Visions & Reflections¶Regulation of longevity and stress resistance: a molecular strategy conserved from yeast to humans?

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1956 • 8,252 citations

A C. elegans mutant that lives twice as long as wild type

1993 • 3,250 citations

Oxidative Stress, Caloric Restriction, and Aging

1996 • 3,136 citations

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

1999 • 2,199 citations

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

1997 • 2,174 citations

Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiae

2000 • 1,756 citations

The p66shc adaptor protein controls oxidative stress response and life span in mammals

1999 • 1,688 citations

A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function

2001 • 1,583 citations

Effects of Human Growth Hormone in Men over 60 Years Old

1990 • 1,560 citations

daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans

1997 • 1,468 citations

Extension of Life-Span by Overexpression of Superoxide Dismutase and Catalase in Drosophila melanogaster

1994 • 1,461 citations

Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

2001 • 1,398 citations

Genetic pathways that regulate ageing in model organisms

2000 • 1,341 citations

The Regulation and Activities of the Multifunctional Serine/Threonine Kinase Akt/PKB

1999 • 882 citations

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

1996 • 870 citations

Regulation of Longevity and Stress Resistance by Sch9 in Yeast

2001 • 858 citations

Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons

1998 • 852 citations

Extended Life-Span and Stress Resistance in the Drosophila Mutant methuselah

1998 • 815 citations

Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production

2001 • 814 citations

Reserve carbohydrate metabolism in Saccharomyces cerevisiae: responses to nutrient limitation

1980 • 807 citations

Life Span of Individual Yeast Cells

1959 • 754 citations

Thedaf‐2gene network for longevity regulates oxidative stress resistance and Mn‐superoxide dismutase gene expression inCaenorhabditis elegans

1999 • 721 citations

Aging and resistance to oxidative damage in Caenorhabditis elegans.

1993 • 720 citations

Novel sensing mechanisms and targets for the cAMP–protein kinase A pathway in the yeast Saccharomyces cerevisiae

1999 • 660 citations

Stationary phase in the yeast Saccharomyces cerevisiae

1993 • 594 citations

A Conserved Regulatory System for Aging

2001 • 526 citations

Superoxide Dismutase Activity Is Essential for Stationary Phase Survival in Saccharomyces cerevisiae

1996 • 522 citations

The biology of replicative senescence

1997 • 511 citations

FLP Recombinase-Mediated Induction of Cu/Zn-Superoxide Dismutase Transgene Expression Can Extend the Life Span of Adult Drosophila melanogaster Flies

1999 • 462 citations

The Genetics of Aging

2001 • 445 citations

A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans

1999 • 421 citations

Increased Life-Span of age -1 Mutants in Caenorhabditis elegans and Lower Gompertz Rate of Aging

1990 • 402 citations

Longevity, Genes, and Aging

1996 • 352 citations

Msn2p and Msn4p Control a Large Number of Genes Induced at the Diauxic Transition Which Are Repressed by Cyclic AMP in Saccharomyces cerevisiae

1998 • 269 citations

Ca2+-Dependent Routes to Ras: Mechanisms for Neuronal Survival, Differentiation, and Plasticity?

1996 • 262 citations

Stationary phase in Saccharomyces cerevisiae

1996 • 235 citations

Human Bcl-2 Reverses Survival Defects in Yeast Lacking Superoxide Dismutase and Delays Death of Wild-Type Yeast

1997 • 203 citations

AGING IN SACCHAROMYCES CEREVISIAE

1998 • 178 citations

Catalase expression in delayed and premature aging mouse models☆

2000 • 172 citations

Mutations in signal transduction proteins increase stress resistance and longevity in yeast, nematodes, fruit flies, and mammalian neuronal cells

1999 • 123 citations

Effects of Growth Hormone and Insulin-Like Growth Factor-1 on Hepatocyte Antioxidative Enzymes

2002 • 112 citations

Diverse Caenorhabditis elegans genes that are upregulated in dauer larvae also show elevated transcript levels in long-lived, aged, or starved adults

2000 • 90 citations

Evolutionary mechanisms of senescence

1993 • 73 citations

Neurotrophic factors influence upregulation of constitutive isoform of heme oxygenase and cellular stress response in the spinal cord following trauma. An experimental study using immunohistochemistry in the rat.

2000 • 50 citations

Action and interaction of growth hormone and the β-agonist, clenbuterol, on growth, body composition and protein turnover in dwarf mice

1991 • 44 citations