[3H]PNU-101958, a D4 dopamine receptor probe, accumulates in prefrontal cortex and hippocampus of non-human primate brain

Dopamine Receptors: From Structure to Function

1998 • 3,489 citations

Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine

1991 • 2,008 citations

Multiple dopamine D4 receptor variants in the human population

1992 • 967 citations

Neurobiology of attention-deficit hyperactivity disorder

1998 • 815 citations

Dopamine D4 receptors elevated in schizophrenia

1993 • 632 citations

Mismatches between neurotransmitter and receptor localizations in brain: observations and implications

1987 • 524 citations

Localization of dopamine D4 receptors in GABAergic neurons of the primate brain

1996 • 494 citations

Mice Lacking Dopamine D4 Receptors Are Supersensitive to Ethanol, Cocaine, and Methamphetamine

1997 • 480 citations

Enduring Cognitive Deficits and Cortical Dopamine Dysfunction in Monkeys After Long-Term Administration of Phencyclidine

1997 • 401 citations

Association of the dopamine receptor D4 (DRD4) gene with a refined phenotype of attention deficit hyperactivity disorder (ADHD): a family-based approach

1998 • 383 citations

A stereotaxic atlas of the monkey brain : (Macaca mulatta)

1961 • 281 citations

Differential regional and cellular distribution of dopamine D2-like receptors: An immunocytochemical study of subtype-specific antibodies in rat and human brain

1998 • 267 citations

The Dopamine Receptors

1997 • 260 citations

Evidence that the dopamine D4 receptor is a susceptibility gene in attention deficit hyperactivity disorder

1998 • 222 citations

Dopamine DRD4 receptor polymorphism and attention deficit hyperactivity disorder

1998 • 219 citations

The Effects of a Selective D4 Dopamine Receptor Antagonist (L-745,870) in Acutely Psychotic Inpatients With Schizophrenia

1997 • 195 citations

Cellular distribution of the rat D4 dopamine receptor protein in the CNS using anti-receptor antisera

1997 • 195 citations

D4 Dopamine-Receptor (DRD4) Alleles and Novelty Seeking in Substance-Dependent, Personality-Disorder, and Control Subjects

1997 • 191 citations

Stereotaxic atlas of the monkey brain (Macaca mulatta)

1962 • 184 citations

Excess dopamine D4 receptor (D4DR) exon III seven repeat allele in opioid-dependent subjects

1997 • 181 citations

Distribution of putative D4 dopamine receptors in postmortem striatum from patients with schizophrenia

1995 • 180 citations

Lack of an association between a dopamine-4 receptor polymorphism and attention-deficit/hyperactivity disorder: genetic and brain morphometric analyses

1998 • 170 citations

Depression and self-medication with nicotine: The modifying influence of the dopamine D4 receptor gene.

1998 • 168 citations

Biological profile of L-745,870, a selective antagonist with high affinity for the dopamine D4 receptor.

1997 • 161 citations

Depression and self-medication with nicotine: The modifying influence of the dopamine D4 receptor gene.

1998 • 161 citations

Distribution of D4 dopamine receptor in rat brain with sequence-specific antibodies

1997 • 152 citations

II. Localization and characterization of dopamine D4 binding sites in rat and human brain by use of the novel, D4 receptor-selective ligand [3H]NGD 94-1.

1997 • 151 citations

Genetic association study between pathological gambling and a functional DNA polymorphism at the D4 receptor gene

1997 • 147 citations

Additional evidence for an association between the dopamine D4 receptor (D4DR) exon III repeat polymorphism and the human personality trait of Novelty Seeking

1997 • 142 citations

Full-length cDNA cloning and distribution of human dopamine D4 receptor

1995 • 141 citations

Variability of dopamine D4 receptor (DRD4) gene sequence within and among nonhuman primate species.

1995 • 136 citations

Localization of dopamine receptor subtypes in corpus striatum and nucleus accumbens septi of rat brain: comparison of D1-, D2- and D4-like receptors

1998 • 121 citations

Dopamine D4 receptor exon III alleles and variation of novelty seeking in alcoholics

1997 • 121 citations

Dopamine D4 receptors and effects of guanine nucleotides on [3H]raclopride binding in postmortem caudate nucleus of subjects with schizophrenia or major depression

1995 • 121 citations

No association between Novelty Seeking and dopamine D4 receptor (D4DR) exon III seven repeat alleles in Baltimore Longitudinal Study of Aging participants

1997 • 117 citations

Linking the Family of D2 Receptors to Neuronal Circuits in Human Brain: Insights into Schizophrenia

1997 • 116 citations

Human novelty-seeking personality traits and dopamine D4 receptor polymorphisms: a twin and genetic association study.

