Loss of neurturin in frog—Comparative genomics study of GDNF family ligand-receptor pairs

A Simple, Fast, and Accurate Algorithm to Estimate Large Phylogenies by Maximum Likelihood

2003 • 16,546 citations

The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling

2005 • 7,000 citations

A General Empirical Model of Protein Evolution Derived from Multiple Protein Families Using a Maximum-Likelihood Approach

2001 • 2,762 citations

The GDNF family: Signalling, biological functions and therapeutic value

2002 • 1,722 citations

PHYML Online--a web server for fast maximum likelihood-based phylogenetic inference

2005 • 1,447 citations

An Evolutionary Trace Method Defines Binding Surfaces Common to Protein Families

1996 • 1,214 citations

ProbCons: Probabilistic consistency-based multiple sequence alignment

2005 • 1,139 citations

The origin of new genes: glimpses from the young and old

2003 • 911 citations

Über humorale übertragbarkeit der Herznervenwirkung

1921 • 817 citations

Genetic Analysis of the Mammalian Transforming Growth Factor-β Superfamily

2002 • 770 citations

Über humorale Übertragbarkeit der Herznervenwirkung

1924 • 473 citations

GDNF Family Neurotrophic Factor Signaling: Four Masters, One Servant?

1999 • 469 citations

The GDNF family ligands and receptors — implications for neural development

2000 • 464 citations

A common sex-dependent mutation in a RET enhancer underlies Hirschsprung disease risk

2005 • 460 citations

The GDNF/RET signaling pathway and human diseases

2001 • 432 citations

Retroposons—Seeds of Evolution

1991 • 372 citations

Central Control of the Cardiovascular and Respiratory Systems and Their Interactions in Vertebrates

1999 • 371 citations

Gene Targeting Reveals a Critical Role for Neurturin in the Development and Maintenance of Enteric, Sensory, and Parasympathetic Neurons

1999 • 326 citations

The RET receptor: function in development and dysfunction in congenital malformation

2001 • 286 citations

Retarded Growth and Deficits in the Enteric and Parasympathetic Nervous System in Mice Lacking GFRα2, a Functional Neurturin Receptor

1999 • 283 citations

The growth arrest-specific gene, gas1, is involved in growth suppression

1992 • 274 citations

Timing and mechanism of ancient vertebrate genome duplications – the adventure of a hypothesis

2005 • 226 citations

Receptors of the Glial Cell Line-Derived Neurotrophic Factor Family of Neurotrophic Factors Signal Cell Survival through the Phosphatidylinositol 3-Kinase Pathway in Spinal Cord Motoneurons

1999 • 173 citations

GFRα-4 and the tyrosine kinase Ret form a functional receptor complex for persephin

1998 • 156 citations

Distinct structural elements in GDNF mediate binding to GFRalpha 1 and activation of the GFRalpha 1-c-Ret receptor complex

1999 • 125 citations

Development of cranial parasympathetic ganglia requires sequential actions of GDNF and neurturin

2000 • 121 citations

Roles for GFRα1 receptors in zebrafish enteric nervous system development

2003 • 110 citations

Expression and Alternative Splicing of Mouse Gfra4 Suggest Roles in Endocrine Cell Development

2000 • 108 citations

Human Glial Cell Line-derived Neurotrophic Factor Receptor α4 Is the Receptor for Persephin and Is Predominantly Expressed in Normal and Malignant Thyroid Medullary Cells

2001 • 105 citations

GFRα-4, a New GDNF Family Receptor

1998 • 94 citations

Functional Analysis of Zebrafish GDNF

2001 • 82 citations

Alimentary tract innervation deficits and dysfunction in mice lacking GDNF family receptor α2

2003 • 77 citations

Deficient Nonpeptidergic Epidermis Innervation and Reduced Inflammatory Pain in Glial Cell Line-Derived Neurotrophic Factor Family Receptor α2 Knock-Out Mice

2006 • 75 citations

Structure of Artemin Complexed with Its Receptor GFRα3: Convergent Recognition of Glial Cell Line-Derived Neurotrophic Factors

2006 • 75 citations

Alimentary tract innervation deficits and dysfunction in mice lacking GDNF family receptor α2

2003 • 70 citations

GDNF and neurturin are target-derived factors essential for cranial parasympathetic neuron development

2001 • 69 citations

The structure of GFRα1 domain 3 reveals new insights into GDNF binding and RET activation

2004 • 67 citations

Determinants of Ligand Binding Specificity in the Glial Cell Line-derived Neurotrophic Factor Family Receptor αs

2001 • 65 citations

Functional Mapping of Receptor Specificity Domains of Glial Cell Line-derived Neurotrophic Factor (GDNF) Family Ligands and Production of GFRα1 RET-specific Agonists

2000 • 64 citations

Gas1 Is Related to the Glial Cell-derived Neurotrophic Factor Family Receptors α and Regulates Ret Signaling

2006 • 61 citations

Identification of a Surface for Binding to the GDNF-GFRα1 Complex in the First Cadherin-like Domain of RET

2003 • 58 citations

Neuroprotective Utility and Neurotrophic Action of Neurturin in Postnatal Motor Neurons: Comparison with GDNF and Persephin

1999 • 58 citations

Regulation of neural development by glial cell line-derived neurotrophic factor family ligands

2005 • 56 citations

Is GAS1 a co-receptor for the GDNF family of ligands?

2006 • 54 citations

Identification, expression and functional characterization of the GRAL gene

2005 • 52 citations

Expression pattern of Drosophila ret suggests a common ancestral origin between the metamorphosis precursors in insect endoderm and the vertebrate enteric neurons

2001 • 51 citations

Direct interactions among Ret, GDNF and GFRα1 molecules reveal new insights into the assembly of a functional three-protein complex

2004 • 49 citations

Distinct roles for GFRα1 and GFRα2 signalling in different cranial parasympathetic ganglia in vivo

2000 • 49 citations

ADDA: a domain database with global coverage of the protein universe

2004 • 48 citations

A Drosophila homolog of human proto-oncogene ret transiently expressed in embryonic neuronal precursor cells including neuroblasts and CNS cells

1994 • 45 citations

Ablation of Persephin Receptor Glial Cell Line-Derived Neurotrophic Factor Family Receptor α4 Impairs Thyroid Calcitonin Production in Young Mice

2006 • 43 citations

Differences and Developmental Changes in the Responsiveness of PNS Neurons to GDNF and Neurturin

1999 • 39 citations

GDNF increases the survival of developing oculomotor neurons through a target-derived mechanism

2003 • 32 citations

Analysis of the domain requirement in Gas1 growth suppressing activity

2000 • 31 citations

Multiple Actions of Neurturin Correlate with Spatiotemporal Patterns of Ret Expression in Developing Chick Cranial Ganglion Neurons

1999 • 25 citations

Growth and morphogenesis of an autonomic ganglion. I. Matching neurons with target.

1987 • 23 citations

Expression pattern of Drosophila ret suggests a common ancestral origin between the metamorphosis precursors in insect endoderm and the vertebrate enteric neurons

2001 • 13 citations

Cloning and characterization of the C. elegans gas1 homolog: phas-1

2002 • 12 citations