Role of the proteasome in protein oxidation and neural viability following low‐level oxidative stress

The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction

2002 • 4,069 citations

Protein Oxidation in Aging, Disease, and Oxidative Stress

1997 • 3,299 citations

Reactive Oxygen Species and the Central Nervous System

1992 • 2,931 citations

Oxidative Stress Hypothesis in Alzheimer's Disease

1997 • 2,355 citations

The 26S Proteasome: A Molecular Machine Designed for Controlled Proteolysis

1999 • 1,872 citations

Role of Free Radicals in the Neurodegenerative Diseases

2001 • 1,490 citations

Oxidative stress: the paradox of aerobic life

1995 • 1,152 citations

Mitochondrial Manganese Superoxide Dismutase Prevents Neural Apoptosis and Reduces Ischemic Brain Injury: Suppression of Peroxynitrite Production, Lipid Peroxidation, and Mitochondrial Dysfunction

1998 • 874 citations

Degradation of oxidized proteins by the 20S proteasome

2001 • 846 citations

Impaired Proteasome Function in Alzheimer's Disease

2000 • 795 citations

Proteasomal function is impaired in substantia nigra in Parkinson's disease

2001 • 631 citations

Antigen processing by the proteasome

2001 • 620 citations

p53-dependent Induction of Apoptosis by Proteasome Inhibitors

1997 • 473 citations

Altered peptidase and viral-specific T cell response in LMP2 mutant mice

1994 • 450 citations

Brain protein oxidation in age-related neurodegenerative disorders that are associated with aggregated proteins

2001 • 425 citations

Proteasome inhibition causes nigral degeneration with inclusion bodies in rats

2002 • 264 citations

The proteasome in brain aging

2002 • 250 citations

Proteasome Inhibitors Induce Cytochrome c–Caspase-3-Like Protease-Mediated Apoptosis in Cultured Cortical Neurons

2000 • 230 citations

Aggresomes and Russell bodies

2000 • 229 citations

Defective ubiquitination of cerebral proteins in Alzheimer's disease

2000 • 216 citations

Proteasome inhibition in oxidative stress neurotoxicity: implications for heat shock proteins

2001 • 178 citations

Elevated oxidative stress in models of normal brain aging and Alzheimer's disease

1999 • 148 citations

Interferon-γ inducible exchanges of 20S proteasome active site subunits: Why?

2001 • 145 citations

New insights into the mechanisms and importance of the proteasome in intracellular protein degradation.

1997 • 140 citations

Polyglutamine Expansion, Protein Aggregation, Proteasome Activity, and Neural Survival

2002 • 117 citations

Proteasomes and proteasome inhibition in the central nervous system

2001 • 114 citations

LMP2+ proteasomes are required for the presentation of specific antigens to cytotoxic T lymphocytes

1995 • 97 citations

Lactacystin, a specific inhibitor of the proteasome, induces apoptosis and activates caspase-3 in cultured cerebellar granule cells

2000 • 86 citations

Increased Protein Oxidation and Decreased Creatine Kinase BB Expression and Activity after Spinal Cord Contusion Injury

2002 • 76 citations

Vulnerability of Synaptosomes from ApoE Knock-Out Mice to Structural and Oxidative Modifications Induced by Aβ(1−40): Implications for Alzheimer's Disease

2001 • 63 citations

Structural Plasticity of the Proteasome and Its Function in Antigen Processing

2001 • 54 citations

Proteasome inhibition results in increased poly-ADP-ribosylation: Implications for neuron death

2000 • 53 citations

Rapid Isolation and Characterization of the Yeast Proteasome Regulatory Complex

2000 • 46 citations

Immunological Functions of the Proteasome

2002 • 43 citations

Lysophosphatidic acid and apoptosis of nerve growth factor-differentiated PC12 cells

1998 • 39 citations

Natural Substrates of the Proteasome and Their Recognition by the Ubiquitin System

2002 • 32 citations

Regulating the 26S Proteasome

2002 • 30 citations

The 20S Proteasome

2002 • 28 citations

Analysis of Werner’s expression within the brain and primary neuronal culture

2002 • 15 citations

Changes in activity and expression of phosphofructokinase in different rat brain regions after basal forebrain cholinergic lesion

2002 • 13 citations