The Dopamine Transporter and Attention-Deficit/Hyperactivity Disorder

Diagnosis and Treatment of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents

1998 • 1,095 citations

Atomoxetine Increases Extracellular Levels of Norepinephrine and Dopamine in Prefrontal Cortex of Rat A Potential Mechanism for Efficacy in Attention Deficit/Hyperactivity Disorder

2002 • 1,092 citations

Association of attention-deficit disorder and the dopamine transporter gene.

1995 • 1,023 citations

Does Stimulant Therapy of Attention-Deficit/Hyperactivity Disorder Beget Later Substance Abuse? A Meta-analytic Review of the Literature

2003 • 856 citations

Trace amines: Identification of a family of mammalian G protein-coupled receptors

2001 • 855 citations

Pharmacotherapy of Attention-Deficit Hyperactivity Disorder across the Life Cycle

1996 • 846 citations

Dopamine Uptake through the Norepinephrine Transporter in Brain Regions with Low Levels of the Dopamine Transporter: Evidence from Knock-Out Mouse Lines

2002 • 661 citations

Atomoxetine in the Treatment of Children and Adolescents With Attention-Deficit/Hyperactivity Disorder: A Randomized, Placebo-Controlled, Dose-Response Study

2001 • 661 citations

Amphetamine, 3,4-Methylenedioxymethamphetamine, Lysergic Acid Diethylamide, and Metabolites of the Catecholamine Neurotransmitters Are Agonists of a Rat Trace Amine Receptor

2001 • 598 citations

Cloning and Expression of a Cocaine-Sensitive Rat Dopamine Transporter

1991 • 587 citations

The dopamine transporter: immunochemical characterization and localization in brain

1995 • 586 citations

Cortical abnormalities in children and adolescents with attention-deficit hyperactivity disorder

2003 • 565 citations

Genotype Influences In Vivo Dopamine Transporter Availability in Human Striatum

2000 • 550 citations

Increased striatal dopamine transporter in adult patients with attention deficit hyperactivity disorder: effects of methylphenidate as measured by single photon emission computed tomography

2000 • 517 citations

Attention-deficit/hyperactivity disorder (adhd) as a noradrenergic disorder

1999 • 502 citations

Confirmation of association between attention deficit hyperactivity disorder and a dopamine transporter polymorphism

1997 • 498 citations

Monoamine transporters and psychostimulant drugs

2003 • 489 citations

Is ADHD a Risk Factor for Psychoactive Substance Use Disorders? Findings From a Four-Year Prospective Follow-up Study

1997 • 487 citations

American Medical Association Council on Scientific Affairs

1988 • 477 citations

Studies on the distinction between uptake inhibition and release of [3H]dopamine in rat brain tissue slices

1975 • 473 citations

The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons

1996 • 473 citations

Prospective Study of Tobacco Smoking and Substance Dependencies Among Samples of ADHD and Non-ADHD Participants

1998 • 468 citations

Association and Linkage of the Dopamine Transporter Gene and Attention-Deficit Hyperactivity Disorder in Children: Heterogeneity owing to Diagnostic Subtype and Severity

1998 • 467 citations

Catecholamines in Attention-Deficit Hyperactivity Disorder: Current Perspectives

1996 • 449 citations

Multiple Ionic Conductances of the Human Dopamine Transporter: The Actions of Dopamine and Psychostimulants

1997 • 448 citations

The VNTR polymorphism of the human dopamine transporter (DAT1) gene affects gene expression

2001 • 424 citations

Amphetamine-induced loss of human dopamine transporter activity: An internalization-dependent and cocaine-sensitive mechanism

2000 • 410 citations

Blockade of the Noradrenaline Carrier Increases Extracellular Dopamine Concentrations in the Prefrontal Cortex: Evidence that Dopamine Is Taken up In Vivo by Noradrenergic Terminals

1990 • 407 citations

A review of the biological bases of ADHD: What have we learned from imaging studies?

2003 • 391 citations

Mapping susceptibility loci in attention deficit hyperactivity disorder: preferential transmission of parental alleles at DAT1, DBH and DRD5 to affected children

1999 • 390 citations

Dopamine can be released by two mechanisms differentially affected by the dopamine transport inhibitor nomifensine.

