Megalin Functions as an Endocytic Sonic Hedgehog Receptor

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

The zebrafish book : a guide for the laboratory use of zebrafish (Danio rerio)

1995 • 6,935 citations

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

1996 • 3,041 citations

Hedgehog signaling in animal development: paradigms and principles

2001 • 2,919 citations

Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development

1996 • 1,342 citations

Activating Smoothened mutations in sporadic basal-cell carcinoma

1998 • 1,327 citations

LDL-receptor-related proteins in Wnt signal transduction

2000 • 1,305 citations

Reeler/Disabled-like Disruption of Neuronal Migration in Knockout Mice Lacking the VLDL Receptor and ApoE Receptor 2

1999 • 1,231 citations

arrow encodes an LDL-receptor-related protein essential for Wingless signalling

2000 • 870 citations

Defective forebrain development in mice lacking gp330/megalin.

1996 • 485 citations

Skinny Hedgehog, an Acyltransferase Required for Palmitoylation and Activity of the Hedgehog Signal

2001 • 462 citations

An introduction to embryology

1965 • 429 citations

Argosomes

2001 • 413 citations

Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3

2000 • 394 citations

Hedgehog Movement Is Regulated through tout velu–Dependent Synthesis of a Heparan Sulfate Proteoglycan

1999 • 367 citations

Sonic hedgehogRegulates Proliferation and Inhibits Differentiation of CNS Precursor Cells

1999 • 360 citations

The Mutational Spectrum of the Sonic Hedgehog Gene in Holoprosencephaly: SHH Mutations Cause a Significant Proportion of Autosomal Dominant Holoprosencephaly

1999 • 353 citations

A novel mechanism for controlling the activity of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Multiple regulatory sites for 39-kDa receptor-associated protein.

1992 • 341 citations

The role of Sonic hedgehog in normal and abnormal craniofacial morphogenesis

1999 • 338 citations

Diverse roles for the LDL receptor family

2002 • 311 citations

Inhibition of Sonic hedgehog signaling in vivo results in craniofacial neural crest cell death

1999 • 289 citations

The Whereabouts of a Morphogen: Direct Evidence for Short- and Graded Long-Range Activity of Hedgehog Signaling Peptides

2001 • 288 citations

Zebrafishsmoothenedfunctions in ventral neural tube specification and axon tract formation

2001 • 287 citations

Local retinoid signaling coordinates forebrain and facial morphogenesis by maintaining FGF8 and SHH

2001 • 281 citations

Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog

1997 • 277 citations

Analysis of the zebrafishsmoothenedmutant reveals conserved and divergent functions of hedgehog activity

2001 • 266 citations

Sonic hedgehogParticipates in Craniofacial Morphogenesis and Is Down-regulated by Teratogenic Doses of Retinoic Acid

1997 • 258 citations

Platelet-derived Growth Factor (PDGF)-induced Tyrosine Phosphorylation of the Low Density Lipoprotein Receptor-related Protein (LRP)

2002 • 250 citations

An Introduction to Embryology

1953 • 243 citations

More Surprises in the Hedgehog Signaling Pathway

2000 • 219 citations

Platelet-derived Growth Factor Mediates Tyrosine Phosphorylation of the Cytoplasmic Domain of the Low Density Lipoprotein Receptor-related Protein in Caveolae

2002 • 216 citations

Interaction of Apolipoprotein J-Amyloid β-Peptide Complex with Low Density Lipoprotein Receptor-related Protein-2/Megalin

1997 • 197 citations

Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1

2000 • 195 citations

The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330.

1992 • 190 citations

Temporal and Spatial Effects of Sonic Hedgehog Signaling in Chick Eye Morphogenesis

2001 • 188 citations

The 39-kDa receptor-associated protein regulates ligand binding by the very low density lipoprotein receptor.

1994 • 177 citations

Sonic Hedgehog Control of Size and Shape in Midbrain Pattern Formation

2001 • 171 citations

LDL Receptor-Related Protein as a Component of the Midkine Receptor

2000 • 158 citations

The seven-transmembrane receptor Smoothened cell-autonomously induces multiple ventral cell types

2000 • 142 citations

Glycoprotein 330, a member of the low density lipoprotein receptor family, binds lipoprotein lipase in vitro

1993 • 124 citations

Plasminogen Activator Inhibitor-1 Contains a Cryptic High Affinity Binding Site for the Low Density Lipoprotein Receptor-related Protein

1998 • 124 citations

Anti-apoptotic role of Sonic hedgehog protein at the early stages of nervous system organogenesis

2001 • 112 citations

Glycoprotein 330/Low Density Lipoprotein Receptor-related Protein-2 Mediates Endocytosis of Low Density Lipoproteins via Interaction with Apolipoprotein B100

1995 • 103 citations

Functional antagonists of sonic hedgehog reveal the importance of the N terminus for activity

1999 • 98 citations

Immunological localization of glycoprotein 330, low density lipoprotein receptor related protein and 39 kDa receptor associated protein in embryonic mouse tissues.

1994 • 98 citations

Characterisation of a SecondpatchedGene in the ZebrafishDanio rerioand the Differential Response ofpatchedGenes to Hedgehog Signalling

1999 • 98 citations

Control of Shh activity and signaling in the neural tube

2000 • 92 citations

Transcytosis of Retinol-Binding Protein across Renal Proximal Tubule Cells after Megalin (gp 330)-Mediated Endocytosis

2001 • 81 citations

Receptor-associated protein (RAP): a specialized chaperone for endocytic receptors.

1998 • 78 citations

Immunolocalization of Sonic Hedgehog (Shh) in Developing Mouse Lung

2001 • 72 citations

gp330 on type ii pneumocytes mediates endocytosis leading to degradation of pro-urokinase, plasminogen activator inhibitor-1 and urokinase-plasminogen activator inhibitor-1 complex

1995 • 71 citations

An Overview of the Structure and Function of Glycoprotein 330, a Receptor Related to the α₂‐Macroglobulin Receptora

1994 • 45 citations

Transcellular Transport of Vitamin B12 in LLC-PK1 Renal Proximal Tubule Cells

2001 • 28 citations

Members of the low density lipoprotein receptor family control diverse physiological processes

2001 • 21 citations

Megalin-Mediated Transcytosis of Thyroglobulin by Thyroid Cells is a Calmodulin-Dependent Process

2000 • 21 citations