Aging: Overview

Aging: A Theory Based on Free Radical and Radiation Chemistry

1956 • 8,252 citations

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

Aging, Natural Death, and the Compression of Morbidity

1980 • 3,304 citations

Oxidative Stress, Caloric Restriction, and Aging

1996 • 3,136 citations

Protein Oxidation and Aging

1992 • 2,687 citations

The Biologic Clock: The Mitochondria?

1972 • 1,912 citations

The aging process.

1981 • 1,871 citations

The p66shc adaptor protein controls oxidative stress response and life span in mammals

1999 • 1,688 citations

Extension of Life-Span by Overexpression of Superoxide Dismutase and Catalase in Drosophila melanogaster

1994 • 1,461 citations

IRON AND THE SEX DIFFERENCE IN HEART DISEASE RISK

1981 • 962 citations

Birth Weight and Adult Hypertension, Diabetes Mellitus, and Obesity in US Men

1996 • 930 citations

Mitochondrial role in cell aging

1980 • 919 citations

Glutathione-ascorbic acid antioxidant system in animals

1994 • 825 citations

Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse

1994 • 785 citations

Does superoxide underlie the pathogenesis of hypertension?

1991 • 760 citations

Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.

1991 • 734 citations

Carboxyfullerenes as neuroprotective agents

1997 • 724 citations

In Search of Methuselah: Estimating the Upper Limits to Human Longevity

1990 • 623 citations

Life Span Study of SPF Fischer 344 Male Rats Fed AdLibitum or Restricted Diets: Longevity, Growth, Lean Body Mass and Disease

1982 • 573 citations

Coenzyme Q ₁₀ administration increases brain mitochondrial concentrations and exerts neuroprotective effects

1998 • 546 citations

A Nonpeptidyl Mimic of Superoxide Dismutase with Therapeutic Activity in Rats

1999 • 502 citations

Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species

1993 • 484 citations

Hypothesis: does breast cancer originate in utero?

1990 • 472 citations

Biologically active metal-independent superoxide dismutase mimics

1990 • 427 citations

Free Radical Theory of Aging: Effect of Free Radical Reaction Inhibitors on the Mortality Rate of Male LAF1 Mice

1968 • 339 citations

α-Lipoic Acid in Liver Metabolism and Disease

1998 • 337 citations

Mitochondrial glutathione oxidation correlates with age‐associated oxidative damage to mitochondrial DNA

1996 • 305 citations

(R)‐α‐Lipoic acid‐supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate

1999 • 297 citations

Hydrogen peroxide release by mitochondria increases during aging

1991 • 292 citations

Acetyl- <scp>l</scp> -carnitine fed to old rats partially restores mitochondrial function and ambulatory activity

1998 • 264 citations

Low Mitochondrial Free Radical Production Per Unit O₂Consumption Can Explain the Simultaneous Presence of High Longevity and High Aerobic Metabolic Rate in Birds

1994 • 260 citations

A maternal diet high in n − 6 polyunsaturated fats alters mammary gland development, puberty onset, and breast cancer risk among female rat offspring

1997 • 255 citations

Intrauterine Environment and Breast Cancer Risk in Women: A Population-Based Study

1997 • 243 citations

Is Cell Aging Caused by Respiration-Dependent Injury to the Mitochondrial Genome?

1982 • 242 citations

Free radical theory of aging: Consequences of mitochondrial aging

1983 • 239 citations

Comparison of mitochondrial pro-oxidant generation and anti-oxidant defenses between rat and pigeon: possible basis of variation in longevity and metabolic potential

1993 • 234 citations

Genotoxic effects of estrogens

1990 • 227 citations

Free Radical Involvement in Aging

1993 • 226 citations

Dietary Restriction and Aging: The Initiation of a Primate Study

1990 • 220 citations

A Critical Review of Spin Trapping in Biological Systems

1980 • 212 citations

A Ginkgo Biloba Extract (EGb 761) Prevents Mitochondrial Aging by Protecting Against Oxidative Stress