1979 • 382 citations

Amphetamine and other psychostimulants reduce pH gradients in midbrain dopaminergic neurons and chromaffin granules: A mechanism of action

1990 • 380 citations

Stable expression of biogenic amine transporters reveals differences in inhibitor sensitivity, kinetics, and ion dependence.

1994 • 375 citations

Monoamine Transporters: From Genes to Behavior

2003 • 375 citations

DAncing past the DAT at a DA synapse

2004 • 370 citations

Regulated Trafficking of the Human Dopamine Transporter

1999 • 357 citations

Dopamine transporter immunoreactivity in monkey cerebral cortex: Regional, laminar, and ultrastructural localization

2001 • 355 citations

Attention-deficit/hyperactivity disorder: a life-span perspective.

1998 • 352 citations

Neurobiology of Attention Deficit Disorder With Hyperactivity: Where Have We Come in 50 Years?

1987 • 351 citations

Functional Interaction between Monoamine Plasma Membrane Transporters and the Synaptic PDZ Domain–Containing Protein PICK1

2001 • 344 citations

Expression of the dopamine transporter gene is regulated by the 3′ UTR VNTR: Evidence from brain and lymphocytes using quantitative RT‐PCR

2002 • 337 citations

Mechanism of action of methylphenidate: Insights from PET imaging studies

2002 • 336 citations

Delineation of discrete domains for substrate, cocaine, and tricyclic antidepressant interactions using chimeric dopamine-norepinephrine transporters.

1994 • 326 citations

Relationship between blockade of dopamine transporters by oral methylphenidate and the increases in extracellular dopamine: Therapeutic implications

2001 • 315 citations

Striatal Dopamine Transporters and Cognitive Functioning in Healthy Men and Women

2001 • 308 citations

Methylphenidate and dextroamphetamine treatments of hyperactivity: Are there true nonresponders?

1991 • 300 citations

Role of dopamine transporter genotype and maternal prenatal smoking in childhood hyperactive-impulsive, inattentive, and oppositional behaviors

2003 • 295 citations

Subcellular localization and molecular topology of the dopamine transporter in the striatum and substantia nigra

1997 • 290 citations

Attention deficit hyperactivity disorder: binding of [99mTc]TRODAT-1 to the dopamine transporter before and after methylphenidate treatment

2000 • 285 citations

Oligomerization and Trafficking of the Human Dopamine Transporter

2003 • 279 citations

Prediction of Dopamine Transporter Binding Availability by Genotype: A Preliminary Report

2000 • 279 citations

Polygenic inheritance of Tourette syndrome, stuttering, attention deficit hyperactivity, conduct, and oppositional defiant disorder: The additive and subtractive effect of the three dopaminergic genes—DRD2, DβH, and DAT1

1996 • 271 citations

Abnormal dopamine uptake sites in postmortem striatum from patients with tourette's syndrome

1991 • 269 citations

ATTENTION-DEFICIT/HYPERACTIVITY DISORDER AND COMORBIDITY

1999 • 267 citations

Anti-hyperactivity medication: methylphenidate and amphetamine

1998 • 262 citations

Attention-deficit/hyperactivity disorder and the substance use disorders: the nature of the relationship, subtypes at risk, and treatment issues

2004 • 258 citations

The Dopamine Transporter Constitutively Internalizes and Recycles in a Protein Kinase C-regulated Manner in Stably Transfected PC12 Cell Lines

2003 • 257 citations

Association of the Dopamine Transporter Gene (DAT1) With Poor Methylphenidate Response

1999 • 256 citations

Methylphenidate treatment during pre- and periadolescence alters behavioral responses to emotional stimuli at adulthood

2003 • 253 citations

Cocaine receptors labeled by [3H]2 beta-carbomethoxy-3 beta-(4-fluorophenyl)tropane.

