Base excision repair activities required for yeast to attain a full chronological life span

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1994 • 1,435 citations

Regulation of Longevity and Stress Resistance by Sch9 in Yeast

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1998 • 852 citations

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Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals

2000 • 536 citations

The base excision repair pathway

1995 • 536 citations

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1996 • 499 citations

FLP Recombinase-Mediated Induction of Cu/Zn-Superoxide Dismutase Transgene Expression Can Extend the Life Span of Adult Drosophila melanogaster Flies

1999 • 462 citations

Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis.

1993 • 437 citations

Stress signaling in yeast

1995 • 415 citations

Cloning and sequencing a human homolog (hMYH) of the Escherichia coli mutY gene whose function is required for the repair of oxidative DNA damage

1996 • 386 citations

Induced Overexpression of Mitochondrial Mn-Superoxide Dismutase Extends the Life Span of Adult Drosophila melanogaster

2002 • 374 citations

Cloning and expression in Escherichia coli of the OGG1 gene of Saccharomyces cerevisiae, which codes for a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine.

1996 • 352 citations

Opposite base-dependent reactions of a human base excision repair enzyme on DNA containing 7,8-dihydro-8-oxoguanine and abasic sites

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1992 • 295 citations

Unified catalytic mechanism for DNA glycosylases

1994 • 266 citations

Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III

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1999 • 244 citations

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1994 • 239 citations

Yeast and mammalian metallothioneins functionally substitute for yeast copper-zinc superoxide dismutase.

1993 • 230 citations

Inactivation of OGG1 increases the incidence of G · C→T · A transversions in Saccharomyces cerevisiae : evidence for endogenous oxidative damage to DNA in eukaryotic cells

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Cellular role of yeast Apn1 apurinic endonuclease/3'-diesterase: repair of oxidative and alkylation DNA damage and control of spontaneous mutation.

1991 • 211 citations

Stress, DNA damage and ageing — an integrative approach

2001 • 202 citations

Identification of APN2, the Saccharomyces cerevisiae homolog of the major human AP endonuclease HAP1, and its role in the repair of abasic sites

1998 • 201 citations

Yeast structural gene (APN1) for the major apurinic endonuclease: homology to Escherichia coli endonuclease IV.

1990 • 199 citations

Evidence for two DNA repair enzymes for 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in human cells.

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Release of normal bases from intact DNA by a native DNA repair enzyme

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Calendar life span versus budding lifespan of Saccharomyces cerevisiae

1980 • 173 citations

Base excision of oxidative purine and pyrimidine DNA damage in Saccharomyces cerevisiae by a DNA glycosylase with sequence similarity to endonuclease III from Escherichia coli.

1996 • 153 citations

Cloning and Expression of the cDNA Encoding the Human Homologue of the DNA Repair Enzyme, Escherichia coli Endonuclease III

1997 • 147 citations

The Saccharomyces cerevisiae Homologues of Endonuclease III from Escherichia coli, Ntg1 and Ntg2, Are Both Required for Efficient Repair of Spontaneous and Induced Oxidative DNA Damage in Yeast

1999 • 147 citations

Yeast superoxide dismutase mutants reveal a pro-oxidant action of weak organic acid food preservatives

1999 • 141 citations

Chronological lifespan of stationary phase yeast cells; a model for investigating the factors that might influence the ageing of postmitotic tissues in higher organisms

2001 • 139 citations

Yeast Lacking Superoxide Dismutase(s) Show Elevated Levels of “Free Iron” as Measured by Whole Cell Electron Paramagnetic Resonance

2000 • 134 citations

Molecular mechanisms of yeast aging

1998 • 117 citations

Saccharomyces cerevisiae Ntg1p and Ntg2p: Broad Specificity N-Glycosylases for the Repair of Oxidative DNA Damage in the Nucleus and Mitochondria

1999 • 115 citations

Second human protein with homology to theEscherichia coli abasic endonuclease exonuclease III

2000 • 113 citations

Transgenic methods for increasing Drosophila life span

2000 • 106 citations

Pir1p Mediates Translocation of the Yeast Apn1p Endonuclease into the Mitochondria To Maintain Genomic Stability

2001 • 105 citations

Mitochondrial DNA rearrangements in aging human brain and in situ PCR of mtDNA

1999 • 101 citations

DNA Repair and the Evolution of Longevity: A Critical Analysis

1994 • 99 citations

Substrate specificities of the Ntg1 and Ntg2 proteins of Saccharomyces cerevisiae for oxidized DNA bases are not identical

1998 • 97 citations

The plasma membrane of yeast acquires a novel heat‐shock protein (hsp30) and displays a decline in proton‐pumping ATPase levels in response to both heat shock and the entry to stationary phase

1992 • 96 citations

Repair of oxidized DNA bases in the yeast Saccharomyces cerevisiae

1997 • 95 citations

The mechanism of switching among multiple BER pathways

2001 • 93 citations

Cloning and expression in Escherichia coli of a gene for an alkylbase DNA glycosylase from Saccharomyces cerevisiae; a homologue to the bacterial alkA gene.

1990 • 84 citations

Evidence for the Involvement of Nucleotide Excision Repair in the Removal of Abasic Sites in Yeast

2000 • 84 citations

Apurinic Endonuclease Activity of Yeast Apn2 Protein

2000 • 73 citations

3′-Phosphodiesterase and 3′→5′ Exonuclease Activities of Yeast Apn2 Protein and Requirement of These Activities for Repair of Oxidative DNA Damage

2001 • 71 citations

Synergism between base excision repair, mediated by the DNA glycosylases Ntg1 and Ntg2, and nucleotide excision repair in the removal of oxidatively damaged DNA bases in Saccharomyces cerevisiae

2001 • 71 citations

Yeast gene analysis

1998 • 69 citations

The apurinic-apyrimidinic endonuclease IV family of DNA repair enzymes.

1997 • 60 citations

Yeast base excision repair: Interconnections and networks

2001 • 47 citations

Purification and Properties of the Alkylation Repair DNA Glycosylase Encoded by the MAG Gene from Saccharomyces cerevisiae

1995 • 46 citations

Human premature aging syndromes and genomic instability

2002 • 34 citations

Normal processing of AP sites in Apn1‐deficient Saccharomyces cerevisiae is restored by Escherichia coli genes expressing either exonuclease III or endonuclease III

1997 • 27 citations

The apurinic–apyrimidinic endonuclease IV family of DNA repair enzymes

1997 • 7 citations