Bcl-2 prevents mitochondrial permeability transition and cytochrome c release via maintenance of reduced pyridine nucleotides

Mitochondria and Apoptosis

1998 • 8,909 citations

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 • 5,359 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

The mitochondrial permeability transition

1995 • 2,412 citations

THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS

1998 • 1,982 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

Bax directly induces release of cytochrome c from isolated mitochondria

1998 • 1,514 citations

The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy

1998 • 1,381 citations

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

1996 • 1,143 citations

Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c

1998 • 872 citations

Safranine as a probe of the mitochondrial membrane potential

1976 • 786 citations

Superoxide in Apoptosis

1998 • 773 citations

Mitochondrial control of apoptosis: the role of cytochrome c

1998 • 751 citations

The Permeability Transition Pore Complex: A Target for Apoptosis Regulation by Caspases and Bcl-2–related Proteins

1998 • 700 citations

Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury

1997 • 422 citations

The permeability transition pore. Control points of a cyclosporin A-sensitive mitochondrial channel involved in cell death

1996 • 420 citations

Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux

1998 • 414 citations

Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria.

1996 • 411 citations

Bcl-2 family proteins and mitochondria

1998 • 374 citations

Cyclosporin A, But Not FK 506, Protects Mitochondria and Neurons against Hypoglycemic Damage and Implicates the Mitochondrial Permeability Transition in Cell Death

1998 • 372 citations

Regulation of Ca ²⁺ release from mitochondria by the oxidation-reduction state of pyridine nucleotides

1978 • 364 citations

Cell-specific Induction of Apoptosis by Microinjection of Cytochrome c

1997 • 348 citations

Mitochondrial permeability transition in hepatocytes induced by t-BuOOH: NAD(P)H and reactive oxygen species

1997 • 336 citations

Untitled

1997 • 328 citations

The Role of Reactive Oxygen Species in Mitochondrial Permeability Transition

1997 • 317 citations

Disruption of the outer mitochondrial membrane as a result of large amplitude swelling: the impact of irreversible permeability transition

1998 • 294 citations

N-acetylcysteine (D- and L-stereoisomers) prevents apoptotic death of neuronal cells

1995 • 273 citations

Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione

1994 • 268 citations

Permeabilization of the inner mitochondrial membrane by Ca2+ ions is stimulated by t-butyl hydroperoxide and mediated by reactive oxygen species generated by mitochondria

1995 • 248 citations

The cytoskeleton of digitonin-treated rat hepatocytes.

1980 • 238 citations

Shift of the Cellular Oxidation‐Reduction Potential in Neural Cells Expressing Bcl‐2

1996 • 221 citations

The mitochondrial permeability transition in toxic, hypoxic and reperfusion injury.

1997 • 214 citations

Calcium induced release of mitochondrial cytochrome c by different mechanisms selective for brain versus liver

1999 • 190 citations

Bcl-2 and Mitochondrial Oxygen Radicals

1999 • 178 citations

Effect of Inorganic Phosphate Concentration on the Nature of Inner Mitochondrial Membrane Alterations Mediated by Ca2+ Ions

1996 • 177 citations

The Thiol-specific Antioxidant Enzyme Prevents Mitochondrial Permeability Transition

1998 • 174 citations

The thiol crosslinking agent diamide overcomes the apoptosis-inhibitory effect of Bcl-2 by enforcing mitochondrial permeability transition

1998 • 155 citations

Cytochrome c release from brain mitochondria is independent of the mitochondrial permeability transition

1998 • 144 citations

Calcium-induced activation of the mitochondrial permeability transition in hippocampal neurons

1998 • 143 citations

Phenylarsine oxide induces the cyclosporin A-sensitive membrane permeability transition in rat liver mitochondria

1991 • 114 citations

Mitochondrial membrane protein thiol reactivity with N-ethylmaleimide or mersalyl is modified by Ca2+: correlation with mitochondrial permeability transition

1997 • 95 citations

Induction of apoptosis by vanilloid compounds does not require de novo gene transcription and activator protein 1 activity.

1998 • 81 citations

Bcl-2-mediated resistance to apoptosis is associated with glutathione-induced inhibition of AP24 activation of nuclear DNA fragmentation.

1998 • 57 citations