Cdo Functions at Multiple Points in the Sonic Hedgehog Pathway, and Cdo-Deficient Mice Accurately Model Human Holoprosencephaly

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

1996 • 3,041 citations

Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants

1997 • 1,695 citations

Activating Smoothened mutations in sporadic basal-cell carcinoma

1998 • 1,327 citations

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

2000 • 1,299 citations

1 Developmental roles and clinical significance of Hedgehog signaling

2003 • 896 citations

Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis

1995 • 886 citations

The Hedgehog Response Network: Sensors, Switches, and Routers

2004 • 821 citations

Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling

1999 • 703 citations

Identification of Hedgehog Pathway Components by RNAi in Drosophila Cultured Cells

2003 • 518 citations

Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling

2006 • 426 citations

The Cell Surface Membrane Proteins Cdo and Boc Are Components and Targets of the Hedgehog Signaling Pathway and Feedback Network in Mice

2006 • 383 citations

The Mutational Spectrum of the Sonic Hedgehog Gene in Holoprosencephaly: SHH Mutations Cause a Significant Proportion of Autosomal Dominant Holoprosencephaly

1999 • 353 citations

The role of Sonic hedgehog in normal and abnormal craniofacial morphogenesis

1999 • 338 citations

Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like features

2003 • 336 citations

Multiple Hits during Early Embryonic Development: Digenic Diseases and Holoprosencephaly

2002 • 307 citations

Coordinate regulation and synergistic actions of BMP4, SHH and FGF8 in the rostral prosencephalon regulate morphogenesis of the telencephalic and optic vesicles

2002 • 287 citations

Perspectives on holoprosencephaly: Part I. Epidemiology, genetics, and syndromology

1989 • 260 citations

Mutations in PATCHED-1, the receptor for SONIC HEDGEHOG, are associated with holoprosencephaly

2002 • 243 citations

Patterning of the embryonic forebrain

1998 • 221 citations

Teratogenesis of holoprosencephaly

2002 • 195 citations

Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation

2005 • 181 citations

Temporal perturbations in sonic hedgehog signaling elicit the spectrum of holoprosencephaly phenotypes

2004 • 178 citations

Protein Kinase C-δ and Mitogen-Activated Protein/Extracellular Signal–Regulated Kinase-1 Control GLI Activation in Hedgehog Signaling

2006 • 171 citations

Temporal perturbations in sonic hedgehog signaling elicit the spectrum of holoprosencephaly phenotypes

2004 • 157 citations

Gli1 is important for medulloblastoma formation in Ptc1+/− mice

2005 • 144 citations

BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation

2002 • 143 citations

Netrins and neogenin promote myotube formation

2004 • 140 citations

Cooperation between sonic hedgehog and fibroblast growth factor/MAPK signalling pathways in neocortical precursors

2004 • 135 citations

The mammalian twisted gastrulation gene functions in foregut and craniofacial development

2004 • 108 citations

Microform Holoprosencephaly in Mice that Lack the Ig Superfamily Member Cdon

2003 • 108 citations

NKX2 gene expression in neuroectoderm but not in mesendodermally derived structures depends on sonic hedgehog in mouse embryos

2000 • 92 citations

Positive Regulation of Myogenic bHLH Factors and Skeletal Muscle Development by the Cell Surface Receptor CDO

2004 • 92 citations

CDO, A Robo-related Cell Surface Protein that Mediates Myogenic Differentiation

1998 • 91 citations

Phenotypic variability in human embryonic holoprosencephaly in the Kyoto Collection

2004 • 90 citations

Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation

2003 • 77 citations

Developmental expression pattern of thecdo gene

2000 • 46 citations

Expression of the boc gene during murine embryogenesis

2002 • 43 citations