The budding yeast, Saccharomyces cerevisiae, as a model for aging research: a critical review

The limited in vitro lifetime of human diploid cell strains

1965 • 5,595 citations

Life with 6000 Genes

1996 • 4,125 citations

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

2000 • 3,355 citations

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

1999 • 2,199 citations

Methods in Yeast Genetics: A Laboratory Course Manual

1990 • 1,922 citations

The Transcriptional Program of Sporulation in Budding Yeast

1998 • 1,876 citations

HIF-1: mediator of physiological and pathophysiological responses to hypoxia

2000 • 1,769 citations

Extrachromosomal rDNA Circles— A Cause of Aging in Yeast

1997 • 1,477 citations

Hsp104, Hsp70, and Hsp40

1998 • 1,346 citations

Methods in Yeast Genetics — A Laboratory Course Manual

1991 • 1,257 citations

Handbook of the Biology of Aging

1990 • 1,219 citations

In yeast, RAS proteins are controlling elements of adenylate cyclase

1985 • 1,142 citations

Molecular Biology of Aging

1999 • 877 citations

Life Span of Individual Yeast Cells

1959 • 754 citations

Sir2 links chromatin silencing, metabolism, and aging

2000 • 725 citations

Stationary phase in the yeast Saccharomyces cerevisiae

1993 • 594 citations

GENEALOGY OF PRINCIPAL STRAINS OF THE YEAST GENETIC STOCK CENTER

1986 • 587 citations

Relationship between donor age and the replicative lifespan of human cells in culture: A reevaluation

1998 • 547 citations

Mutation in the silencing gene S/R4 can delay aging in S. cerevisiae

1995 • 496 citations

Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals

1998 • 395 citations

At the heart of the budding yeast cell cycle

1996 • 367 citations

Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life span.

1994 • 309 citations

Stationary phase in Saccharomyces cerevisiae

1996 • 235 citations

Heat-shock protein 104 expression is sufficient for thermotolerance in yeast.

1996 • 223 citations

Evidence for the involvement of a cytoplasmic factor in the aging of the yeast Saccharomyces cerevisiae

1989 • 211 citations

Modulation of Life-span by Histone Deacetylase Genes inSaccharomyces cerevisiae

1999 • 206 citations

Human Bcl-2 Reverses Survival Defects in Yeast Lacking Superoxide Dismutase and Delays Death of Wild-Type Yeast

1997 • 203 citations

Divergent roles of RAS1 and RAS2 in yeast longevity

1994 • 191 citations

Crosstalk between the Ras2p-controlled Mitogen-activated Protein Kinase and cAMP Pathways during Invasive Growth ofSaccharomyces cerevisiae

1999 • 174 citations

Oxidative stress during aging of stationary cultures of the yeast Saccharomyces cerevisiae

2000 • 172 citations

Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae

1999 • 158 citations

Effects of Mutations in DNA Repair Genes on Formation of Ribosomal DNA Circles and Life Span in Saccharomyces cerevisiae

1999 • 153 citations

Methods in Aging Research

1998 • 149 citations

Characterization of a human gene with sequence homology to Saccharomyces cerevisiae SIR2

1999 • 130 citations

Regulation of fermentative capacity and levels of glycolytic enzymes in chemostat cultures of Saccharomyces cerevisiae

2000 • 125 citations

Mutations in signal transduction proteins increase stress resistance and longevity in yeast, nematodes, fruit flies, and mammalian neuronal cells

1999 • 123 citations

Yeast spore germination: a requirement for Ras protein activity during re-entry into the cell cycle

1997 • 120 citations

Molecular mechanisms of yeast aging

1998 • 117 citations

The Highly Conserved, Coregulated SNO and SNZ Gene Families in Saccharomyces cerevisiae Respond to Nutrient Limitation

1998 • 113 citations

The function of hypoxia‐inducible factor 1 (HIF‐1) is impaired in senescent mice

1999 • 109 citations

Replicative ageing in the fission yeastSchizosaccharomyces pombe

1999 • 107 citations

Aquaporins in Saccharomyces

1998 • 102 citations

Glucose induces cAMP-independent growth-related changes in stationary-phase cells of Saccharomyces cerevisiae.

1991 • 100 citations

Telomere length constancy during aging of Saccharomyces cerevisiae

1991 • 96 citations

Meiotic Recombination in Yeast: Coronation of the Double-Strand-Break Repair Model

1996 • 93 citations

Handbook of the Biology of Aging

2021 • 85 citations

Cell Division Regulation by BIR1, a Member of the Inhibitor of Apoptosis Family in Yeast

2000 • 83 citations

Folding in vivo of a newly translated yeast cytosolic enzyme is mediated by the SSA class of cytosolic yeast Hsp70 proteins

1998 • 82 citations

Molecular mechanisms of yeast longevity

1999 • 80 citations

Polarity in Cell Division

2000 • 79 citations

Two paralogs involved in transcriptional silencing that antagonistically control yeast life span

2000 • 78 citations

Glucose starvation induces a drastic reduction in the rates of both transcription and degradation of mRNA in yeast

2000 • 77 citations

Methods in Aging Research

1998 • 74 citations

An Experimental System for the Molecular Analysis of the Aging Process: The Budding Yeast Saccharomyces Cerevisiae

1990 • 58 citations

The Molecular Genetics of Aging

2000 • 56 citations

Changes of telomere length cause reciprocal changes in the lifespan of mother cells in Saccharomyces cerevisiae

1997 • 53 citations

Fermenting debate: do yeast undergo apoptosis?

1998 • 45 citations

The RAS genes: a homeostatic device in Saccharomyces cerevisiae longevity☆

1999 • 43 citations

Death-Defying Yeast Identify Novel Apoptosis Genes

1998 • 38 citations

Paradigms in aging research: a critical review and assessment

2000 • 30 citations

Role of Transcription Factors in the Age-Dependent Regulation of the Androgen Receptor Gene in Rat Liver

1996 • 29 citations

Vicious circles: a mechanism for yeast aging

1998 • 27 citations

The ins and outs of cell-polarity decisions

2000 • 25 citations

A general model of yeast energy metabolism in aerobic chemostat culture

1994 • 21 citations

Experimentation with the Yeast Model

1998 • 19 citations

Coordination of Metabolic Activity and Stress Resistance in Yeast Longevity

2000 • 14 citations

Effects of Aging and Physical Training on the Neuromuscular Junction of the Mouse

1987 • 14 citations

Yeast aging research: recent advances and medical relevance

1999 • 7 citations

The N-end rule pathway is required for import of histidine in yeast lacking the kinesin-like protein Cin8p

1999 • 4 citations