1998 • 111 citations

Association analysis of the dopamine D4 gene exon III VNTR and heroin abuse in Chinese subjects

1997 • 98 citations

Human novelty-seeking personality traits and dopamine D4 receptor polymorphisms: a twin and genetic association study

1998 • 94 citations

Polymorphisms of the D4 Dopamine Receptor Alleles in Chronic Alcoholism

1993 • 91 citations

Altered frontal cortical dopaminergic transmission in monkeys after subchronic phencyclidine exposure: involvement in frontostriatal cognitive deficits

1999 • 91 citations

Low Levels of mRNA for Dopamine D4 Receptor in Human Cerebral Cortex and Striatum

1996 • 90 citations

Direct determination of dopamine D4 receptors in normal and schizophrenic postmortem brain tissue: a [3H]NGD-94-1 study

1998 • 87 citations

Dopamine D 4 receptor antagonist reversal of subchronic phencyclidine-induced object retrieval/detour deficits in monkeys

1999 • 86 citations

Review the role of dopamine D4 receptors in schizophrenia and antipsychotic action

1997 • 83 citations

Differential regulation of D2 and D4 dopamine receptor mRNAs in the primate cerebral cortex vs. neostriatum: effects of chronic treatment with typical and atypical antipsychotic drugs.

1997 • 82 citations

Polymorphisms of the dopamine D 4 receptor and response to antipsychotic drugs

1999 • 81 citations

Dopamine D4 receptor gene polymorphisms and neuroleptic response in schizophrenia

1998 • 77 citations

Regional distribution of dopamine D4 receptors in rat forebrain

1997 • 73 citations

The role of dopamine D4 receptor in the induction of behavioral sensitization to amphetamine and accompanying biochemical and molecular adaptations.

1998 • 73 citations

Dopamine D2 and D4 receptor ligands: relation to antipsychotic action

1998 • 72 citations

Dopamine D4 receptors: significance for molecular psychiatry at the millennium

1999 • 71 citations

Elevation of D4 dopamine receptor mRNA in postmortem schizophrenic brain

1998 • 70 citations

Recent advances in the pharmacotherapy of schxzophrenia

1994 • 70 citations

I. NGD 94-1: identification of a novel, high-affinity antagonist at the human dopamine D4 receptor.

1997 • 63 citations

D4 dopamine receptor-mediated phospholipid methylation and its implications for mental illnesses such as schizophrenia

1999 • 58 citations

Activation of midline thalamic nuclei by antipsychotic drugs

1998 • 53 citations

No evidence of association between dopamine D4 receptor variants and bipolar affective disorder

1994 • 51 citations

The agonist activities of the putative antipsychotic agents, L‐745,870 and U‐101958 in HEK293 cells expressing the human dopamine D_4.4 receptor

1998 • 46 citations

D2-type dopamine receptors in postmortem human brain sections from normal and schizophrenic subjects

1996 • 45 citations

Autoradiographic localization of the putative D4 dopamine receptor in rat brain.

1997 • 42 citations

RBI-257: A highly potent dopamine D4 receptor-selective ligand

1997 • 40 citations

The regional pattern of D4 gene expression in human brain

1997 • 36 citations

Genomic structure and tissue distribution of the mouse dopamine D4 receptor

1995 • 36 citations

Dopamine receptor D4 gene is associated with delusional symptomatology in mood disorders

1998 • 34 citations

Substituted 4-aminopiperidines having high in vitro affinity and selectivity for the cloned human dopamine D4 receptor

1997 • 31 citations

The Binding of Both [3H]Nemonapride and [3H]Raclopride Is Increased in Schizophrenia

1997 • 30 citations

Antipsychotic regulation of hippocampal dopamine receptor messenger RNA expression

1997 • 30 citations

Medial prefrontal cortical D2 and striatolimbic D4 dopamine receptors: Common targets for typical and atypical antepsychotic drugs

1998 • 27 citations

Polymorphic Tandem Repeats in Dopamine D4 Receptor Are Spread over Primate Species

1995 • 23 citations

Effects of cocaine on D3 and D4 receptor expression in the human striatum

1995 • 22 citations

Differential labeling of dopamine and sigma sites by [3H]nemonapride and [3H]raclopride in postmortem human brains

1997 • 22 citations

D4 receptors and their antagonists

1996 • 21 citations

Twelve-Nucleotide Repeat Polymorphism of D4 Dopamine Receptor Gene in Chinese Familial Schizophrenic Patients

1998 • 18 citations

Association of long variants of the dopamine D4 receptor exon 3 repeat polymorphism with Parkinson's disease

1998 • 16 citations

Non-amine dopamine transporter probe [3H]tropoxene distributes to dopamine-rich regions of monkey brain

1999 • 12 citations

Differential effects of [3H]nemonapride and [3H]spiperone binding on human dopamine D4 receptors

1995 • 12 citations

NGD 94-I: A Specific Dopamine-4-Receptor Antagonist

1997 • 10 citations

Neuropharmacological assessment of potential dopamine D4 receptor-selective radioligands

1999 • 10 citations

Dopamine D4-like Binding Sites Labeled by [3H]Nemonapride Include Substantial Serotonin 5-HT2A Receptors in Primate Cerebral Cortex

1999 • 8 citations

Dopamine D4 Receptors May Alleviate Antipsychotic-Induced Parkinsonism

1997 • 5 citations