The stationary phase model of aging in yeast for the study of oxidative stress and age-related neurodegeneration

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

1991 • 6,550 citations

The Free Radical Theory of Aging Matures

1998 • 3,846 citations

Methods in Yeast Genetics: A Laboratory Course Manual

1990 • 1,922 citations

Methods in Yeast Genetics — A Laboratory Course Manual

1991 • 1,257 citations

Oxidative stress: the paradox of aerobic life

1995 • 1,152 citations

4-Hydroxy-2-nonenal: a product and mediator of oxidative stress

2003 • 1,119 citations

Bcl-2 family proteins

1998 • 1,055 citations

Regulation of Longevity and Stress Resistance by Sch9 in Yeast

2001 • 858 citations

Degradation of oxidized proteins by the 20S proteasome

2001 • 846 citations

Yeast Cells Provide Insight into Alpha-Synuclein Biology and Pathobiology

2003 • 790 citations

The Proteasome, a Novel Protease Regulated by Multiple Mechanisms

1999 • 540 citations

Superoxide Dismutase Activity Is Essential for Stationary Phase Survival in Saccharomyces cerevisiae

1996 • 522 citations

The Regulatory Particle of the Saccharomyces cerevisiae Proteasome

1998 • 487 citations

Role of oxidative stress and protein oxidation in the aging process1,2 1Guest Editor: Earl Stadtman 2This article is part of a series of reviews on “Oxidatively Modified Proteins in Aging and Disease.” The full list of papers may be found on the homepage of the journal.

2002 • 473 citations

Yeast Genes That Enhance the Toxicity of a Mutant Huntingtin Fragment or α-Synuclein

2003 • 427 citations

Repair of oxidative DNA damage in nuclear and mitochondrial DNA, and some changes with aging in mammalian cells1,2 1Guest Editor: Miral Dizdaroglu 2This article is part of a series of reviews on “Oxidative DNA Damage and Repair.” The full list of papers may be found on the homepage of the journal.

2002 • 368 citations

Aging: Overview

2001 • 366 citations

Oxidative stress and aging: beyond correlation

2002 • 335 citations

SOD2 Functions Downstream of Sch9 to Extend Longevity in Yeast

2003 • 327 citations

4-Hydroxy-2-nonenal-mediated Impairment of Intracellular Proteolysis during Oxidative Stress

1999 • 320 citations

Inhibition of the multicatalytic proteinase (proteasome) by 4‐hydroxy‐2‐nonenal cross‐linked protein

1997 • 264 citations

The proteasome in brain aging

2002 • 250 citations

Commentary the Measurement of Oxidative Damage to DNA by HPLC and GC/MS Techniques

1992 • 242 citations

Poly-ADP ribose polymerase activates nuclear proteasome to degrade oxidatively damaged histones

1999 • 228 citations

Longevity Regulation inSaccharomyces cerevisiae: Linking Metabolism, Genome Stability, and Heterochromatin

2003 • 227 citations

Rate of generation of oxidative stress-related damage and animal longevity

2002 • 226 citations

Human Bcl-2 Reverses Survival Defects in Yeast Lacking Superoxide Dismutase and Delays Death of Wild-Type Yeast

1997 • 203 citations

Interactions Among α-Synuclein, Dopamine, and Biomembranes: Some Clues for Understanding Neurodegeneration in Parkinson's Disease

2004 • 196 citations

Age-Related Changes in Protein Oxidation and Proteolysis in Mammalian Cells

2001 • 190 citations

AGING IN SACCHAROMYCES CEREVISIAE

1998 • 178 citations

Bcl-2 prevents mitochondrial permeability transition and cytochrome c release via maintenance of reduced pyridine nucleotides

2000 • 159 citations

Proteasomes: Structure and Biology

1998 • 158 citations

Visions & Reflections¶Regulation of longevity and stress resistance: a molecular strategy conserved from yeast to humans?

2002 • 146 citations

New insights into the mechanisms and importance of the proteasome in intracellular protein degradation.

1997 • 140 citations

Chronological lifespan of stationary phase yeast cells; a model for investigating the factors that might influence the ageing of postmitotic tissues in higher organisms

2001 • 139 citations

Impact of ageing on proteasome structure and function in human lymphocytes

2003 • 129 citations

Mutations in signal transduction proteins increase stress resistance and longevity in yeast, nematodes, fruit flies, and mammalian neuronal cells

1999 • 123 citations

Defects in the Ubiquitin Pathway Induce Caspase-independent Apoptosis Blocked by Bcl-2

1998 • 114 citations

Proteasomes and proteasome inhibition in the central nervous system

2001 • 114 citations

The budding yeast, Saccharomyces cerevisiae, as a model for aging research: a critical review

2000 • 113 citations

Breakdown of oxidized proteins as a part of secondary antioxidant defenses in mammalian cells

1997 • 95 citations

Role of the proteasome in protein oxidation and neural viability following low‐level oxidative stress

2003 • 91 citations

DNA repair comes of age

1995 • 74 citations

Bcl-2 family members inhibit oxidative stress-induced programmed cell death in Saccharomyces cerevisiae

2003 • 74 citations

Overproduction of Cu/Zn-Superoxide Dismutase or Bcl-2 Prevents the Brain Mitochondrial Respiratory Dysfunction Induced by Glutathione Depletion

1999 • 67 citations

Proteasomal degradation of oxidatively damaged endogenous histones in K562 human leukemic cells

2001 • 63 citations

Mechanisms of Bcl-2 protein function.

1998 • 62 citations

Review: To bud until death: The genetics of ageing in the yeast, Saccharomyces

1996 • 59 citations

Peroxynitrite-induced oxidation and its effects on isolated proteasomal systems

2003 • 55 citations

Mutants in theSaccharomyces cerevisiae RAS2gene influence life span, cytoskeleton, and regulation of mitosis

1997 • 54 citations

Role ofRAS2in Recovery from Chronic Stress: Effect on Yeast Life Span

1998 • 50 citations

Proteasome synthesis and assembly are required for survival during stationary phase

2004 • 47 citations

Base excision repair activities required for yeast to attain a full chronological life span

2003 • 42 citations

Genomic Heterogeneity of DNA Repair

1992 • 40 citations

The 20S Proteasome

2002 • 28 citations

The 26S Proteasome

2002 • 27 citations

A Single Gene Change Can Extend Yeast Life Span: The Role of RAS in Cellular Senescence

1993 • 14 citations