1989 • 248 citations

Development of a New Once-a-Day Formulation of Methylphenidate for the Treatment of Attention-deficit/Hyperactivity Disorder

2003 • 244 citations

Enduring behavioral effects of early exposure to methylphenidate in rats

2003 • 244 citations

Dopamine transporter–mediated conductances increase excitability of midbrain dopamine neurons

2002 • 236 citations

Polymorphisms in the 3′-untranslated region of human and monkey dopamine transporter genes affect reporter gene expression

2002 • 231 citations

[123I]beta-CIT SPECT imaging of striatal dopamine transporter binding in Tourette's disorder

1995 • 226 citations

A human dopamine transporter cDNA predicts reduced glycosylation, displays a novel repetitive element and provides racially-dimorphic TaqI RFLPs

1992 • 222 citations

Stimulant drugs and ADHD : basic and clinical neuroscience

2001 • 219 citations

Cocaine Increases Dopamine Uptake and Cell Surface Expression of Dopamine Transporters

2002 • 213 citations

Dendrodendritic Inhibition Through Reversal of Dopamine Transport

2001 • 212 citations

Acute tolerance to methylphenidate in the treatment of attention deficit hyperactivity disorder in children*

1999 • 211 citations

Characteristics of drug interactions with recombinant biogenic amine transporters expressed in the same cell type.

1999 • 207 citations

Current concepts on the neurobiology of Attention-Deficit/Hyperactivity Disorder

2002 • 203 citations

The dopamine transporter gene (SLC6A3) variable number of tandem repeats domain enhances transcription in dopamine neurons

2001 • 195 citations

Oligomerization of Dopamine Transporters Visualized in Living Cells by Fluorescence Resonance Energy Transfer Microscopy

2003 • 194 citations

The Role of N-Glycosylation in Function and Surface Trafficking of the Human Dopamine Transporter

2004 • 189 citations

The Variable Number of Tandem Repeats Polymorphism of the Dopamine Transporter Gene Is Not Associated with Significant Change in Dopamine Transporter Phenotype in Humans

2001 • 187 citations

Dynamic regulation of the dopamine transporter

2003 • 186 citations

The dopamine transporter and neuroimaging in attention deficit hyperactivity disorder

2003 • 185 citations

Dopamine transporter density in the basal ganglia assessed with [123I]IPT SPET in children with attention deficit hyperactivity disorder

2003 • 185 citations

Neurochemical and behavioral differences between d-methamphetamine and d-amphetamine in rats

2003 • 184 citations

A new inhibitor of norepinephrine uptake devoid of affinity for receptors in rat brain.

1982 • 184 citations

Cocaine Induction of Dopamine Transporter Trafficking to the Plasma Membrane

2002 • 178 citations

Attention‐deficit hyperactivity disorder: A study of association with both the dopamine transporter gene and the dopamine D4 receptor gene

2001 • 175 citations

Haplotype study of three polymorphisms at the dopamine transporter locus confirm linkage to attention-deficit/hyperactivity disorder

2001 • 172 citations

Inability to N-glycosylate the human norepinephrine transporter reduces protein stability, surface trafficking, and transport activity but not ligand recognition.

1996 • 169 citations

Serum and brain concentrations of methylphenidate: implications for use and abuse

2003 • 167 citations

Stimulant Drugs and ADHD: Basic and Clinical Neuroscience

2002 • 166 citations

Functional Effects of the DAT1 Polymorphism on EEG Measures in ADHD

2003 • 165 citations

Trace amine receptors as targets for novel therapeutics: legend, myth and fact

2003 • 160 citations

Dopamine genes and attention-deficit hyperactivity disorder: a review.

2003 • 159 citations

α‐Synuclein regulation of the dopaminergic transporter: a possible role in the pathogenesis of Parkinson's disease

2004 • 159 citations

Association study of a dopamine transporter polymorphism and attention deficit hyperactivity disorder in UK and Turkish samples

2001 • 156 citations

Association of the 480 bp DAT1 allele with methylphenidate response in a sample of Irish children with ADHD

2003 • 153 citations

A family-based and case-control association study of the dopamine D4 receptor gene and dopamine transporter gene in attention deficit hyperactivity disorder

2000 • 152 citations

Early Methylphenidate Administration to Young Rats Causes a Persistent Reduction in the Density of Striatal Dopamine Transporters

2001 • 147 citations

Attention-Deficit/Hyperactivity Disorder and Substance Use: Symptom Pattern and Drug Choice

