyrosine kinase substrate, exhibits transforming activity.

1993 • 265 citations

Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice

1986 • 264 citations

X-irradiation, phorbol esters, and H2O2 stimulate mitogen-activated protein kinase activity in NIH-3T3 cells through the formation of reactive oxygen intermediates.

1994 • 247 citations

Oxygen and the control of gene expression

1994 • 245 citations

Hepatitis B virus transactivator MHBst: activation of NF-kappa B, selective inhibition by antioxidants and integral membrane localization.

1992 • 204 citations

Post-translational alterations in transmembrane topology of the hepatitis B virus large envelope protein.

1994 • 202 citations

Structural Relationships Between Minor and Major Proteins of Hepatitis B Surface Antigen

1983 • 196 citations

Hepatitis B virus transgenic mice: Insights into the virus and the disease*1

1995 • 176 citations

A transactivating function encoded in the hepatitis B virus X gene is conserved in the integrated state.

1988 • 174 citations

The HBV X-ORF encodes a transactivator: a potential factor in viral hepatocarcinogenesis.

1988 • 161 citations

A dramatic shift in the transmembrane topology of a viral envelope glycoprotein accompanies hepatitis B viral morphogenesis.

1994 • 150 citations

The Hepatitis B Virus Large Surface Protein (LHBs) Is a Transcriptional Activator

1996 • 147 citations

Assembly of Hepadnaviral Virions and Subviral Particles

1991 • 146 citations

A trans-activator function is generated by integration of hepatitis B virus preS/S sequences in human hepatocellular carcinoma DNA.

1990 • 145 citations

Hepatitis B Virus Transgenic Mice: Models of Viral Immunobiology and Pathogenesis

1996 • 134 citations

Ras- and Raf-dependent activation of c-jun transcriptional activity by the hepatitis B virus transactivator pX.

1994 • 128 citations

Integrated hepatitis B virus X and 3' truncated preS/S sequences derived from human hepatomas encode functionally active transactivators.

1994 • 119 citations

Cellular and Molecular Mechanisms of Hepatocarcinogenesis

1992 • 67 citations

The hepatitis B virus pre-S/S(t) transactivator is generated by 3' truncations within a defined region of the S gene

1992 • 67 citations

Characterization of essential domains for the functionality of the MHBst transcriptional activator and identification of a minimal MHBst activator.

1995 • 65 citations

Trans-Activation of Cellular Genes By Hepatitis B Virus Proteins: A Possible Mechanism of Hepatocarcinogenesis

1996 • 64 citations

Isolation and molecular characterization of hepatitis B virus X-protein from a baculovirus expression system

1997 • 47 citations

The hepatitis B virus PreS2/St transactivator utilizes AP-1 and other transcription factors for transactivation

1994 • 46 citations

A chromosome 17:7 translocation is associated with a hepatitis B virus DNA integration in human hepatocellular carcinoma DNA

1992 • 38 citations

Characterization of the hepatitis B virus preS/S region encoded transcriptional transactivator

1992 • 37 citations

Anti-hepatitis B virus activity of N-acetyl-l-cysteine (NAC): new aspects of a well-established drug

1996 • 34 citations

ER-localization and functional expression of the HBV transactivator MHBst.

1993 • 33 citations

Synergy between transforming growth factor alpha and hepatitis B virus surface antigen in hepatocellular proliferation and carcinogenesis.

1997 • 32 citations

Host Cell-Virus Cross Talk: Phosphorylation of a Hepatitis B Virus Envelope Protein Mediates Intracellular Signaling

1998 • 31 citations

The role of hepatitis B virus (HBV) in the development of hepatocellular carcinoma

1996 • 29 citations

Mammalian hepatitis B viruses and primary liver cancer.

1992 • 26 citations

Isolation of Highly Purified, Functional Carboxy–Terminally Truncated Hepatitis B Virus Middle Surface Protein Activators From Eucaryotic Expression Systems

1996 • 18 citations

Transactivation of Cellular Promoters by an Integrated Hepatitis B virus DNA

1993 • 11 citations