Olig gene function in CNS development and disease

Neuronal specification in the spinal cord: inductive signals and transcriptional codes

2000 • 2,051 citations

Multiple sclerosis

2002 • 1,678 citations

Common Developmental Requirement for Olig Function Indicates a Motor Neuron/Oligodendrocyte Connection

2002 • 1,024 citations

The bHLH Transcription Factors OLIG2 and OLIG1 Couple Neuronal and Glial Subtype Specification

2002 • 1,024 citations

Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination

2003 • 988 citations

A unified hypothesis on the lineage of neural stem cells

2001 • 976 citations

Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus

2000 • 967 citations

Premyelinating Oligodendrocytes in Chronic Lesions of Multiple Sclerosis

2002 • 941 citations

Neurobiology of Periventricular Leukomalacia in the Premature Infant

2001 • 929 citations

Multiple Sclerosis and Chronic Autoimmune Encephalomyelitis

2000 • 907 citations

Axonal Swellings and Degeneration in Mice Lacking the Major Proteolipid of Myelin

1998 • 870 citations

NG2-expressing glial progenitor cells: an abundant and widespread population of cycling cells in the adult rat CNS

2003 • 866 citations

Sonic Hedgehog–Regulated Oligodendrocyte Lineage Genes Encoding bHLH Proteins in the Mammalian Central Nervous System

2000 • 839 citations

Why does remyelination fail in multiple sclerosis?

2002 • 809 citations

Identification of a Novel Family of Oligodendrocyte Lineage-Specific Basic Helix–Loop–Helix Transcription Factors

2000 • 786 citations

NG2-Positive Oligodendrocyte Progenitor Cells in Adult Human Brain and Multiple Sclerosis Lesions

2000 • 686 citations

The oligodendrocyte precursor cell in health and disease

2001 • 654 citations

Coordinate Regulation of Motor Neuron Subtype Identity and Pan-Neuronal Properties by the bHLH Repressor Olig2

2001 • 614 citations

A niche for adult neural stem cells

2003 • 612 citations

Neuronal fate determinants of adult olfactory bulb neurogenesis

2005 • 602 citations

The bHLH Transcription Factor Olig2 Promotes Oligodendrocyte Differentiation in Collaboration with Nkx2.2

2001 • 586 citations

Axonal loss in the pathology of MS: consequences for understanding the progressive phase of the disease

2003 • 569 citations

Chronic Stage Multiple Sclerosis Lesions Contain a Relatively Quiescent Population of Oligodendrocyte Precursor Cells

1998 • 551 citations

Identification of an adult-specific glial progenitor cell

1989 • 476 citations

NG2 Is a Major Chondroitin Sulfate Proteoglycan Produced after Spinal Cord Injury and Is Expressed by Macrophages and Oligodendrocyte Progenitors

2002 • 474 citations

Combinatorial Roles of Olig2 and Neurogenin2 in the Coordinated Induction of Pan-Neuronal and Subtype-Specific Properties of Motoneurons

2001 • 431 citations

Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis

2004 • 419 citations

Glial specification in the vertebrate neural tube

2004 • 412 citations

Molecular mechanism for distinct neurological phenotypes conveyed by allelic truncating mutations

2004 • 410 citations

The Oligodendroglial Lineage Marker OLIG2 Is Universally Expressed in Diffuse Gliomas

2004 • 410 citations

bHLH Transcription Factor Olig1 Is Required to Repair Demyelinated Lesions in the CNS

2004 • 404 citations

Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3

2000 • 376 citations

Generation of Oligodendrocyte Precursor Cells from Mouse Dorsal Spinal Cord Independent of Nkx6 Regulation and Shh Signaling

2005 • 325 citations

Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia

2004 • 320 citations

Multiple Dorsoventral Origins of Oligodendrocyte Generation in the Spinal Cord and Hindbrain

2005 • 318 citations

Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice

1998 • 306 citations

Demyelination and remyelination of the caudal cerebellar peduncle of adult rats following stereotaxic injections of lysolecithin, ethidium bromide, and complement/anti-galactocerebroside: A comparative study

1999 • 304 citations

Patients lacking the major CNS myelin protein, proteolipid protein 1, develop length-dependent axonal degeneration in the absence of demyelination and inflammation

2002 • 291 citations

Activation of EGFP expression by Cre-mediated excision in a new ROSA26 reporter mouse strain

2001 • 288 citations

Glial-Restricted Precursors Are Derived from Multipotent Neuroepithelial Stem Cells

1997 • 287 citations

Increased expression of Nkx2.2 and Olig2 identifies reactive oligodendrocyte progenitor cells responding to demyelination in the adult CNS

2004 • 286 citations

Oligodendrocyte progenitors are present in the normal adult human CNS and in the lesions of multiple sclerosis

1998 • 285 citations

Regionalization and fate specification in neurospheres: the role of Olig2 and Pax6

2004 • 268 citations

Intrauterine infection and the development of cerebral palsy

2003 • 268 citations

Sonic hedgehog signaling is required during the appearance of spinal cord oligodendrocyte precursors

1999 • 266 citations

Different Levels of Repressor Activity Assign Redundant and Specific Roles to Nkx6 Genes in Motor Neuron and Interneuron Specification

2001 • 256 citations

A subset of oligodendrocytes generated from radial glia in the dorsal spinal cord

2005 • 254 citations

NG2-expressing cells in the subventricular zone are type C–like cells and contribute to interneuron generation in the postnatal hippocampus

2004 • 252 citations

Myelinogenesis and Axonal Recognition by Oligodendrocytes in Brain Are Uncoupled inOlig1-Null Mice

2005 • 242 citations

Multiple Cell Populations in the Early Postnatal Subventricular Zone Take Distinct Migratory Pathways: A Dynamic Study of Glial and Neuronal Progenitor Migration

2003 • 228 citations

Uncoupling of hypomyelination and glial cell death by a mutation in the proteolipid protein gene

1992 • 212 citations

Intrauterine infection and the development of cerebral palsy

2003 • 211 citations

Molecular diversity of astrocytes with implications for neurological disorders

2004 • 211 citations

Distinctive Patterns of PDGF-A, FGF-2, IGF-I, and TGF-β1 Gene Expression during Remyelination of Experimentally-Induced Spinal Cord Demyelination

1999 • 210 citations

The oligodendrocyte-type-2 astrocyte cell lineage is specialized for myelination

1986 • 201 citations

Synantocytes: new functions for novel NG2 expressing glia.