1999 • 138 citations

Unaltered Dopamine Transporter Availability in Adult Attention Deficit Hyperactivity Disorder

2002 • 138 citations

Dopamine transporter gene and response to methylphenidate in attention-deficit/hyperactivity disorder

2002 • 137 citations

Dopamine and nicotinic receptor binding and the levels of dopamine and homovanillic acid in human brain related to tobacco use

1998 • 136 citations

Differential effects of psychostimulants and related agents on dopaminergic and serotonergic transporter function

1999 • 132 citations

Regulation of the vesicular monoamine transporter-2: a novel mechanism for cocaine and other psychostimulants.

2001 • 130 citations

Cerebrospinal Fluid Homovanillic Acid Predicts Behavioral Response to Stimulants in 45 Boys with Attention Deficit/Hyperactivity Disorder

1996 • 126 citations

Methylphenidate elevates resting dopamine which lowers the impulse-triggered release of dopamine: a hypothesis

2002 • 124 citations

Methylphenidate Down-Regulates the Dopamine Receptor and Transporter System in Children with Attention Deficit Hyperkinetic Disorder (ADHD)

2003 • 123 citations

Methylphenidate Redistributes Vesicular Monoamine Transporter-2: Role of Dopamine Receptors

2002 • 119 citations

Rapid detection of Parkinson's disease by SPECT with altropane: A selective ligand for dopamine transporters

1998 • 117 citations

Inhibitory Effects of Nitric Oxide on the Uptake of [³H]Dopamine and [³H]Glutamate by Striatal Synaptosomes

1994 • 117 citations

Rapid regulation of dopamine transporter function by substrates, blockers and presynaptic receptor ligands

2003 • 111 citations

Structure‐activity relations for the inhibition of catecholamine uptake into synaptosomes from noradrenaline and dopaminergic neurones in rat brain homogenates

1973 • 109 citations

Greater Availability of Brain Dopamine Transporters in Major Depression Shown by [^99mTc]TRODAT-1 SPECT Imaging

2003 • 105 citations

The dopamine transporter gene is associated with attention deficit hyperactivity disorder in a Taiwanese sample

2003 • 101 citations

Repeated methylphenidate treatment in adolescent rats alters gene regulation in the striatum

2003 • 100 citations

Psychoactive drugs in the immature organism

1970 • 100 citations

The dopamine transporter: relevance to attention deficit hyperactivity disorder (ADHD)

2002 • 98 citations

Association of Norepinephrine Transporter Gene With Methylphenidate Response

2004 • 96 citations

Intracellular Ca²⁺Regulates Amphetamine-Induced Dopamine Efflux and Currents Mediated by the Human Dopamine Transporter

2004 • 95 citations

Dopamine transporter binding in Gilles de la Tourette syndrome

2000 • 94 citations

Alpha₂‐adrenoceptor mediated co‐release of dopamine and noradrenaline from noradrenergic neurons in the cerebral cortex

2004 • 91 citations

Autoradiographic localization of cocaine binding sites by [³H]CFT ([³H]WIN 35,428) in the monkey brain

1990 • 90 citations

Drug Therapy for Adults with Attention-Deficit Hyperactivity Disorder

2003 • 89 citations

Stimulant drug treatment of hyperactivity: Biochemical correlates

1990 • 87 citations

Functional expression of the norepinephrine transporter in cultured rat astrocytes

2002 • 81 citations

No association of the dopamine transporter gene 3′ VNTR polymorphism with ADHD subtypes in a population sample of twins

2001 • 81 citations

Phenylethylaminergic mechanisms in attention-deficit disorder

1991 • 81 citations

Novel treatments for attention-deficit/hyperactivity disorder in children.