1998 • 212 citations

Covalent modification reactions are marking steps in protein turnover

1990 • 211 citations

Free radical theory of aging: The “free radical” diseases

1984 • 192 citations

The toxicologic and pharmacologic properties of amantadine hydrochloride

1969 • 181 citations

Aging: Phenomena and Theories

1998 • 150 citations

Resolution of NADH:ubiquinone oxidoreductase from bovine heart mitochondria into two subcomplexes, one of which contains the redox centers of the enzyme

1992 • 142 citations

Lipid peroxidation and changes in the ubiquinone content and the respiratory chain enzymes of submitochondrial particles

1997 • 141 citations

Effect of Ethoxyquin on the Longevity of C3H Mice

1971 • 129 citations

Oxidative Stress and Advancing Age: Results in Healthy Centenarians

1998 • 129 citations

Biochemical Correlates of Longevity in Two Closely Related Rodent Species

1993 • 115 citations

Oxidative Damage to Behavior During Aging

1991 • 112 citations

The Spin-Trap N-tert-α-Phenylbutylnitrone Prolongs the Life Span of the Senescence-Accelerated Mouse

1995 • 110 citations

Surface localization of sites of reduction of nitroxide spin-labeled molecules in mitochondria.

1977 • 106 citations

Mode of Action of the Antiviral Activity of Amantadine in Tissue Culture

1965 • 106 citations

Mitochondrial involvement in schizophrenia and other functional psychoses

1996 • 104 citations

Aging: Prospects for further increases in the functional life span

1994 • 103 citations

Age-associated changes in superoxide dismutase activity, thiobarbituric acid reactivity and reduced glutathione level in the brain and liver in senescence accelerated mice (SAM): a comparison with ddY mice

1993 • 102 citations

Free radical theory of aging: History

1992 • 102 citations

Effect of dietary 2-mercaptoethanol on the life span, immune system, tumor incidence and lipid peroxidation damage in spleen lymphocytes of aging BC3F1 mice

1984 • 101 citations

Superoxide, neuroleptics and the ubiquinone and cytochrome b5 reductases in brain and lymphocytes from normals and schizophrenic patients

1998 • 93 citations

Antioxidant treatment with phenyl-α-tert-butyl nitrone (PBN) improves the cognitive performance and survival of aging rats

1996 • 89 citations

Favorable effects of the antioxidants sodium and magnesium thiazolidine carboxylate on the vitality and life span of Drosophila and mice

1979 • 80 citations

Free radical theory of aging: Nutritional implications

1978 • 76 citations

Free radicals and the action of inhibitors of radical processes under pathological states and ageing in living organisms and in man

1976 • 70 citations

The Search for the Genetic Basis of Aging: The Identification of Gerontogenes in the Nematode Caenorhabditis elegans

1992 • 67 citations

A Spin Trap, N-tert-Butyl-α-phenylnitrone Extends the Life Span of Mice

1998 • 64 citations

An electron paramagnetic resonance study of the antioxidant properties of the nitroxide free radical tempo

1993 • 58 citations

Genetically determined conidial longevity is positively correlated with superoxide dismutase, catalase, glutathione peroxidase, cytochrome c peroxidase, and ascorbate free radical reductase activities in Neurospora crassa

1984 • 50 citations

Free radical theory of aging: Beneficial effect of adding antioxidants to the maternal mouse diet on life span of offspring; possible explanation of the sex difference in longevity

1979 • 48 citations

Buckyballs: Wide Open Playing Field for Chemists

1991 • 40 citations

Studies of mitochondria in oxidative embryotoxicity

1995 • 37 citations

A pilot double-blind study of sodium-magnesium EDTA in peripheral vascular disease.

1990 • 36 citations

Protective effect of vitamin E on fetal distress induced by ischemia of the uteroplacental system in pregnant rats

1990 • 29 citations

Aging: Minimizing Free Radical Damage

1999 • 25 citations

High oestrogen excretion in pregnancy

1982 • 23 citations

Aminoethylcysteine Ketimine-Decarboxylated Dimer Protects Submitochondrial Particles from Lipid Peroxidation at a Concentration Not Inhibitory of Electron Transport

1994 • 15 citations

Antioxidant therapy in the aging process

1992 • 12 citations