Serum and brain concentrations of methylphenidate: implications for use and abuse
Data up to Jan 2025
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Abstract
References (49)
Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
1988 • 4,617 citations
A 14-Month Randomized Clinical Trial of Treatment Strategies for Attention-Deficit/Hyperactivity Disorder
1999 • 3,305 citations
Dopamine Transporter Occupancies in the Human Brain Induced by Therapeutic Doses of Oral Methylphenidate
1998 • 878 citations
Brain Reward Circuitry
2002 • 875 citations
Psychological heterogeneity in AD/HD—a dual pathway model of behaviour and cognition
2002 • 867 citations
Does Stimulant Therapy of Attention-Deficit/Hyperactivity Disorder Beget Later Substance Abuse? A Meta-analytic Review of the Literature
2003 • 856 citations
Minimal brain dysfunction in children
1971 • 825 citations
Therapeutic Doses of Oral Methylphenidate Significantly Increase Extracellular Dopamine in the Human Brain
2001 • 745 citations
Neuropsychopharmacological mechanisms of stimulant drug action in attention-deficit hyperactivity disorder: a review and integration
1998 • 686 citations
Relationship between subjective effects of cocaine and dopamine transporter occupancy
1997 • 653 citations
Effects of Methylphenidate on Extracellular Dopamine, Serotonin, and Norepinephrine: Comparison with Amphetamine
1997 • 613 citations
Attention-deficit hyperactivity disorder and hyperkinetic disorder
1998 • 582 citations
Is Methylphenidate Like Cocaine?
1995 • 575 citations
Attention-deficit hyperactivity disorder and hyperkinetic disorder
2001 • 567 citations
Randomized, Controlled Trial of OROS Methylphenidate Once a Day in Children With Attention-Deficit/Hyperactivity Disorder
2001 • 503 citations
Pharmacotherapy of Attention-deficit/Hyperactivity Disorder Reduces Risk for Substance Use Disorder
1999 • 488 citations
Variables That Affect the Clinical Use and Abuse of Methylphenidate in the Treatment of ADHD
2003 • 451 citations
“Nonhedonic” food motivation in humans involves dopamine in the dorsal striatum and methylphenidate amplifies this effect
2002 • 447 citations
Effects of cocaine and related drugs in nonhuman primates. III. Self-administration by squirrel monkeys.
1989 • 389 citations
Assessing the abuse potential of methylphenidate in nonhuman and human subjects: a review
2001 • 357 citations
Relationship between blockade of dopamine transporters by oral methylphenidate and the increases in extracellular dopamine: Therapeutic implications
2001 • 315 citations
Effect of Stimulant Medication on Children with Attention Deficit Disorder: A “Review of Reviews”
1993 • 314 citations
Expectation Enhances the Regional Brain Metabolic and the Reinforcing Effects of Stimulants in Cocaine Abusers
2003 • 304 citations
Impairment and Deportment Responses to Different Methylphenidate Doses in Children With ADHD: The MTA Titration Trial
2001 • 285 citations
Transient changes in mesolimbic dopamine and their association with ‘reward’
2002 • 282 citations
Evidence That Methylphenidate Enhances the Saliency of a Mathematical Task by Increasing Dopamine in the Human Brain
2004 • 269 citations
Anti-hyperactivity medication: methylphenidate and amphetamine
1998 • 262 citations
Development of a New Once-a-Day Formulation of Methylphenidate for the Treatment of Attention-deficit/Hyperactivity Disorder
2003 • 244 citations
A choice procedure for drug reinforcers: cocaine and methylphenidate in the rhesus monkey.
1975 • 235 citations
The Dopamine Theory of Attention Deficit Hyperactivity Disorder (ADHD)
1991 • 232 citations
Analog Classroom Assessment of Adderall® in Children With ADHD
1998 • 214 citations
Acute tolerance to methylphenidate in the treatment of attention deficit hyperactivity disorder in children*
1999 • 211 citations
Time-Response Analysis of the Effect of Stimulant Medication on the Learning Ability of Children Referred for Hyperactivity
1978 • 210 citations
A Double-Blind, Placebo-Controlled Study of Modified-Release Methylphenidate in Children With Attention-Deficit/Hyperactivity Disorder
2002 • 186 citations
Cost of Chickenpox in Canada: Part I. Cost of Uncomplicated Cases
1999 • 169 citations
Pharmacokinetic and pharmacodynamic properties of stimulants: implications for the design of new treatments for ADHD
2002 • 165 citations
Methylphenidate Dosage for Children With ADHD Over Time Under Controlled Conditions: Lessons From the MTA
2001 • 164 citations
Minimal Brain Dysfunction in Children.
1971 • 154 citations
Intravenous methylphenidate abuse. Prototype for prescription drug abuse.
1991 • 137 citations
Effects of Stimulant Medication on Learning in Children with ADHD
1991 • 129 citations
Functional consequences of acute cocaine treatment depend on route of administration
1993 • 120 citations
Blockade of striatal dopamine transporters by intravenous methylphenidate is not sufficient to induce self-reports of "high".
1999 • 120 citations
Timing, Space and ADHD: The Dopamine Theory Revisited
2001 • 111 citations
Sustained Release Methylphenidate: Pharmacokinetic Studies in ADDH Males
1989 • 98 citations
Methylphenidate bioavailability from two extended-release formulations
2002 • 78 citations
Acute Handling Stress Modulates Methylphenidate-induced Catecholamine Overflow in the Medial Prefrontal Cortex
2002 • 60 citations
The use of a laboratory school protocol to evaluate concepts about efficacy and side effects of new formulations of stimulant medications
2002 • 58 citations
Methylphenidate: Increased Abuse or Appropriate Use ?
1999 • 38 citations
Intravenous methylphenidate abuse. Prototype for prescription drug abuse
1991 • 34 citations