2002 • 200 citations

Development of NG2 neural progenitor cells requires Olig gene function

2006 • 196 citations

Emerging concepts in periventricular white matter injury

2004 • 192 citations

Light and electron microscopic localization of a cell surface antigen (NG2) in the rat cerebellum: association with smooth protoplasmic astrocytes

1987 • 188 citations

Endogenous Nkx2.2+/Olig2+ oligodendrocyte precursor cells fail to remyelinate the demyelinated adult rat spinal cord in the absence of astrocytes

2004 • 181 citations

An ‘oligarchy’ rules neural development

2002 • 176 citations

Myelin deficiencies in both the central and the peripheral nervous systems associated with aSOX10 mutation

1999 • 174 citations

Human oligodendroglial development: Relationship to periventricular leukomalacia

1998 • 173 citations

Neurological Phenotype in Waardenburg Syndrome Type 4 Correlates with Novel SOX10 Truncating Mutations and Expression in Developing Brain

2000 • 161 citations

Prognostic importance of TLX1 (HOX11) oncogene expression in adults with T-cell acute lymphoblastic leukaemia

2004 • 156 citations

Wnt signaling controls the timing of oligodendrocyte development in the spinal cord

2005 • 147 citations

Gliogenic and neurogenic progenitors of the subventricular zone: Who are they, where did they come from, and where are they going?

2003 • 143 citations

OLIG2 as a specific marker of oligodendroglial tumour cells

2001 • 140 citations

Focus on central nervous system neoplasia

2002 • 139 citations

Cracking the Transcriptional Code for Cell Specification in the Neural Tube

2001 • 135 citations

The Pathobiology of Myelin Mutants Reveal Novel Biological Functions of the MBP and PLP Genes

2001 • 133 citations

Distinct sites of origin of oligodendrocytes and somatic motoneurons in the chick spinal cord: oligodendrocytes arise from Nkx2.2-expressing progenitors by a Shh-dependent mechanism

2001 • 132 citations

Proteolipoprotein Gene Analysis in 82 Patients with Sporadic Pelizaeus-Merzbacher Disease: Duplications, the Major Cause of the Disease, Originate More Frequently in Male Germ Cells, but Point Mutations Do Not

1999 • 130 citations

Defining the NG2-expressing cell of the adult CNS.

2002 • 129 citations

FGF-dependent generation of oligodendrocytes by a hedgehog-independent pathway

2003 • 125 citations

Ectopic expression of Olig1 promotes oligodendrocyte formation and reduces neuronal survival in developing mouse cortex

2001 • 117 citations

Nuclear export of OLIG2 in neural stem cells is essential for ciliary neurotrophic factor–induced astrocyte differentiation

2004 • 112 citations

Ventral Neurogenesis and the Neuron-Glial Switch

2001 • 100 citations

Sonic Hedgehog Is Required during an Early Phase of Oligodendrocyte Development in Mammalian Brain

2001 • 85 citations

Physiological characteristics of NG2-expressing glial cells.

2002 • 82 citations

Expression of the Oligodendroglial Lineage-Associated Markers Olig1 and Olig2 in Different Types of Human Gliomas

2003 • 80 citations

Transient upregulation of Nkx2.2 expression in oligodendrocyte lineage cells during remyelination

2004 • 77 citations

Getting a GR(i)P on oligodendrocyte development

2003 • 77 citations

Converse control of oligodendrocyte and astrocyte lineage development by Sonic hedgehog in the chick spinal cord

2004 • 76 citations

Non-overlapping expression of Olig3 and Olig2 in the embryonic neural tube

2002 • 74 citations

Olig2 expression, GFAP, p53 and 1p loss analysis contribute to glioma subclassification

2004 • 70 citations

Cross-Repressive Interaction of the Olig2 and Nkx2.2 Transcription Factors in Developing Neural Tube Associated with Formation of a Specific Physical Complex

2003 • 69 citations

Evidence that perinatal and adult NG2-glia are not conventional oligodendrocyte progenitors and do not depend on axons for their survival

2003 • 63 citations

NG2 precursor cells in neoplasia: functional, histogenesis and therapeutic implications for malignant brain tumours.

2002 • 61 citations

Olig genes are expressed in a heterogeneous population of precursor cells in the developing spinal cord

2003 • 59 citations

Mouse NG2⁺Oligodendrocyte Precursors Express mRNA for Proteolipid Protein But Not Its DM-20 Variant: A Study of Laser Microdissection-Captured NG2⁺Cells

2003 • 47 citations

Neuro-oncology: the growing role of chemotherapy in glioma

2004 • 39 citations

Immunolocalization of the Oligodendrocyte Transcription Factor 1 (Olig1) in Brain Tumors

2004 • 36 citations

OLIG‐1 and 2 gene expression and oligodendroglial tumours

2002 • 24 citations

Remyelination by Endogenous Glia

2004 • 15 citations