2002 • 80 citations

No evidence of linkage or linkage disequilibrium between DAT1 and attention deficit hyperactivity disorder in a large sample

1999 • 79 citations

Inhibition of [3H]dopamine accumulation in rat striatal synaptosomes by psychotropic drugs

1978 • 72 citations

Chronic methylphenidate alters locomotor activity and dopamine transporters differently from cocaine

1999 • 71 citations

Differences between d -methamphetamine and d -amphetamine in rats: working memory, tolerance, and extinction

2003 • 66 citations

Inhibition of mouse brain monoamine oxidase by (+)-amphetamine in vivo

1978 • 64 citations

Variation of variable number of tandem repeat sequences in the 3′-untranslated region of primate dopamine transporter genes that affects reporter gene expression

2002 • 63 citations

Regulation of the functional activity of the human dopamine transporter by the arachidonic acid pathway

1996 • 63 citations

Drugs used in the treatment of attention-deficit/hyperactivity disorder affect postsynaptic firing rate and oscillation without preferential dopamine autoreceptor action

2001 • 61 citations

Absence of tolerance to the behavioral effects of methylphenidate in hyperactive and inattentive children

1989 • 59 citations

[11C,127I] Altropane: A highly selective ligand for PET imaging of dopamine transporter sites

2001 • 57 citations

No change in striatal dopamine re-uptake site density in psychotropic drug naive and in currently treated Tourette’s disorder patients: a [123I]-β-CIT SPECT-study

2001 • 51 citations

Non-stimulant treatment for Attention-Deficit/Hyperactivity Disorder

2002 • 50 citations

Determination of Residues in the Norepinephrine Transporter That Are Critical for Tricyclic Antidepressant Affinity

2001 • 49 citations

Increased urine phenylethylamine after methylphenidate treatment in children with ADHD

2002 • 49 citations

Daily methylphenidate administration attenuates c-fos expression in the striatum of prepubertal rats

2003 • 47 citations

[3H]PNU-101958, a D4 dopamine receptor probe, accumulates in prefrontal cortex and hippocampus of non-human primate brain

2000 • 45 citations

Ethanol potentiates the function of the human dopamine transporter expressed inXenopusoocytes

2001 • 45 citations

Single nucleotide polymorphisms distinguish multiple dopamine transporter alleles in primates: implications for association with attention deficit hyperactivity disorder and other neuropsychiatric disorders

2000 • 45 citations

The human dopamine transporter gene: the 5′-flanking region reveals five diallelic polymorphic sites in a Caucasian population sample

2001 • 43 citations

A Pharmacokinetic/Pharmacodynamic Study Comparing a Single Morning Dose of Adderall to Twice-Daily Dosing in Children With ADHD

2003 • 43 citations

Phenylethylamine Excretion in Attention Deficit Disorder

1984 • 42 citations

Effects of d-amphetamine on urinary metabolites of dopamine and norepinephrine in hyperactive boys

1982 • 38 citations

Novel halogenated analogs of tomoxetine that are potent and selective inhibitors of norepinephrine uptake in brain

1995 • 38 citations

Dopamine transporter synthesis and degradation rate in rat striatum and nucleus accumbens using RTI-76

2000 • 38 citations

Differential Interactions of Desipramine with Amphetamine and Methamphetamine: Evidence that Amphetamine Releases Dopamine from Noradrenergic Neurons in the Medial Prefrontal Cortex

2004 • 36 citations

Alterations in Vesicular Dopamine Uptake Contribute to Tolerance to the Neurotoxic Effects of Methamphetamine

2004 • 32 citations

Catecholamine uptake sites in mouse brain: distribution determined by quantitative [3H]mazindol autoradiography

1989 • 31 citations

Attention deficit and hyperactivity disorder: review of genetic association studies.

2003 • 27 citations

Dopamine transporter‐dependent induction of C‐Fos in HEK cells

2002 • 26 citations

Dopamine Transporter Genotype Influences the Attention Deficit in Korean Boys with ADHD

2003 • 25 citations

[Association studies of dopamine D4 receptor gene and dopamine transporter gene polymorphisms in Han Chinese patients with attention deficit hyperactivity disorder].

2003 • 21 citations

Efficacy of Adderall and Methylphenidate in Attention Deficit Hyperactivity Disorder: A Reanalysis Using Drug–Placebo and Drug–Drug Response Curve Methodology

2001 • 18 citations

Urinary phenethylamine response to d-amphetamine in 12 boys with attention deficit disorder

1984 • 12 citations

Attention deficit and hyperactivity disorder

2007 • 12 citations

Deleted Work

1955 • 0 citations